A5056721453- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Mast cells and histamine
- Advanced Neuroimaging Techniques and Applications
- Circadian rhythm and melatonin
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Neuroendocrine regulation and behavior
- Motor Control and Adaptation
- Advanced MRI Techniques and Applications
- Receptor Mechanisms and Signaling
- Eating Disorders and Behaviors
- Balance, Gait, and Falls Prevention
- Substance Abuse Treatment and Outcomes
- Behavioral Health and Interventions
- Neural dynamics and brain function
- Allergic Rhinitis and Sensitization
- Obsessive-Compulsive Spectrum Disorders
- Schizophrenia research and treatment
Maastricht University
2009-2023
KU Leuven
2015-2023
King's College London
2013-2018
Wellcome Centre for Human Neuroimaging
2013-2017
Aging is typically associated with substantial declines in motor functioning as well robust changes the functional organization of brain networks. Previous research has investigated link between these 2 age-varying factors but examinations were predominantly limited to within motor-related Little known about relationship age-related behavioral impairments and at whole (i.e., multiple network) level. This knowledge gap surprising given that decreased segregation networks increased...
Instrumental learning, i.e., learning that specific behaviors lead to desired outcomes, occurs through goal-directed and habit memory systems. Exposure acute stress has been shown result in less control, thus rendering behavior more habitual. The aim of the current studies was replicate extend findings on stress-induced prompting habitual responding specifically focused role cortisol reactivity. Study 1 used an established outcome devaluation paradigm assess control. 2 utilized a modified...
Automatic tendencies toward physical activity and sedentary stimuli are involved in the regulation of behavior. However, brain regions underlying these automatic remain largely unknown. Here, we used an approach-avoidance task magnetic resonance imaging (MRI) 42 healthy young adults to investigate whether cortical subcortical underpinning reward processing executive function associated with tendencies. At behavioral level, results showed more errors avoidance behavior following than stimuli....
Skill acquisition capabilities vary substantially from one individual to another. Volumetric brain studies have demonstrated that global volume of several subcortical structures predicts variations in learning outcome young adults (YA) and older (OA). In this study, for the first time, we utilized shape analysis, which offers a more sensitive detection subregional anatomical deformations, investigate whether anatomy is associated with training-induced performance improvement on bimanual task...
Abstract There is a convergence in the literature toward critical role for basal ganglia action selection. However, which substructures within fulfill this still unclear. Here we used shape analyses of structural magnetic resonance imaging data to determine extent structures predict performance easy and complex multilimb reaction‐time tasks young old adults. Results revealed that inward deformation (i.e., local atrophy) nucleus accumbens caudate were predictive longer selection times...
Abstract. Instrumental learning is regulated by two memory systems: a relatively rigid but efficient habit system and flexible resource-demanding goal-directed system. Previous work has demonstrated that exposure to acute stress may shift the balance between these systems toward habitual In current study, we used 2-day outcome devaluation paradigm with 75% reward contingency rate altered food categories replicate extend our previous findings. Participants learned neutral...
Abstract The Compensation Related Utilization of Neural Circuits Hypothesis (CRUNCH) proposes a framework for understanding task-related brain activity changes as function healthy aging and task complexity. Specifically, it affords the following predictions: (i) all adult age groups display more activation with increases in complexity, (ii) older adults show compared younger at low complexity levels, (iii) disproportionately increase increased but (iv) smaller (or no) highest levels. To test...
Results from recent animal studies suggest an important role for histamine in memory functioning. Histaminergic drugs might prove beneficial people suffering impairment. To determine if is involved functioning this study evaluates the effects of histaminergic dysfunction on performance by administrating a H 1 -antagonist to humans. The was conducted according 4-way, double-blind, crossover design 20 healthy female volunteers, aged 18—45 years. On each test day subjects completed three...
Acute stress is associated with a shift from goal-directed to habitual behavior. This stress-induced preference for behavior has been suggested as potential mechanism by which binge eating disorder (BED) patients succumb large amounts of high-caloric foods in an uncontrolled manner (i.e., episodes). While healthy subjects the balance between and subserved anterior cingulate cortex (ACC), insular cortex, orbitofrontal (OFC), caudate nucleus, posterior putamen, brain that underlies this...
BACKGROUND AND PURPOSE The histaminergic neurotransmitter system is currently under investigation as a target for drug treatment of cognitive deficits in clinical disorders. therapeutic potential new drugs may initially be screened using model dysfunction, example, associated with the use centrally active antihistamines. Of selective second generation antihistamines, cetirizine has been found to have central nervous effects. aim present study was determine whether can used tool hypofunction....
Schizophrenia is a highly debilitating disorder characterized by hallucinations and delusions, but also impaired cognition such as memory. While delusions are the main target for pharmacological treatment, cognitive impairments rarely treated. Evidence exists that histamine has role in deficits schizophrenia, which could be basis of development histamine-type treatment. Histamine H₃ antagonists have been shown to improve memory performance experimental animals, these effects little...
Background and purpose: Animal studies show that histamine plays a role in cognitive functioning H 3 ‐receptor antagonists, which increase histaminergic function through presynaptic receptors, improve performance models of clinical deficits. In order to test such new drugs humans, model for impairments induced by low functions would be useful. Studies with 1 antagonists have shown limitations as model. Here we evaluated whether depletion L‐histidine, the precursor histamine, was effective...
Abstract: Successfully switching between tasks is critical in many daily activities. Age‐related slowing of this behavior has been documented extensively, but the underlying neural mechanisms remain unclear. Here, we investigated contribution brain white matter changes associated with myelin alterations to age‐related performance. Diffusion tensor imaging derived radial diffusivity (RD) and magnetization transfer ratio (MTR) were selected as sensitive measures. These metrics studied relation...