A5036181204- Traumatic Brain Injury Research
- Autoimmune Neurological Disorders and Treatments
- Infectious Encephalopathies and Encephalitis
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- Child Abuse and Related Trauma
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Neurological Complications and Syndromes
- Aortic Disease and Treatment Approaches
- Intensive Care Unit Cognitive Disorders
- Autoimmune and Inflammatory Disorders Research
- Congenital heart defects research
- Ubiquitin and proteasome pathways
- Herpesvirus Infections and Treatments
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Epilepsy research and treatment
- Cervical and Thoracic Myelopathy
- Autism Spectrum Disorder Research
- Neonatal and fetal brain pathology
- Genomic variations and chromosomal abnormalities
- Child Abuse and Trauma
- Restraint-Related Deaths
Baylor College of Medicine
2017-2025
Texas Children's Hospital
2017-2025
Child Neurology Associates
2019
Institute of Developmental Physiology
2018
Kennedy Krieger Institute
2011-2017
Johns Hopkins University
2012-2017
Johns Hopkins Medicine
2013-2015
University of Baltimore
2014
The SYNGAP1 gene encodes for a small GTPase-regulating protein critical to dendritic spine maturation and synaptic plasticity. Mutations have recently been identified cause breadth of neurodevelopmental disorders including autism, intellectual disability, epilepsy. purpose this work is define the phenotypic spectrum mutations identify potential biomarkers clinical severity developmental progression. A retrospective data analysis individuals with was conducted. Data included genetic...
Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are generally asymptomatic or have mild symptoms low rates of hospitalization (<2%) and death (<0.03%).1 After initial infection, some children, including those who experienced disease, develop other postacute manifestations COVID, multisystem inflammatory in children (MIS-C, not discussed this statement) sequelae SARS-CoV-2 infection. The latter post-COVID condition may be known as long long-haul COVID-19,...
Prior studies have revealed remarkable phenotypic heterogeneity in KCNQ2-related disorders, correlated with effects on biophysical features of heterologously expressed channels. Here, we assessed phenotypes and functional properties associated KCNQ2 missense variants R144W, R144Q, R144G. We also explored vitro blockade channels carrying R144Q mutant subunits by amitriptyline.Patients were identified using the RIKEE database through clinical collaborators. Phenotypes collected a standardized...
OBJECTIVES Survivors of the PICU face long-term morbidities across health domains. In this study, we detail active follow-up programs (PFUPs) and identify perceptions barriers about development maintenance PFUPs. METHODS A web link to an adaptive survey was distributed through organizational listservs. Descriptive statistics characterized sample details existing Likert responses regarding benefits were summarized. RESULTS One hundred eleven respondents represented 60 institutions located in...
This study examined functional connectivity of the default mode network (DMN) and brain-behavior relationships in a pilot cohort children with chronic mild to moderate traumatic brain injury (TBI).Compared uninjured peers, TBI demonstrated less anti-correlated between DMN right Brodmann Area 40 (BA 40). In TBI, more anomalous anti-correlated) BA was linked poorer performance on response inhibition tasks.Collectively, these preliminary findings suggest that may relate longterm outcomes pediatric TBI.
Background and objective Disparities in outcomes for pediatric patients with traumatic brain injuries (TBI) rural populations racial ethnic minority groups have been documented. In light of this, we examined physician champions' perceptions healthcare equity hospitalized children TBI. Methods We surveyed 10 TBI champions at US trauma centers (PTCs) regarding organizational characteristics, barriers, facilitators (domains specific) terms improving equity, priorities to redress inequities....
Current concussion evidence is derived largely from teenagers and adults. Concussion in younger children occurs within the context of neuromaturation, with differing age-based pathophysiological responses to injury. Therefore, our current understanding older adults unlikely directly apply children.To describe patient variables, clinical course, factors associated time discharge care 6-12 years age treated an interdisciplinary rehabilitation-based clinic.Retrospective chart...
PURPOSE: Functionally relevant alterations in resting state fMRI (rs-fMRI) connectivity have been identified adults with traumatic brain injury (TBI). We evaluated rs-fMRI children TBI and explored the relationship between altered measures of neurological f unction. METHODS: Rs-fMRI was obtained 14 after controls matched for age, sex, handedness. Whole-brain separately default mode network (DMN) dorsal attention (DAN); Between-group contrasts regions control cohorts. In TBI, relationships...
Cerebellar agenesis (CA) may result from both a genetically mediated as well disruptive etiology. In preterm neonates, the cerebellum is highly susceptible to injury. Different neuroimaging findings have been reported in disrupted cerebellar dev
NA
<h3>BACKGROUND AND PURPOSE:</h3> Abusive head trauma is the leading cause of morbidity and mortality in young children. Radiology provides valuable information for this challenging diagnosis, but no single neuroimaging finding independently diagnostic abusive trauma. Our purposes were to describe prevalence brain spine findings analyze association with clinical factors determine which may be used as prognostic indicators. <h3>MATERIALS METHODS:</h3> Children a confirmed diagnosis between...
<h3>Objective:</h3> To describe two rare cases of MOG-Ab Disease presenting with status epilepticus in pediatric patients. <h3>Background:</h3> Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease is associated conditions such as optic neuritis and acute disseminated encephalomyelitis. A newer entity fluid-attenuated inversion recovery (FLAIR) imaging hyperintense cortical lesions MOG encephalitis seizures (FLAMES) has also been described. These patients typically present...
OBJECTIVES: To characterize variation in treatments and outcomes of pediatric patients admitted to children’s hospitals with acute disseminated encephalomyelitis (ADEM). METHODS: In this retrospective cohort study, we used data from the Pediatric Health Information System. Children &gt;30 days old who were hospitalized 2010 2015 ADEM included. Variables analyzed admission an ICU. Primary discharge disposition readmissions for relapses (ADEM readmissions) or continued comorbidities...