A5026298510- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Neural and Behavioral Psychology Studies
- Photoreceptor and optogenetics research
- Cannabis and Cannabinoid Research
- Nicotinic Acetylcholine Receptors Study
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
- Psychedelics and Drug Studies
- Hormonal and reproductive studies
- Glioma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Estrogen and related hormone effects
- Genetics and Neurodevelopmental Disorders
- Radiopharmaceutical Chemistry and Applications
- Stress Responses and Cortisol
- Chemical synthesis and alkaloids
- Pain Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
University of Maryland, Baltimore
2016-2025
Johns Hopkins Medicine
2021
Johns Hopkins University
2021
National Institute on Alcohol Abuse and Alcoholism
2011-2013
National Institutes of Health
2011-2013
Vanderbilt University Medical Center
2007-2008
Lexicon Pharmaceuticals (United States)
2001
The University of Texas MD Anderson Cancer Center
2000
UConn Health
1982
Hartford Financial Services (United States)
1982
Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, its release dynamics have traditionally been linked to changes midbrain dopamine neuron activity. Here, we report that selective endogenous cholinergic activation achieved via vitro optogenetic stimulation of nucleus accumbens, terminal field dopaminergic neurons, elicits real-time release. This mechanism occurs direct actions on terminals, does not require firing within the midbrain, is dependent...
A high-throughput, retrovirus-mediated mutagenesis method based on gene trapping in embryonic stem cells was used to identify a novel mouse gene. The human ortholog encodes transmembrane protein containing five extracellular immunoglobulin-like domains that is structurally related NEPHRIN, associated with congenital nephrotic syndrome. Northern analysis revealed wide expression humans and mice, highest kidney. Based similarity NEPHRIN abundant kidney, this designated NEPH1 the retroviral...
Cognitive abilities, such as volitional attention, operate under top-down, executive frontal cortical control of hierarchically lower structures. The circuit mechanisms underlying this process are unresolved. claustrum possesses interconnectivity with many areas and, thus, is hypothesized to orchestrate the mantle for top-down control. Whether receives input and how may be processed by have yet formally tested, however. We reveal that a rich anterior cingulate cortex (ACC) encodes...
Psychedelic drugs, including the serotonin 2a (5-HT
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have recaptured the imagination of both science popular culture, may efficacy in treating a wide range psychiatric disorders. Human animal studies drug action brain demonstrated involvement serotonin 2A (5-HT2A) receptor cerebral cortex acute action, but different models evolved to try explain impact 5-HT2A activation on neural systems. Two prominent (the cortico-striatal thalamo-cortical, or CSTC, model...
The claustrum is a prominent but ill-defined forebrain structure that has been suggested to integrate multisensory information and perhaps transform percepts into consciousness. claustrum's shape vague borders have hampered experimental assessment of its functions. We used matrix-assisted laser desorption ionization–imaging mass spectrometry reveal novel protein marker, G-protein gamma2 subunit (Gng2), which enriched in the not adjacent structures rat forebrain. spatial pattern Gng2...
The striatum has important roles in motor control and action learning and, like many brain regions, receives multiple monoaminergic inputs. We have examined serotonergic modulation of rat mouse corticostriatal neurotransmission find that serotonin (5-HT) activates 5-HT 1b receptors resulting a long-term depression (LTD) glutamate release striatal output we termed 5-HT–LTD. 5-HT–LTD is presynaptically mediated, cAMP pathway dependent, inducible by endogenous 5-HT, as revealed application...
J. Neurochem. (2011) 119 , 303–313. Abstract The neurological effects of organophosphate (OP) pesticides, commonly used on foods and in households, are an important public health concern. Furthermore, subclinical exposure to combinations organophosphates is implicated Gulf War illness. Here, we characterized the broadly insecticide chlorpyrifos (CPF) dopamine glutamatergic neurotransmission effectors corticostriatal motor/reward circuitry. CPF potentiated protein kinase A (PKA)‐dependent...
The claustrum is a telencephalic gray matter structure with various proposed functions, including sensory integration and attentional allocation. Underlying these concepts the reciprocal connectivity of most, if not all, areas cortex. What remains to be elucidated inform functional hypotheses further whether pattern exists in strength between given cortical area claustrum. To this end, we performed series retrograde neuronal tract tracer injections into rat along processing hierarchy, from...
The nigrostriatal dopaminergic system is implicated in action control and learning. A large body of work has focused on the contribution this to modulation corticostriatal synapse, predominant synapse type striatum. Signaling through D2 dopamine receptor necessary for endocannabinoid-mediated depression glutamate release. Here we review known details mechanism discuss newly discovered signaling pathways interacting with that ultimately exert dynamic cortical input striatum striatal output....
The claustrum is a narrow subcortical brain structure that resides between the striatum and insular cortex. function of not fully described, while our previous work supports role for in top-down cognitive control action, other evidence suggests may be involved detecting salient changes external environment. anterior cingulate cortex (ACC) (aINS) are two major participants salience network human regions activate response to stimuli. While bidirectional connections ACC exist from mouse...
The claustrum is a telencephalic gray matter nucleus that richly interconnected with the neocortex. This structure subserves top-down executive functions require frontal cortical control of posterior regions. However, functional anatomical support for allowing long-range intercortical communication lacking. To test this, we performed channelrhodopsin-assisted long-circuit mapping strategy in mouse brain slices. We find anterior cingulate cortex input to transiently amplified by neurons that,...
Glutamatergic projections of the thalamic rostral intralaminar nuclei thalamus (rILN) innervate dorsal striatum (DS) and are implicated in dopamine (DA)-dependent incubation drug seeking. However, mechanism by which rILN signaling modulates reward seeking striatal DA release is unknown. We find that activation inputs to DS drives cholinergic interneuron burst-firing behavior D2 receptor-dependent post-burst pauses firing. In vivo, optogenetic this pathway reinforcement a D1 manner,...