A5022484827- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Ureteral procedures and complications
- Advanced MRI Techniques and Applications
- Immune cells in cancer
- Botulinum Toxin and Related Neurological Disorders
- Pediatric Urology and Nephrology Studies
- Conducting polymers and applications
- Obstructive Sleep Apnea Research
- RNA modifications and cancer
- Neuroscience of respiration and sleep
- Circular RNAs in diseases
- Advanced Computing and Algorithms
- MRI in cancer diagnosis
- Restless Legs Syndrome Research
- Diabetic Foot Ulcer Assessment and Management
- Neurological Complications and Syndromes
- Transplantation: Methods and Outcomes
- Medical Imaging and Pathology Studies
Soochow University
2011-2023
Second Affiliated Hospital of Soochow University
2011-2023
Group Image (Poland)
2022
Weatherford College
2022
Wuhan University
2010
Renmin Hospital of Wuhan University
2010
Abstract Long non-coding RNAs (lncRNAs) play a vital role in tumourigenesis, including that of glioma. Small nucleolar RNA host gene 1 (SNHG1) is relatively novel lncRNA involved the development multiple human tumours. However, its underlying molecular mechanism glioma has not been completely clarified. In this study, we show SNHG1 overexpressed tissues and cell lines. A series functional assays suggested promotes progression vitro vivo. Next, through online databases, luciferase reporter...
OBJECTIVE: Guanylate binding protein-1 (GBP1) is highly associated with cell proliferation, and can modulate growth invasiveness of gliomas. The relationship between GBP1 expression the prognosis glioma patients further evaluated for th
Mesenchymal stromal/stem cells (MSCs) are promising carriers in cell-based therapies against central nervous system diseases, and have been evaluated various clinical trials recent years.However, bone marrowderived MSCs (BMSCs) reportedly involved tumorigenesis initiated by glioma stem-like (GSCs).We therefore established three different orthotopic models of GSC-MSC interactions vivo using dual-color fluorescence tracing.Cell sorting micropipetting techniques were used to obtain highly...
Bromopyruvate (3-BrPA) is a glycolysis inhibitor that has been reported to have strong anti-tumour effect in many human tumours. Several studies 3-BrPA could inhibit glioma progression; however, its role on the interstitial cells microenvironment not investigated. In previous studies, we found microenvironment, stem can induce malignant transformation of macrophages and dendritic cells. this study, focused effects malignantly transformed First, inhibited proliferation dose-dependent...
Numerous studies have demonstrated that patients with Parkinson's disease (PD) a higher prevalence of substantia nigra (SN) hyperechogenicity compared controls. Our aim was to explore the neuroimaging characteristics transcranial sonography (TCS) PD and those dementia (PDD). The correlation between echogenicity SN clinical symptoms in Chinese PDD also assessed.The ratios (SN+), maximum sizes SN+, widths third ventricle (TV) were measured using TCS for all recruited patients. Data analyzed...
We investigated whether glioma stem-like cells (GSCs) malignantly transformed bone marrow mesenchymal stem (tBMSCs) in the tumor microenvironment. Transplantation of enhanced green fluorescence protein (EGFP)-labeled BMSCs into irradiated athymic nude mice was followed by intracranial injection red fluorescent protein-expressing (SU3-RFP-GSCs). Singly cloned EGFP-BMSCs, harvested from tumors showed TERT overexpression, high proliferation, colony formation and invasiveness Transwell matrigel...
Metabolism remodelling of macrophages in the glioblastoma microenvironment contributes to immunotherapeutic resistance. However, glioma stem cell (GSC)-initiated lipid metabolism transformed (tMΦs) and its effect on have not been fully elucidated. Total cholesterol (TC) levels enzyme expression GSC were evaluated found that TC tMΦs increased, enzymes calmodulin (CaM), apolipoprotein E (ApoE), liver X receptor (LXR) was upregulated. Knockdown HOXC-AS3 led a decrease proliferation, colony...
Few studies have addressed whether abnormalities in the lenticular nucleus (LN) are characteristic transcranial sonography (TCS) echo features patients with primary dystonia. This study aimed to explore alterations basal ganglia different forms of focal dystonia.cross-sectional observational was performed between December 2013 and 2014 80 dystonia 55 neurologically normal control subjects. TCS Multiple comparisons multiple rates were used compare LN hyperechogenicity ratios patient...
Using brightness mode ultrasound combined with shear wave elastography, this study aims to detect structural and functional changes of the medial head gastrocnemius (MG) in type 2 diabetes mellitus (T2DM) patients or without diabetic peripheral neuropathy (DPN).149 T2DM (DPN group non-DPN group) 60 healthy volunteers (control were enrolled. We measured absolute difference fascicle length (FL), pennation angle (PA), velocity (SWV) both MG neutral position maximal ankle joint's plantar flexion...
