A5090278385- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- CRISPR and Genetic Engineering
- Memory and Neural Mechanisms
- Neuroscience, Education and Cognitive Function
- Photoreceptor and optogenetics research
- HIV Research and Treatment
- Visual perception and processing mechanisms
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Nicotinic Acetylcholine Receptors Study
National Eye Institute
2024
University of Maryland, Baltimore
2017-2023
Institute of Neurobiology
2023
Massachusetts General Hospital
2014-2016
There is growing evidence that estradiol (E2) enhances fear extinction memory consolidation. However, it unclear how E2 influences the nodes of network to enhance memory. This study begins delineate neural circuits underlying influence on acquisition and consolidation in female rats. After conditioning (day 1), naturally cycling rats underwent learning 2) a low‐E2 state, receiving systemic administration either or vehicle prior training. Extinction recall was then tested 24 hr later 3). We...
Glutamatergic projections of the thalamic rostral intralaminar nuclei thalamus (rILN) innervate dorsal striatum (DS) and are implicated in dopamine (DA)-dependent incubation drug seeking. However, mechanism by which rILN signaling modulates reward seeking striatal DA release is unknown. We find that activation inputs to DS drives cholinergic interneuron burst-firing behavior D2 receptor-dependent post-burst pauses firing. In vivo, optogenetic this pathway reinforcement a D1 manner,...
The basal ganglia play a key role in visual perceptual decisions. Despite being the primary target for inputs from cortex, posterior striatum′s (PS) involvement behavior remains unknown rodents. We reveal that PS direct pathway is largely segregated dorsomedial striatum (DMS) pathway, other major striatal cortex. investigated of decisions by optogenetically stimulating medium spiny neurons (D1-MSNs) mice performing change-detection task. D1-MSN activation robustly biased manner dependent on...
Extinction of conditioned fear has been extensively studied in male rodents. Recently, there have an increasing number studies indicating that neural mechanisms for certain behavioral tasks and response behaviors are different females males. Using research can represent a challenge because the variation gonadal hormones during their estrous cycle. This protocol describes well-established procedures useful investigating role estrogen extinction memory consolidation female rats. Phase cycle...
Substance use disorder is a chronic disease and leading cause of disability around the world. The NAc major brain hub mediating reward behavior. Studies demonstrate exposure to cocaine associated with molecular functional imbalance in medium spiny neuron subtypes (MSNs), dopamine receptor 1 2 enriched D1-MSNs D2-MSNs. We previously reported repeated induced transcription factor early growth response 3 ( Egr3 ) mRNA D1-MSNs, reduced it Here, we report our findings male mice inducing MSN...
The dorsal striatum (DS) mediates the selection of actions for reward acquisition necessary survival. Striatal pathology contributes to several neuropsychiatric conditions, including aberrant specific rewards in addiction. A major source glutamate driving striatal activity is rostral intralaminar nuclei (rILN) thalamus. Yet, information that relayed support action unknown. Here, we discovered rILN neurons projecting DS are innervated by a range cortical and subcortical afferents rILN→DS...
Extinction of conditioned fear has been extensively studied in male rodents. Recently, there have an increasing number studies indicating that neural mechanisms for certain behavioral tasks and response behaviors are different females males. Using research can represent a challenge because the variation gonadal hormones during their estrous cycle. This protocol describes well-established procedures useful investigating role estrogen extinction memory consolidation female rats. Phase cycle...
Abstract Substance use disorder is a debilitating chronic disease and leading cause of disability around the world. The nucleus accumbens (NAc) major brain hub that mediates reward behavior. Studies demonstrate exposure to cocaine associated with molecular functional imbalance in two NAc medium spiny neuron subtypes (MSNs), dopamine receptor 1 2 enriched D1-MSNs D2-MSNs. Our previous reports showed repeated induced transcription factor early growth response 3 (Egr3) mRNA D1-MSNs, while...
Abstract The dorsal striatum (DS) mediates the selection of actions for reward acquisition necessary survival. Striatal pathology contributes to several neuropsychiatric conditions, including aberrant specific rewards in addiction. A major source glutamate driving striatal activity is rostral intralaminar nuclei thalamus (rILN). Yet, information that relayed support action unknown. Here we discovered rILN neurons projecting DS integrated from subcortical and cortical sources these rILN→DS...