A5007645953- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Advanced Chemical Sensor Technologies
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Cystic Fibrosis Research Advances
- Occupational exposure and asthma
- Metabolomics and Mass Spectrometry Studies
- Neuroscience of respiration and sleep
- Food Allergy and Anaphylaxis Research
- COVID-19 and Mental Health
- Tracheal and airway disorders
- Allergic Rhinitis and Sensitization
- Pharmaceutical studies and practices
- Historical and Religious Studies of Rome
- Eosinophilic Esophagitis
- Family and Patient Care in Intensive Care Units
- Health, psychology, and well-being
- Child and Adolescent Health
- Innovations in Medical Education
University of Padua
2016-2025
Metropolitana Milanese (Italy)
2024
Città della Speranza Foundation
2016-2020
University of Verona
2003-2019
Ca' Foscari University of Venice
2016
ENT and Allergy
2013
University of Virginia Health System
2006
University of Parma
2003-2006
University of Virginia
2006
Instituto Alexander Fleming
2004
Rationale: Metabolomic analysis provides biochemical profiles of low-molecular-weight endogenous metabolites in biological fluids.Objectives: The aim this study was to assess the feasibility nuclear magnetic resonance (NMR)–based metabolomic applied exhaled breath condensate (“breathomics”). Information coming from NMR spectra analyzed with a view establish variables that best discriminate between children asthma and healthy children.Methods: Twenty-five (17 persistent treated inhaled...
Rationale: Asthma treatment might improve when inhaled steroids are titrated on airway inflammation. Fractional exhaled nitric oxide (FeNO0.05), a marker of eosinophilic inflammation, can be measured at home.Objectives: We assessed daily FeNO0.05 telemonitoring in the management childhood asthma.Methods: Children with atopic asthma (n = 151) were randomly assigned to two groups: plus symptom monitoring, or monitoring symptoms only. All patients scored an electronic diary over 30 weeks; 77...
Oxidative stress is implicated in the pathogenesis of asthma, and clinical studies show an imbalance level oxidants to antioxidants subjects with asthma. Aldehydes glutathione are examples biomarkers oxidant-induced damage antioxidant status respectively. In study, we applied analytical techniques based on liquid chromatography for assessment aldehydes exhaled breath condensate children asthma control without Twelve were evaluated at exacerbation after 5 days therapy prednisone. At...
Abstract Background Asthma is a heterogeneous disease and its different phenotypes need to be better characterized from biochemical‐inflammatory standpoint. This study aimed apply the metabolomic approach exhaled breath condensate (breathomics) discriminate asthma phenotypes, with particular focus on severe in children. Methods In this cross‐sectional study, we recruited 42 asthmatic children (age, 8–17 years): 31 nonsevere (treated inhaled steroids or not) 11 asthma. Fifteen healthy were...
Objective Bronchopulmonary dysplasia (BPD) is a serious complication associated with preterm birth. A growing body of evidence suggests role for prenatal factors in its pathogenesis. Metabolomics allows simultaneous characterization low molecular weight compounds and may provide picture such complex condition. The aim this study was to evaluate whether an unbiased metabolomic analysis amniotic fluid (AF) can be used investigate the risk spontaneous delivery (PTD) BPD development offspring....
Recent advances in perinatal care and neonatal respiratory therapy have led to a new phenotype of bronchopulmonary dysplasia ("new BPD"). The long-term outcome this form BPD has yet be adequately described. Aim study was provide longitudinal data on lung function an unselected cohort children born extremely premature (EP) with low birth weight the post-surfactant era.Respiratory assessed twice (at 8 12 years) 48 at gestational age <28 weeks <1,000 g. Twenty-eight them had (oxygen-dependency...
Abstract Background Many children of preschool age present with recurrent wheezing. Most them outgrow their symptoms, while some have early‐onset asthma. Aim this prospective preliminary study was to apply a metabolomic approach see whether biochemical‐metabolic urinary profiles can role in the early identification Methods Preschool wheezing were recruited and followed up for 3 years, after which they classified as cases transient or A urine sample collected at recruitment analyzed using...
Abstract Knowledge on multiple interdependences between quality of life (QoL) and behavioural problems in relation to asthma severity control is undetermined. The aims the study were: (i) assess relationship QoL with (ii) predict children’s “abnormal/borderline” status variation QoL. For these purposes a multicenter case-control 47 Severe Asthma (SA) 94 Moderate (MA) children was performed. MIMIC approach applied investigate effect SA non-controlled (NC) disorders. Logistic regression used...
Background: The dysregulation of airway pH control may have a role in asthma pathophysiology. measurement exhaled breath condensate (EBC) and ammonia levels be used as noninvasive method to study acid–base status the asthmatics. Methods: Exhaled from 29 allergic stable asthmatic children 13 healthy controls was collected by cooling air during tidal breathing. Ammonia measured high‐performance liquid chromatography with fluorescence detection. after deaeration EBC samples bubbling argon. also...
Acute exposure to chlorine gas results in respiratory impairment, but few data are available on the pathobiology of underlying lung damage.To assess function and potential damage pathways acute phase longitudinally over a 15-mo follow-up after exposure.Ten previously healthy children were accidentally exposed at swimming pool because an erroneous servicing procedure. The fraction nitric oxide exhaled air (Fe(NO)), breath condensate compounds, serum Clara cell-specific protein CC16 repeatedly...
The endogenous bronchodilator, <i>S</i>-nitrosoglutathione (GSNO), increases expression, maturation, and function of both the wild-type ΔF508 mutant cystic fibrosis transmembrane conductance regulatory protein (CFTR). Though transcriptional mechanisms action have been identified, GSNO seems also to post-transcriptional effects on CFTR maturation. Here, we report that 1) is only one a class <i>S</i>-nitrosylating agents that, at low micromolar concentrations, increase expression maturation;...
Quality of life is negatively affected in children with food allergy. Oral immunotherapy an approach to allergy that leads patient desensitization by administering gradually increasing amounts a given allergen. The aim this pilot study evaluate how oral affects quality allergic cow milk proteins. Thirty (aged 3–12 years) were recruited. Their parents provided validated disease specific questionnaire (the – parent form, FAQLQ-PF) before and again 2 months after completing protocol milk. A...