A5073086931- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- Cardiovascular and exercise physiology
- Inhalation and Respiratory Drug Delivery
- Nutrition and Health in Aging
- Cardiovascular and Diving-Related Complications
- Parathyroid Disorders and Treatments
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Injury Epidemiology and Prevention
- Ultrasound in Clinical Applications
- Genetic Syndromes and Imprinting
- Protease and Inhibitor Mechanisms
- Exercise and Physiological Responses
- Healthcare Policy and Management
- Congenital Heart Disease Studies
- Erythropoietin and Anemia Treatment
- Balance, Gait, and Falls Prevention
- GDF15 and Related Biomarkers
- Proteoglycans and glycosaminoglycans research
- Dysphagia Assessment and Management
- Physical Activity and Health
AstraZeneca (United Kingdom)
2021-2024
University of Miami
2022
Royal Brompton & Harefield NHS Foundation Trust
2010-2022
Royal Brompton Hospital
2012-2022
Age UK
2019
GlaxoSmithKline (United Kingdom)
2019
Imperial College London
2012-2016
University of Virginia
2012-2016
Heart of England NHS Foundation Trust
2016
Medical Research Council
2014
<h3>Background</h3> Moving from sitting to standing is a common activity of daily living. The five-repetition sit-to-stand test (5STS) lower limb function that measures the fastest time taken stand five times chair with arms folded. 5STS has been validated in healthy community-dwelling adults, but data chronic obstructive pulmonary disease (COPD) populations are lacking. <h3>Aims</h3> To determine reliability, validity and responsiveness patients COPD. <h3>Methods</h3> Test-retest...
Quadriceps weakness is an important complication of advanced chronic obstructive pulmonary disease (COPD) but few data exist concerning muscle bulk in early disease. We hypothesised that quadriceps bulk, measured by ultrasound rectus femoris cross-sectional area (USRF CSA ), would be reduced mild, as well advanced, COPD compared with controls, and correlate physical activity. 161 patients stable 40 healthy subjects had a measurement USRF wore multisensor armband to record was Global...
In community-dwelling older adults, usual gait speed over 4 m (4MGS) consistently predicts greater risk of adverse health outcomes. The aims the present study were to assess reliability 4MGS and relationship with established outcome measures in chronic obstructive pulmonary disease (COPD). Test-retest interobserver measured 80 58 COPD patients, respectively. 586 4MGS, as well forced expiratory volume 1 s (FEV1), incremental shuttle walk (ISW), Medical Research Council (MRC) dyspnoea scale St...
Abstract Background Loss of muscle mass is a co‐morbidity common to range chronic diseases including obstructive pulmonary disease (COPD). Several systemic features COPD increased inflammatory signalling, oxidative stress, and hypoxia are known increase the expression growth differentiation factor‐15 (GDF‐15), protein associated with wasting in other diseases. We therefore hypothesized that GDF‐15 may contribute COPD. Methods determined serum patients analysed association exercise...
Abstract Background Japanese guidelines recommend triple inhaled corticosteroid (ICS)/long-acting muscarinic antagonist (LAMA)/long-acting β 2 -agonist (LABA) therapy in patients with chronic obstructive pulmonary disease (COPD) and no concurrent asthma diagnosis who experience frequent exacerbations have blood eosinophil (EOS) count ≥ 300 cells/mm 3 , COPD continuing/worsening symptoms despite receiving dual ICS/LABA therapy. These post-hoc analyses of the KRONOS study without an diagnosis,...
We described physical activity measures and hourly patterns in patients with chronic obstructive pulmonary disease (COPD) after stratification for generic COPD-specific characteristics and, based on multiple measures, we identified clusters of patients. In total, 1001 COPD (65% men; age, 67 years; forced expiratory volume the first second [FEV 1 ], 49% predicted) were studied cross-sectionally. Demographics, anthropometrics, lung function clinical data assessed. Daily analysed from a...
Chronic obstructive pulmonary disease (COPD) is associated with increased risk of cardiovascular and cardiopulmonary events. In the Phase III, 52-week ETHOS trial (NCT02465567), triple therapy budesonide/glycopyrrolate/formoterol fumarate (BGF) reduced rates moderate/severe exacerbations all-cause mortality versus dual glycopyrrolate/formoterol (GFF) or budesonide/formoterol (BFF). However, effect BGF on events GFF remains unevaluated. Further, time to first severe exacerbation has not been reported.
