A5057324811- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Autism Spectrum Disorder Research
- Fetal and Pediatric Neurological Disorders
- Blind Source Separation Techniques
- Neonatal and fetal brain pathology
- Mental Health Research Topics
- Psychedelics and Drug Studies
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Children's Physical and Motor Development
- Traumatic Brain Injury Research
- Heart Rate Variability and Autonomic Control
- Optical Imaging and Spectroscopy Techniques
- Tactile and Sensory Interactions
- Transcranial Magnetic Stimulation Studies
- Fault Detection and Control Systems
- Neural and Behavioral Psychology Studies
- Multiple Sclerosis Research Studies
- Congenital heart defects research
- Health, Environment, Cognitive Aging
Kennedy Krieger Institute
2016-2025
Johns Hopkins Medicine
2015-2025
Johns Hopkins University
2016-2025
University of North Carolina at Chapel Hill
2009-2010
Duke University
2009
Indiana University
2009
Indiana University School of Medicine
2009
Washington University in St. Louis
2004
Grand Valley State University
2003
The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance scope brain connectomics research in Spectrum Disorder (ASD). Consistent with initial ABIDE effort I), that released 1112 datasets 2012, this new multisite open-data resource is an aggregate resting state functional magnetic resonance imaging (MRI) and corresponding structural MRI phenotypic datasets. II includes from additional 487 individuals ASD 557 controls previously collected across 16...
Abstract Spatial normalization of brains to a standardized space is widely used approach for group studies in functional magnetic resonance imaging (fMRI) data. Commonly template‐based approaches are complicated by signal dropout and distortions echo planar (EPI) The most software packages implement two common strategies: (1) affine transformation the EPI data an template followed nonlinear registration (EPInorm) (2) anatomic image given subject, template, which produces that applied...
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have recaptured the imagination of both science popular culture, may efficacy in treating a wide range psychiatric disorders. Human animal studies drug action brain demonstrated involvement serotonin 2A (5-HT2A) receptor cerebral cortex acute action, but different models evolved to try explain impact 5-HT2A activation on neural systems. Two prominent (the cortico-striatal thalamo-cortical, or CSTC, model...
Accumulating evidence suggests that motor impairments are prevalent in autism spectrum disorder (ASD), relate to the social and communicative deficits at core of diagnosis may reflect abnormal connectivity within brain networks underlying control learning. Parcellation resting‐state functional data using spectral clustering approaches has been shown be an effective means visualizing organization but most commonly applied explorations normal function. This article presents a parcellation key...
Autism spectrum disorders ( ASD ) are associated with differences in sensory sensitivity and affective response to stimuli, the neural basis of which is still largely unknown. We used psychophysics functional magnetic resonance imaging fMRI investigate responses somatosensory stimulation three textured surfaces that spanned a range roughness pleasantness sample adults control group. While psychophysical ratings were similar across two groups, group gave pleasant unpleasant textures more...
Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry other lateralized cognitive and behavioural domains. Motor deficits are among the earliest most prominent symptoms ASC precede core social communicative symptoms. Here, we investigate whether motor circuit connectivity is (1) atypically children (2) this relates to autistic...
Successful automated diagnoses of attention deficit hyperactive disorder (ADHD) using imaging and functional biomarkers would have fundamental consequences on the public health impact disease. In this work, we show results predictability ADHD discuss scientific diagnostic impacts research. We created a prediction model landmark 200 data set focusing resting state connectivity (rs-fc) structural brain imaging. predicted status subtype, obtained by behavioral examination, data, intelligence...
Abstract Executive functions (EFs) are used to set goals, plan for the future, inhibit maladaptive responses, and change behavior flexibly. Although some studies point specific EF profiles in autism spectrum disorder (ASD) attention-deficit/hyperactivity (ADHD) — prevalent often highly comorbid neurodevelopmental disorders others have not differentiated them. The objective of current study was identify distinct across typically developing (TD) children with ASD ADHD. We employed a latent...
Multiband acquisition, also called simultaneous multislice, has become a popular technique in resting-state functional connectivity studies. (MB) acceleration leads to higher temporal resolution but spatially heterogeneous noise amplification, suggesting the costs may be greater areas such as subcortex. We evaluate MB factors of 2, 3, 4, 6, 8, 9, and 12 with 2 mm isotropic voxels, additionally 3.3 single-band acquisitions, on 32-channel head coil. Noise amplification was deeper brain...
Abstract Background Autism spectrum disorder (ASD) is highly heritable and phenotypically variable. Neuroimaging markers reflecting variation in behavior will provide insights into circuitry subserving core features. We examined functional correlates of ASD symptomology at school-age, while accounting for associated behavioral cognitive domains, a longitudinal sample followed from infancy enriched those with genetic liability ASD. Methods Resting state connectivity MRIs (fcMRI) data were...
Motor impairments are prevalent in children with autism spectrum disorders (ASD) and perhaps the earliest symptoms to develop. In addition, motor skills relate communicative/social deficits at core of ASD diagnosis, these behavioral may reflect abnormal connectivity within brain networks underlying control learning. Despite fact that abnormalities well-characterized, there remains a fundamental disconnect between complexity clinical presentation neurobiological mechanisms. this study, we...
Intra-subject variability (ISV) is the most consistent behavioral deficit in Attention Deficit Hyperactivity Disorder (ADHD). ISV may be associated with networks involved sustaining task control (cingulo-opercular network: CON) and self-reflective lapses of attention (default mode DMN). The current study examined whether connectivity supporting attentional atypical children ADHD. Group differences full-brain connection strength brain–behavior associations measures were for late-developing...
The exclusion of high-motion participants can reduce the impact motion in functional Magnetic Resonance Imaging (fMRI) data. However, may change distribution clinically relevant variables study sample, and resulting sample not be representative population. Our goals are two-fold: 1) to document biases introduced by common practices connectivity research 2) introduce a framework address these treating excluded scans as missing data problem. We use autism spectrum disorder children without an...
Artifacts in functional MRI (fMRI) data cause deviations from common distributional assumptions, introduce spatial and temporal outliers, reduce the signal-to-noise ratio of -- all which can have negative consequences for downstream statistical analysis. Scrubbing is a technique excluding fMRI volumes thought to be contaminated by artifacts generally comes two flavors. Motion scrubbing based on subject head motion-derived measures popular but suffers number drawbacks, especially high rates...
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, emotional development beginning prenatally planned through early childhood. acquisition of multimodal magnetic resonance-based brain data is central to the study's core protocol. However, application Magnetic Resonance Imaging (MRI) methods in this population complicated by technical challenges difficulties imaging life. Overcoming...
Attention-deficit/hyperactivity disorder (ADHD) is associated with atypical fronto-subcortical neural circuitry and heightened delay discounting, or a stronger preference for smaller, immediate rewards over larger, delayed rewards. Recent evidence of ADHD-related sex differences in brain structure function suggests anomalies may differ among girls boys ADHD. The current study examined whether the functional connectivity (FC) within differs ADHD compared to same-sex typically developing (TD)...