A5040334922- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Cystic Fibrosis Research Advances
- Respiratory viral infections research
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dysphagia Assessment and Management
- Gastroesophageal reflux and treatments
- Emergency and Acute Care Studies
- Child Nutrition and Feeding Issues
- Child and Adolescent Health
- Infant Health and Development
- Respiratory Support and Mechanisms
- Voice and Speech Disorders
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Delphi Technique in Research
- Family and Patient Care in Intensive Care Units
- Bacterial Infections and Vaccines
- Childhood Cancer Survivors' Quality of Life
- Health Sciences Research and Education
- Esophageal and GI Pathology
Charles Darwin University
2016-2025
Menzies School of Health Research
2016-2025
Queensland University of Technology
2016-2025
National Health and Medical Research Council
2021-2025
Queensland Children’s Hospital
2016-2025
Royal Darwin Hospital
2010-2025
University of California, Los Angeles
2011-2025
Amgen (United States)
2025
Royal Children's Hospital
2010-2024
Taipei Medical University-Shuang Ho Hospital
2020-2023
The monitoring of fetal weight is an important aspect antenatal care. To construct individually adjustable standard, we developed a model to link the predicted birth curve which outlines how this be reached in uncomplicated pregnancy. A formula was derived describes median at each gestation as proportion optimal term weight, and also defines 90th 10th centile curves normal limits. We analyzed database 38,114 singleton, routine ultrasound-dated pregnancies resulting deliveries. By stepwise...
Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, dendritic cell differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU.1 or Spi-B. How these IRFs target genes in most T cells is enigmatic given the absence of specific Ets partners. Chromatin immunoprecipitation sequencing helper 17 (T(H)17) reveals that IRF4 targets sequences enriched for activating protein 1 (AP-1)-IRF (AICEs) co-bound BATF, an AP-1 required T(H)17, BATF bind...
Tracheomalacia and tracheobronchomalacia may be primary abnormalities of the large airways or associated with a wide variety congenital acquired conditions. The evidence on diagnosis, classification management is scant. There no universally accepted severity. Clinical presentation includes early-onset stridor fixed wheeze, recurrent infections, brassy cough even near-death attacks, depending site severity lesion. Diagnosis usually made by flexible bronchoscopy in free-breathing child but...
There is increasing awareness of bronchiectasis in children and adolescents, a chronic pulmonary disorder associated with poor quality life for the child/adolescent their parents, recurrent exacerbations, costs to family health systems. Optimal treatment improves clinical outcomes. Several national guidelines exist, but there are no international guidelines. The European Respiratory Society (ERS) Task Force management paediatric sought identify evidence-based (investigation treatment)...
Abstract This position statement, updated from the 2015 guidelines for managing Australian and New Zealand children/adolescents adults with chronic suppurative lung disease (CSLD) bronchiectasis, resulted systematic literature searches by a multi‐disciplinary team that included consumers. The main statements are: Diagnose CSLD bronchiectasis early; this requires awareness of symptoms its co‐existence other respiratory diseases (e.g., asthma, obstructive pulmonary disease). Confirm chest...
TASL is an immune adaptor that binds to the solute carrier SLC15A4 and facilitates activation of transcription factor IRF5 during Toll-like receptor (TLR) signaling. Similar SLC15A4, single nucleotide polymorphisms (SNPs) within have been implicated in increased susceptibility systemic lupus erythematosus (SLE) patients. However, biological function vivo how SLE-associated SNPs increase disease risk unknown. Here we report mice deficient Tasl lack responses TLR7/9 stimulation are protected...