A5009733613- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- Schizophrenia research and treatment
- Cardiovascular Function and Risk Factors
- Traumatic Brain Injury Research
- Maternal Mental Health During Pregnancy and Postpartum
- Heart Rate Variability and Autonomic Control
- Electrolyte and hormonal disorders
- Stress Responses and Cortisol
- Autism Spectrum Disorder Research
- Heart Failure Treatment and Management
- Pregnancy and Medication Impact
- Cardiac Imaging and Diagnostics
- Child and Adolescent Psychosocial and Emotional Development
- Neurological disorders and treatments
- Children's Physical and Motor Development
- Decision-Making and Behavioral Economics
- Advanced Memory and Neural Computing
- Cardiac Arrhythmias and Treatments
Feinstein Institute for Medical Research
2016-2025
Hofstra University
2018-2025
Zucker Hillside Hospital
2018-2025
Northwell Health
2018-2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2018-2024
Roche (Switzerland)
2023
Novartis (Switzerland)
2023
Sunovion (United Kingdom)
2023
Otsuka (United States)
2023
Hillside Rehabilitation Hospital
2023
Accumulating evidence suggests that motor impairments are prevalent in autism spectrum disorder (ASD), relate to the social and communicative deficits at core of diagnosis may reflect abnormal connectivity within brain networks underlying control learning. Parcellation resting‐state functional data using spectral clustering approaches has been shown be an effective means visualizing organization but most commonly applied explorations normal function. This article presents a parcellation key...
Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry other lateralized cognitive and behavioural domains. Motor deficits are among the earliest most prominent symptoms ASC precede core social communicative symptoms. Here, we investigate whether motor circuit connectivity is (1) atypically children (2) this relates to autistic...
Successful automated diagnoses of attention deficit hyperactive disorder (ADHD) using imaging and functional biomarkers would have fundamental consequences on the public health impact disease. In this work, we show results predictability ADHD discuss scientific diagnostic impacts research. We created a prediction model landmark 200 data set focusing resting state connectivity (rs-fc) structural brain imaging. predicted status subtype, obtained by behavioral examination, data, intelligence...
A dissociable set of regions was active for the executive processing associated with overcoming a prepotent response tendency and task switching. Regions prepotency were primarily frontal may be part system involved in top-down biasing conflict reduction. Posterior recruited switching between tasks likely play role reconfiguring stimulus-response mappings. Precuneus activity common to both manipulations reflect increased visual attention due more difficult demands.
Motor impairments are prevalent in children with autism spectrum disorders (ASD) and perhaps the earliest symptoms to develop. In addition, motor skills relate communicative/social deficits at core of ASD diagnosis, these behavioral may reflect abnormal connectivity within brain networks underlying control learning. Despite fact that abnormalities well-characterized, there remains a fundamental disconnect between complexity clinical presentation neurobiological mechanisms. this study, we...
Intra-subject variability (ISV) is the most consistent behavioral deficit in Attention Deficit Hyperactivity Disorder (ADHD). ISV may be associated with networks involved sustaining task control (cingulo-opercular network: CON) and self-reflective lapses of attention (default mode DMN). The current study examined whether connectivity supporting attentional atypical children ADHD. Group differences full-brain connection strength brain–behavior associations measures were for late-developing...
Identification of robust biomarkers that predict individualized response to antipsychotic treatment at the early stage psychotic disorders remains a challenge in precision psychiatry. The aim this study was investigate whether any functional connectome-based neural traits could serve as such biomarker.
Motor control relies on well-established motor circuits, which are critical for typical child development. Although many imaging studies have examined task activation during performance, none the relationship between functional intrinsic connectivity and ability. The current study investigated resting state within network performance assessment outside of scanner in 40 typically developing right-handed children. Better correlated with greater left-lateralized (mean left hemisphere—mean right...
Motor impairments are prevalent in children with autism spectrum disorder. The Serial Reaction Time Task, a well-established visuomotor sequence learning probe, has produced inconsistent behavioral findings individuals autism. Moreover, it remains unclear how underlying neural processes for compare to typically developing children. Neural activity differences were assessed using functional magnetic resonance imaging during modified version of the Task and without Though there was no group...
Abstract Recent efforts to evaluate the heritability of brain’s functional connectome have predominantly focused on static connectivity. However, evaluating connectivity changes across time can provide valuable insight about inherent dynamic nature brain function. Here, Human Connectome Project resting-state fMRI data was examined determine whether there is a genetic basis for fluctuations in The variance, addition mean and standard connectivity, evaluated. Heritability estimated using...
Inhibitory control commonly recruits a number of frontal regions: pre-supplementary motor area (pre-SMA), eye fields (FEFs), and right-lateralized posterior inferior gyrus (IFG), dorsal anterior insula (DAI), dorsolateral prefrontal cortex (DLPFC), junction (IFJ). These regions may directly implement inhibitory or be more generally involved in executive functions. Two go/no-go tasks were used to distinguish specifically recruited for inhibition from those that additionally show increased...
Parasympathetic arousal is associated with states of heightened attention and well-being. Arousal may affect widespread cortical subcortical systems across the brain, however, little known about its influence on cognitive task processing performance. In current study, healthy adult participants (n = 20) underwent multi-band echo-planar imaging (TR 0.72 s) simultaneous pulse oximetry recordings during performance Multi Source Interference Task (MSIT), Oddball (OBT), rest. Processing speed...
Recent research has implicated altered neural response to interpersonal feedback as an important factor in adolescent depression, with existing studies focusing on responses from virtual peers. We investigated whether depressed adolescents differed healthy youth social evaluative mothers. During neuroimaging, twenty a current episode of major depressive disorder (MDD) and 28 controls listened previously recorded audio clips their own mothers' praise, criticism neutral comments. Whole-brain...
Abstract Background The cerebellum has traditionally been associated with motor functions, but recent evidence highlights its critical role in cognitive and emotional regulation, contributing to the neuropathology of schizophrenia. Our previous data-driven research demonstrated that cerebellar-cortical functional connectivity can predict antipsychotic treatment outcomes first-episode psychosis (FEP). present study aimed investigate specific cerebellar systems involved prediction. Study...
This study examined functional connectivity of the default mode network (DMN) and brain-behavior relationships in a pilot cohort children with chronic mild to moderate traumatic brain injury (TBI).Compared uninjured peers, TBI demonstrated less anti-correlated between DMN right Brodmann Area 40 (BA 40). In TBI, more anomalous anti-correlated) BA was linked poorer performance on response inhibition tasks.Collectively, these preliminary findings suggest that may relate longterm outcomes pediatric TBI.