Background: The COPD Assessment Test (CAT) is a recently introduced instrument to assess health-related quality of life in COPD. We aimed evaluate the longitudinal change CAT following Pulmonary Rehabilitation (PR), and test relationship between CRQ-Self Report (SR) over time. hypothesised that would show similar responsiveness PR as CRQ-SR both short medium-term. Methods: 118 patients completed an eight-week outpatient multidisciplinary programme. CAT, incremental shuttle walk (ISW) were...
Abstract Background Mitochondrial damage and dysfunction have been reported in airway quadriceps muscle cells of patients with chronic obstructive pulmonary disease (COPD). We determined the concomitance mitochondrial these COPD. Methods Bronchial biopsies were obtained from never- ex-smoker volunteers COPD (GOLD Grade 2) same addition to at GOLD 3/4 for measurement function. Results Decreased membrane potential (ΔΨm), increased reactive oxygen species (mtROS) decreased superoxide dismutase...
If effective, respiratory muscle training (RMT) is surely the most unfortunate therapy in medicine. Over 35 years have elapsed since seminal work of Leith and Bradley (Leith & Bradley, 1976), yet despite being relatively cheap free side effects, RMT finds limited favour beyond specialist sporting activities remains tool enthusiast. Several caveats require consideration when assessing whether improves exercise tolerance. The first can improve performance healthy humans and, as claimed, a...
The COPD Assessment Test (CAT) is a recently introduced, simple-to-use health status instrument that takes less time to complete than better-established instruments. In chronic obstructive pulmonary disease (COPD) patients, the CAT improves with rehabilitation (PR), and changes correlate improvements in longer-established instruments such as Chronic Respiratory Questionnaire (CRQ). Increasing numbers of non-COPD patients are referred for PR, but it not known whether responsive PR these...
Purpose: Blood eosinophil (EOS) count can guide treatment decisions for chronic obstructive pulmonary disease (COPD). In the 52-week ETHOS study (NCT02465567), budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF) triple therapy at two inhaled corticosteroid doses reduced moderate/severe exacerbation rates and improved lung function, symptoms, disease-related quality of life (QoL) versus dual with glycopyrronium/formoterol (GFF) or budesonide/formoterol (BFF) in patients...
In the Phase III ETHOS study (NCT02465567), budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF) triple therapy at two inhaled corticosteroid (ICS) doses reduced moderate/severe exacerbation rates and improved symptoms, health-related quality of life (HRQoL), lung function versus glycopyrronium/formoterol (GFF) or budesonide/formoterol (BFF) dual in patients with moderate-to-very-severe chronic obstructive pulmonary disease (COPD). Here, we assessed whether benefit for BGF GFF was...
The 100% oxygen shunt test for detecting right-to-left anatomical shunting was originally described 70 years ago. However, its clinical value is not yet established. We conducted an audit in 80 patients undergoing the between 1996 and 2012 a tertiary referral centre. A significant difference (p=0.02) existed median percentages where identified (10.2%) absent (5.0%). area under curve ROC plot 0.70. percentage of 8.3 had sensitivity 80% specificity 75% detection anatomic shunt. conclude...
Background: Patent foramen ovale (PFO) is a common finding in adults. A PFO associated with right to left shunting but its importance the aetiology of hypoxia early COPD remains uncertain, although it has not proved possible demonstrate role for PFOs pati
Quadriceps dysfunction is important in chronic obstructive pulmonary disease (COPD), with an associated increased proportion of type II fibers. Investigation protein synthesis and degradation has yielded conflicting results, possibly due to study whole biopsy samples, whereas signaling may be fiber-specific. Our objective was develop a method for fiber-specific gene expression analysis.12 COPD 6 healthy subjects underwent quadriceps biopsy. Cryosections were immunostained fibers, which...
Traumatic penile amputation is a rare clinical situation. We report case of self-inflicted in patient with psychosis and discuss the surgical management. Acute management largely entails stabilization preparation for surgery, where options include replantation amputated penis versus closure remaining stump, depending on viability penis. Although best option, it often not possible thus wound acceptable
<h3>Introduction</h3> The Short Physical Performance Battery (SPPB) is a simple objective assessment tool developed by the National Institute on Ageing for evaluating lower extremity function in older persons. It comprises tests of standing balance, normal gait speed and timed sit-to-stand with maximum score 12, predicts nursing home admission rates mortality. Lower dysfunction well recognised COPD, hence SPPB may be useful functional outcome measure COPD patients. Pulmonary rehabilitation...