A5014719808- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Metabolomics and Mass Spectrometry Studies
- Dementia and Cognitive Impairment Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pediatric health and respiratory diseases
- Smoking Behavior and Cessation
- Alzheimer's disease research and treatments
- Respiratory Support and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Delphi Technique in Research
- Sphingolipid Metabolism and Signaling
- Sarcoidosis and Beryllium Toxicity Research
- Intensive Care Unit Cognitive Disorders
- Extracellular vesicles in disease
- Cannabis and Cannabinoid Research
- Maternal Mental Health During Pregnancy and Postpartum
- IL-33, ST2, and ILC Pathways
- Advanced Proteomics Techniques and Applications
- Isotope Analysis in Ecology
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- Bacillus and Francisella bacterial research
- Autoimmune and Inflammatory Disorders
New York University
2023-2024
VA Boston Healthcare System
2024
University of Colorado Denver
2014-2023
National Jewish Health
2014-2023
Colorado School of Public Health
2014-2023
University of Colorado Anschutz Medical Campus
2023
Pulmonary and Critical Care Associates
2019
SleepMed
2019
Indiana University – Purdue University Indianapolis
2016
Indiana University School of Medicine
2016
Chronic obstructive pulmonary disease (COPD) occurs in a minority of smokers and is characterized by intermittent exacerbations clinical subphenotypes such as emphysema chronic bronchitis. Although sphingolipids class are implicated the pathogenesis COPD, particular sphingolipid species associated with COPD remain unknown.To use mass spectrometry to determine which plasma COPD.One hundred twenty-nine current former from COPDGene cohort had 69 distinct detected targeted spectrometry. Of...
Novel proteomics platforms, such as the aptamer-based SOMAscan platform, can quantify large numbers of proteins efficiently and cost-effectively are rapidly growing in popularity. However, comparisons to conventional immunoassays remain underexplored, leaving investigators unsure when cross-assay appropriate. The correlation results from with relative protein quantification is explored by SOMAscan. For 63 assessed two chronic obstructive pulmonary disease (COPD) cohorts, subpopulations...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous characterized by multiple subtypes and variable progression. Blood biomarkers have been variably associated with subtype, severity, Just as combined clinical variables are more highly predictive of outcomes than individual variables, we hypothesized that may be informative to predict subtypes, progression, mortality. Fibrinogen, C-Reactive Protein (CRP), surfactant protein D (SP-D), soluble Receptor for Advanced Glycation...
Abstract Circulating endothelial microparticles (EMPs) are emerging as biomarkers of chronic obstructive pulmonary disease (COPD) in individuals exposed to cigarette smoke (CS), but their mechanism release and function remain unknown. We assessed biochemical functional characteristics EMPs circulating (cMPs) released by CS. CS exposure was sufficient increase microparticle levels plasma humans mice supernatants primary human lung microvascular cells. CS-released contained predominantly...
Rationale: Chronic obstructive pulmonary disease exacerbations are associated with progression, higher healthcare cost, and increased mortality. Published predictors of future include previous exacerbation, airflow obstruction, poor overall health, home oxygen use, gastroesophageal reflux.Objectives: To determine the value adding blood biomarkers to clinical variables predict exacerbations.Methods: Subjects from SPIROMICS (Subpopulations Intermediate Outcomes Measures in COPD Study) (n =...
Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there fewer studies that have investigated multiple and replicated in large well-characterized cohorts of susceptible current former smokers. We two MSD multiplex panels measure 9 cytokines chemokines 2123 subjects from COPDGene 1117 SPIROMICS. These included: interleukin (IL)-2, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, eotaxin/CCL-11,...
Chronic obstructive pulmonary disease (COPD) comprises multiple phenotypes such as airflow obstruction, emphysema, and frequent episodes of acute worsening respiratory symptoms, known exacerbations. The goal this pilot study was to test the usefulness unbiased metabolomics transcriptomics approaches delineate biological pathways associated with COPD outcomes. Blood collected from 149 current or former smokers without separated into peripheral blood mononuclear cells (PBMC) plasma. PBMCs...
Abstract Sarcoidosis is a complex systemic disease. Our study aimed to (1) identify novel alleles associated with sarcoidosis susceptibility; (2) provide an in-depth evaluation of HLA and susceptibility (3) integrate genetic transcription data risk loci that may more directly impact disease pathogenesis. We report genome-wide association 1335 cases 1264 controls European descent (EA) investigate in African Americans (AA: 1487 1504 controls). The EA AA cohort was recruited from multiple...
The use of antidepressants in major depressive disorder (MDD) has been reported to influence long-term risk Alzheimer's disease (AD) and AD-related dementias (AD/ADRD), but studies are conflicting.
Abstract Background An elevated neutrophil–lymphocyte ratio (NLR) in blood has been associated with Alzheimer’s disease (AD). However, an NLR also implicated many other conditions that are risk factors for AD, prompting investigation into whether the is directly linked AD pathology or a result of underlying comorbidities. Herein, we explored relationship between and biomarkers cerebrospinal fluid (CSF) cognitively unimpaired (CU) subjects. Adjusting sociodemographics, APOE4, common...
Background: Small studies have recently suggested that there are specific plasma metabolic signatures in chronic obstructive pulmonary disease (COPD), but been no large comprehensive study of metabolomic COPD also integrate genetic variants. Materials and Methods: Fresh frozen from 957 non-Hispanic white subjects COPDGene was used to quantify 995 metabolites with Metabolon's global metabolomics platform. Metabolite associations five phenotypes (chronic bronchitis, exacerbation frequency,...
Background: Marijuana is often smoked via a filterless cigarette and contains similar chemical makeup as tobacco. There are few publications describing usage patterns respiratory risks in older adults or those with chronic obstructive pulmonary disease (COPD). Methods: A cross-section
This observational study catalogues the overlap in metabolites between matched bronchoalveolar lavage fluid (BALF) and plasma, identifies degree of congruence these metabolomes human mouse, determines how molecules may change response to cigarette smoke (CS) exposure. Matched BALF plasma was collected from mice (ambient air or CS-exposed) humans (current former smokers), analyzed using mass spectrometry. There were 1155 compounds common all 4 sample types; fatty acyls glycerophospholipids...
Oxidative stress is important in the pathogenesis of allergic asthma. Extracellular superoxide dismutase (EC-SOD; SOD3) major antioxidant lungs, but its role asthma unknown. Here we report that asthmatics have increased SOD3 transcript levels sputum and a single nucleotide polymorphism (SNP) (R213G; rs1799895) changes lung distribution EC-SOD, decreases likelihood asthma-related symptoms. Knockin mice analogous to human R213G SNP had lower airway hyperresponsiveness, inflammation, mucus...
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous characterised by airflow obstruction and other morbidities such as respiratory symptoms, reduced physical activity frequent bronchodilator use. Recent advances in personal digital monitoring devices can permit continuous collection of these data COPD patients, but the relationships among them are not well understood. Methods 184 individuals from single centre COPDGene cohort agreed to participate this 3-week...
Prolonged cigarette smoking (CS) causes chronic obstructive pulmonary disease (COPD), a prevalent serious condition that may persist or progress after cessation. To provide insight into how CS triggers COPD, we investigated temporal patterns of lung transcriptome expression and systemic metabolome changes induced by exposure Whole RNA-seq data was analyzed at transcript exon levels from C57Bl/6 mice exposed to for 1- 7 days, 3-, 6-, 9 months, 6 months followed 3 cessation using age-matched...