ObjectiveReal-time monitoring of cytokine secretion at the single immunocyte level, based on concept immune cells, sociology has been recently reported. However, relationships between gl...
Objective Real-time monitoring of cytokine secretion at the single immunocyte level, based on concept immune cells, sociology has been recently reported. However, relationships between glioma-initiating cells (GICs) and host their mutual interactions in tumor microenvironment have not directly observed remain unclear. Methods The dual fluorescence tracing technique was applied to label co-cultured GICs macrophages (Mø), two types were using a live cell imaging system. Fusion co-culture...
Objective To determine the validity of transcranial sonography (TCS) in differential diagnosis Parkinson's disease (PD) and essential tremor (ET). Methods TCS was performed 100 patients with PD, 33 ET normal controls a blind manner. The echo signal intensity substantia nigra classified into grade Ⅰ-Ⅴ for semi-quantitative analysis. When Ⅲ or more, it deemed as abnormal area hyperechogenicity would be measured its ratio to whole midbrain ( S/M ) calculated. Results 1 Semi-quantitative...
Objectives To compare and contrast the characteristics of transcranial sonography(TCS)inmultiple system atrophy(MSA)and Parkinson’s disease(PD), to assess value TCS in diagnosis differential between MSA PD. Methods TCS files were collected 29 patients 45 PD diagnosedby Departmentof Movement Disorders healthy controls.The echogenicity substantia nigra lenticular nucleus, mesencephalic area width third ventricle among three groups analyzed. Results Among groups, rate...
Objective To analyze the blood perfusion modes of retroperitoneal benign and malignant masses by real-time contrast-enhanced ultrasonography (CEUS). Methods Forty-five patients with masses, including 18 27 were performed CEUS. The contrast agent, entering style vascular patterns agent described. And diagnosis value characteristics was evaluated in masses. Results CEUS showed significant differences comparison to In center enhancement 70. 37% (19/27), periphery 72.22% (13/18) ,there...
Objective To discuss the neuroimaging characteristics of transcranial ultrasound in Parkinson′s disease (PD) patients with or without depression. Methods Transcranial sonography (TCS) was performed PD depression (PDD+ , n=50) (PDD-, n=50), (D, n=50)and healthy controls (n=50), who were enrolled Second Affiliated Hospital Soochow University from September 2010 to July 2016. The differences TCS brainstem raphe (BR) and substantia nigra (SN) four groups analyzed. According degree...
Objective To investigate the substantia nigra(SN) and brainstem raphe(BR) echogenic features of Parkinson′s disease (PD) patients with musculoskeletal pain. Methods A total 115 PD recruited in Second Affiliated Hospital Soochow University from October 2014 to May 2016 were assessed following rating scales: Unified Disease Rating Scale(UPDRS), Hoehn Yahr Staging Scale (H/Y), Hamilton for Depression (HRSD), Beck Inventory Ⅱ(BDI-Ⅱ) Visual Analogue (VAS). All subjects underwent...
Objective To explore therapeutic effects of hyperbaric oxygen(HBO) combined with nimustine(ACNU)on human glioma stem cells model, and analyze the related mechanism involved. Methods Balb/c nude mice were inoculated subcutaneously cell line SU3, then divided randomly into 4 groups, i. e., ACNU group, HBO ACNU+ group blank control group. The body weight tumor volume tumor-bearing measured regularly during experiment. Unisense microelectrode was applied to detect oxygen level in after...
Objective To analyze the values of anteroposterior diameter (APD) in fetal renal pelvis separation during different gestational weeks and predicting prognosis. Methods Totally 182 cases Second Affiliated Hospital Soochow University were enrolled this study between January 2013 October 2015. All them followed up to 12 months after birth. The detecting non-reversible hydronephrosis APD analyzed. Results Among separation, 46 detected second trimester, 136 third trimester (bilateral...
Objective To explore the molecular genetic characteristics of primary and recurrent glioblastomas (GBMs) from same patient in vivo, glioma stem cells cultured vitro, patient-derived xenograft (PDX). Methods (1) The GBM specimens one during surgical resection were collected; expressions glial fibrillary acidic protein (GFAP), nestin Ki-67 detected by immunohistochemical staining; methylation O6-methylguanine DNA methyltransferase (MGMT) gene, mutation isocitrate dehydrogenase (IDH)...
Objective To discuss the neuroimaging characteristics of transcranial ultrasound in end-stage renal disease (ESRD) with restless legs syndrome. Methods Transcranial sonography (TCS) was performed ESRD syndrome (RLS+ group, n=41), without (RLS- n=57) and control group (n=47), who were enrolled Second Affiliated Hospital Soochow University from January 2017 to December 2018. The differences TCS substantia nigra (SN), brainstem raphe (BR) red nucleus(RN) among three groups...