A5074336773- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Motor Control and Adaptation
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Vestibular and auditory disorders
- Stroke Rehabilitation and Recovery
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Hemispheric Asymmetry in Neuroscience
- Action Observation and Synchronization
- Neuroscience and Neural Engineering
- Multiple Sclerosis Research Studies
- Effects of Vibration on Health
- Cerebral Palsy and Movement Disorders
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Crime Patterns and Interventions
- Children's Physical and Motor Development
- Sport Psychology and Performance
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Atomic and Subatomic Physics Research
KU Leuven
2016-2025
Hasselt University
2016-2025
VIB-KU Leuven Center for Brain & Disease Research
2020-2025
VIB-KU Leuven Center for Cancer Biology
2018
Aging is typically associated with substantial declines in motor functioning as well robust changes the functional organization of brain networks. Previous research has investigated link between these 2 age-varying factors but examinations were predominantly limited to within motor-related Little known about relationship age-related behavioral impairments and at whole (i.e., multiple network) level. This knowledge gap surprising given that decreased segregation networks increased...
Healthy aging is accompanied by motor inhibition deficits that involve a slower process of stopping prepotent response (i.e., reactive inhibition) rather than diminished ability to anticipate proactive inhibition). Some studies suggest efficient related GABAergic function. Since age-related alterations in the GABA system have also been reported, impairments might be linked cortico-subcortical network mediates inhibition. Thirty young human adults (mean age, 23.2 years; age range, 18–34 14...
Although tDCS has been shown to improve motor learning, previous studies reported rather small effects. Since physiological effects of depend on intensity, the present study evaluated this parameter in order enhance effect skill acquisition. The different stimulation intensities anodal (atDCS) was investigated a double blind, sham controlled crossover design. In each condition, thirteen healthy subjects were instructed perform unimanual (sequence) learning task. Our results showed (1)...
The goal of this study was to optimize the transcranial magnetic stimulation (TMS) protocol for acquiring a reliable estimate corticospinal excitability (CSE) using single-pulse TMS. Moreover, minimal number stimuli required obtain CSE investigated. In addition, effect two frequently used intensities [110% relative resting motor threshold (rMT) and 120% rMT] gender evaluated. Thirty-six healthy young subjects (18 males 18 females) participated in double-blind crossover procedure. They...
Heating of gradient coils and passive shim components is a common cause instability in the B0 field, especially when intensive sequences are used. The aim study was to set benchmark for typical drift encountered during MR spectroscopy (MRS) assess need real-time field-frequency locking on MRI scanners by comparing field data from large number sites. A standardized protocol developed 80 participating sites using 99 3T 3 major vendors. Phantom water signals were acquired before after an EPI...
Perceptual processes play an important role in motor learning. While it is evident that visual information greatly contributes to learning new movements, much less known about provision of prescriptive proprioceptive information. Here, we investigated whether passive (proprioceptively-based) movement training was comparable active for a bimanual task. Three groups practiced coordination pattern with 1∶2 frequency ratio and 90° phase offset between both wrists Lissajous feedback over the...
Abstract The long‐term effect of daily somatosensory stimulation with transcutaneous electrical nerve (TENS) on reorganization the motor cortex was investigated in a group neurologically intact humans. scalp representation corticospinal projection to finger (APB, ADM) and forearm (FCR, ECR) muscles mapped by means transcranial magnetic (TMS) before after 3‐week intervention period, using map area volume, topographical overlaps between cortical representations these as primary dependent...
Levels of GABA, the main inhibitory neurotransmitter in brain, can be regionally quantified using magnetic resonance spectroscopy (MRS). Although GABA is crucial for efficient neuronal functioning, little known about age-related differences levels and their relationship with changes brain structure. Here, we investigated effect age on within left sensorimotor cortex occipital a sample 85 young older adults MEGA-PRESS sequence. Because distribution varies across different tissues, various...
Establishing the associations between magnetic resonance spectroscopy (MRS)-assessed gamma-aminobutyric acid (GABA) levels and transcranial stimulation (TMS)-derived 'task-related' modulations in GABAA receptor-mediated inhibition how these change with advancing age is a topic of interest field human neuroscience. In this study, we identified relationship GABA task-related dominant (left) non-dominant (right) sensorimotor (SM) cortices. were measured using edited MRS was short-interval...
Over the last decade, there has been an increasing number of studies combining transcranial magnetic stimulation (TMS) and resonance spectroscopy (MRS). MRS provides a manner to non-invasively investigate molecular concentrations in living brain thus identify metabolites involved physiological pathological processes. Particularly MRS-detectable glutamate, major excitatory neurotransmitter, gamma-aminobutyric acid (GABA), inhibitory are interest when TMS MRS. is non-invasive technique that...
Background. Transcutaneous electrical nerve stimulation (TENS) is commonly used in neurorehabilitation for the treatment of pain and spasticity. Objective. The long-term effects sensory by means TENS on hand sensitivity were investigated patients with multiple sclerosis (MS). Methods. was applied 3 weeks (1 hour per day) median region dominant hand. Sensitivity assessed Semmes—Weinstein monofilaments before 12 hours following last intervention as well later. Results. Long-lasting increases...
Purpose: To assess the effects of atDCS on motor performance in patients with multiple sclerosis (MS).Previously, anodal transcranial direct current stimulation (atDCS) has been shown to improve healthy subjects and neurodegenerative populations.However, effect is not examined MS.Methods: In study, a sham controlled double-blind crossover design was used evaluate 20 minutes 1 mA or tDCS (stDCS) unimanual sequence-training task, consisting sequential finger presses computer keyboard most...
Background The hardware and software differences between MR vendors individual sites influence the quantification of spectroscopy data. An analysis a large data set may help to better understand sources total variance in quantified metabolite levels. Purpose To compare multisite quantitative brain acquired healthy participants at 26 by using vendor-supplied single-voxel point-resolved (PRESS) sequence. Materials Methods protocol acquire short-echo-time PRESS from midparietal region was...
We investigated the effect of age on ability to modulate GABAA-ergic and GABAB-ergic inhibitory activity during stopping action (reactive inhibition) preparation stop (proactive inhibition). Twenty-five young twenty-nine older adults performed an anticipated response version stop-signal task with varying levels probability. Paired-pulse transcranial magnetic stimulation was applied left primary motor cortex assess modulation GABAA-mediated short-interval intracortical inhibition (SICI)...