Katherine Pratte
A5019860007- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic Associations and Epidemiology
- Delphi Technique in Research
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Health and Risk Factors
- Bioinformatics and Genomic Networks
- Protease and Inhibitor Mechanisms
- Diabetes Management and Education
- Epigenetics and DNA Methylation
- Gene expression and cancer classification
- Respiratory and Cough-Related Research
- Chronic Disease Management Strategies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Occupational and environmental lung diseases
- Advanced Proteomics Techniques and Applications
- Air Quality and Health Impacts
- Atherosclerosis and Cardiovascular Diseases
- Health Promotion and Cardiovascular Prevention
- Gut microbiota and health
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
National Jewish Health
2017-2025
University of Colorado Denver
2009-2025
University of California, Irvine
2018-2019
University of Colorado Anschutz Medical Campus
2010-2018
Native Health
2014-2018
Colorado School of Public Health
2008-2018
Katherine Hospital
2016-2017
Duke Medical Center
2017
Brigham and Women's Hospital
2017
Columbia University
2017
Increasing awareness of the prevalence and significance Preserved Ratio Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for Chronic Obstructive Lung Disease (GOLD)-unclassified spirometry, has expanded body knowledge on cross-sectional risk factors. However, longitudinal studies PRISm remain limited.
Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified substantial number individuals without COPD who suffer from respiratory symptoms and/or increased There is clear need for an expanded definition that linked to physiologic, structural (computed tomography [CT]) clinical disease. Using data the Genetic Epidemiology study (COPDGene
Novel proteomics platforms, such as the aptamer-based SOMAscan platform, can quantify large numbers of proteins efficiently and cost-effectively are rapidly growing in popularity. However, comparisons to conventional immunoassays remain underexplored, leaving investigators unsure when cross-assay appropriate. The correlation results from with relative protein quantification is explored by SOMAscan. For 63 assessed two chronic obstructive pulmonary disease (COPD) cohorts, subpopulations...
Rationale: The decades-long progression of chronic obstructive pulmonary disease (COPD) renders identifying different trajectories challenging.Objectives: To identify subtypes patients with COPD distinct longitudinal patterns using a novel machine-learning tool called "Subtype and Stage Inference" (SuStaIn) to evaluate the utility SuStaIn for patient stratification in COPD.Methods: We applied cross-sectional computed tomography imaging markers 3,698 Global Initiative Chronic Obstructive Lung...
Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary (COPD). COPD exacerbations not only contribute to progression but may also elevate risk of CVD. This study aimed determine whether increase subsequent CVD events using up 15 years prospective longitudinal follow-up data from COPDGene (Genetic Epidemiology Chronic Obstructive Pulmonary Disease) study.
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence mLOY associated with altered blood cell counts and increased risk Alzheimer disease, solid tumors, other age-related diseases. We sought to gain a better understanding genetic drivers phenotypes through analyses whole-genome sequencing (WGS) large set genetically diverse males from Trans-Omics for Precision Medicine (TOPMed) program. show that haplotype-based calling methods can be...
Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants (pQTL) and phenotypes. Here, we examined 2,157 proteins measured on both SomaScan 7k Olink Explore 3072 across 1,930 participants similarity to European, African, East Asian, Admixed American ancestry references. Inter-platform correlation coefficients for these followed a bimodal distribution (median r=0.30). Protein measures were associated (pQTLs),...
Individuals at risk for chronic obstructive pulmonary disease (COPD) but without spirometric airflow obstruction can have respiratory symptoms and structural lung on chest computed tomography. Current guidelines recommend COPD diagnostic schemas that do not incorporate imaging abnormalities. To determine whether a multidimensional schema includes tomographic abnormalities identifies additional individuals with disease. This cohort study included 2 longitudinal cohorts: the Genetic...
Rationale: Knowledge on biomarkers of interstitial lung disease is incomplete. Interstitial abnormalities (ILAs) are radiologic changes that may present in its early stages. Objectives: To uncover blood proteins associated with ILAs using large-scale proteomics methods. Methods: Data from two prospective cohort studies, the AGES-Reykjavik (Age, Gene/Environment Susceptibility–Reykjavik) study (N = 5,259) for biomarker discovery and COPDGene (Genetic Epidemiology COPD) 4,899) replication,...
Cigarette smoking contributes to the risk of death through different mechanisms.
Evidence for long-term translational effectiveness of lifestyle interventions in minority populations is scarce. This article reports outcomes, up to 10 years, such an intervention prevent diabetes American Indian and Alaska Native (AI/AN) communities.
Rationale: The American Thoracic Society (ATS)/European Respiratory defines a positive bronchodilator response (BDR) by composite of BDR in either forced expiratory volume 1 second (FEV1) and/or vital capacity (FVC) greater than or equal to 12% and 200 ml (ATS-BDR). We hypothesized that ATS-BDR components would be differentially associated with important chronic obstructive pulmonary disease (COPD) outcomes. Objectives: To examine whether are clinical, functional, radiographic features COPD....
Background The clinical significance of visually evident emphysema on CT images in individuals without spirometric evidence chronic obstructive pulmonary disease (COPD) by current diagnostic criteria is, to the knowledge authors, unknown. Purpose To evaluate whether participants with at were more likely have progressive and increased mortality 5 years compared those visual emphysema. Materials Methods This secondary analysis prospective Genetic Epidemiology COPD study evaluated or former...
Multiple studies have demonstrated an increased risk of chronic obstructive pulmonary disease (COPD) in heterozygous carriers the AAT (alpha-1 antitrypsin) Z allele. However, it is not known if MZ subjects with COPD are phenotypically different from noncarriers (MM genotype) COPD.
Chronic obstructive pulmonary disease (COPD) and idiopathic fibrosis (IPF) are characterized by shared exposures clinical features, but distinct genetic pathologic features exist. These have not been well-studied using large-scale gene expression datasets. We hypothesized that there divergent gene, pathway, cellular signatures between COPD IPF.We performed RNA-sequencing on lung tissues from individuals with IPF (n = 231) 377) compared to control 267), defined as normal spirometry. grouped...