A5075795589- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- CO2 Sequestration and Geologic Interactions
- Geothermal Energy Systems and Applications
- Medical Imaging and Pathology Studies
- Methane Hydrates and Related Phenomena
- Geophysical and Geoelectrical Methods
- Occupational and environmental lung diseases
- Carbon Dioxide Capture Technologies
- Long-Term Effects of COVID-19
- Geophysics and Gravity Measurements
- Pulmonary Hypertension Research and Treatments
- Genetic Associations and Epidemiology
- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
- COVID-19 and Mental Health
- Cardiovascular Function and Risk Factors
- Respiratory viral infections research
- Asthma and respiratory diseases
- Bioinformatics and Genomic Networks
- Hydraulic Fracturing and Reservoir Analysis
- Groundwater flow and contamination studies
- Catalysts for Methane Reforming
- COVID-19 diagnosis using AI
- Telomeres, Telomerase, and Senescence
University of Iceland
2012-2025
Reykjavík University
2023-2025
National University Hospital of Iceland
2022-2025
Icelandic Heart Association
2018-2024
Faculty (United Kingdom)
2018-2022
Iceland GeoSurvey
2008-2013
Oregon State University
1986
Landsvirkjun (Iceland)
1985
Rationale: Interstitial lung abnormalities (ILA) are radiologic on chest computed tomography scans that have been associated with an early or mild form of pulmonary fibrosis. Although ILA progression, it is not known if specific imaging patterns progression risk mortality.Objectives: To determine the role death and progression.Methods: (and pattern) were assessed in 5,320 participants from AGES-Reykjavik Study, was 3,167 participants. Multivariable logistic regression used to assess factors...
Abstract With the growing number of genetic association studies, genotype-phenotype atlas has become increasingly more complex, yet functional consequences most disease associated alleles is not understood. The measurement protein level variation in solid tissues and biofluids integrated with variants offers a path to deeper insights. Here we present large-scale proteogenomic study 5,368 individuals, revealing 4,035 independent associations between 2,091 serum proteins, which 36% are...
In situ mineral carbonation is facilitated by aqueous-phase chemical reactions with dissolved CO2. Evidence from the laboratory and field shows that limiting factors for in are dissolution rate of CO2 into aqueous phase release divalent cations basic silicate minerals. Up to now, pilot storage projects commercial operations have focused on injection anthropogenic as a supercritical depleted oil gas reservoirs or deep saline aquifers limited potential mineralization. The CarbFix Pilot Project...
The storage of large volumes industrial CO2 emissions in deep geological formations is one the most promising climate mitigation options. long-term retention time and environmental safety are defined by interaction injected with reservoir fluids rocks. Finding a solution that long lasting, thermodynamically stable environmentally benign would be ideal. Storage as solid magnesium or calcium carbonates basaltic rocks may provide such solution. Basaltic rocks, which primarily consist silicate...
Rationale: Knowledge on biomarkers of interstitial lung disease is incomplete. Interstitial abnormalities (ILAs) are radiologic changes that may present in its early stages. Objectives: To uncover blood proteins associated with ILAs using large-scale proteomics methods. Methods: Data from two prospective cohort studies, the AGES-Reykjavik (Age, Gene/Environment Susceptibility–Reykjavik) study (N = 5,259) for biomarker discovery and COPDGene (Genetic Epidemiology COPD) 4,899) replication,...
The identification of protein targets that exhibit anti-aging clinical potential could inform interventions to lengthen the human health span. Most previous proteomics research has been focused on chronological age instead longevity. We leveraged two large population-based prospective cohorts with long follow-ups evaluate proteomic signature longevity defined by survival 90 years age. Plasma was measured using a SOMAscan assay in 3067 participants from Cardiovascular Health Study (discovery...
An increased incidence of lung cancer is well known among patients with idiopathic pulmonary fibrosis. It not whether interstitial abnormalities, i.e. early fibrotic changes the lung, are a risk factor for in general population. The study's objective was to assess abnormalities were associated diagnoses of, and mortality from, other cancers. Data from AGES-Reykjavik study, cohort 5764 older Icelandic adults, used. Outcome data ascertained electronic medical records. Gray's tests, Cox...
Background Interstitial lung abnormalities (ILA) share many features with idiopathic pulmonary fibrosis; however, it is not known if ILA are associated decreased mean telomere length (MTL). Methods Telomere was measured quantitative PCR in the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) and Age Gene/Environment Susceptibility Reykjavik (AGES-Reykjavik) cohorts Southern blot analysis used Framingham Heart Study (FHS). Logistic linear regression were to assess...
Rationale First-degree relatives of patients with pulmonary fibrosis (relatives) are at high risk for interstitial lung abnormalities (ILA), highlighting the need biomarkers prediction. We aimed to identify blood proteins associated and predictive ILA among fibrosis. Methods Relatives enrolled in two independent cohorts had protein levels measured using an aptamer-based proteomic platform. was assessed CT scans per Fleischner Society recommendations. Protein associations were regression,...
Abstract Aims Atrial fibrillation (AF) is associated with high risk of comorbidities and mortality. Our aim was to examine causal predictive relationships between 4137 serum proteins incident AF in the prospective population-based Age, Gene/Environment Susceptibility-Reykjavik (AGES-Reykjavik) study. Methods results The study included 4765 participants, whom 1172 developed AF. Cox proportional hazards regression models were fitted for baseline protein measurements adjusting known factors....
In two population-based cohorts, we did not find an independent relationship between albuminuria and ILA, with age emerging as a key confounding factor. Our results suggest there may be common systemic pathology of aging that underlies ILA. Background Pulmonary microvascular dysfunction has been suggested to early feature interstitial lung changes, which precede disease (ILD). The prospective association albuminuria, marker endothelial dysfunction, abnormalities (ILA) high-attenuation areas...
Abstract Mineral sequestration is among several promising methods of CO 2 reduction. It involves incorporation into a solid phase via precipitation carbonate minerals. A prerequisite to the availability aqueous metal cations and network porous media for fluid flow water-rock interactions. The Hellisheidi-Threngsli lava field in SW Iceland comprises ideal conditions studying feasibility permanent storage as minerals basaltic rocks. In this paper we report on tracer test conducted between two...
Rationale: Higher blood monocyte counts are associated with worse survival in adults clinically diagnosed pulmonary fibrosis. Their association the development and progression of interstitial lung abnormalities (ILA) humans is unknown. Objectives: We evaluated associations count, other immune cell types, ILA, high-attenuation areas, FVC four independent cohorts. Methods: included participants measured computed tomographic (CT) imaging enrolled MESA (Multi-Ethnic Study Atherosclerosis, n =...
Background Interstitial lung abnormalities (ILAs) are associated with increased mortality. It is unclear whether multimorbidity accounts for the mortality association or how strongly ILA relative to other common age-associated diseases. We determined of all-cause adjusted multimorbidity, compared and prevalent cardiovascular disease (CVD), diabetes mellitus, chronic kidney disease, obstructive pulmonary cancer also between these Methods measured (none, indeterminant, definite) using blinded...
A decline in forced expiratory volume (FEV1) is a hallmark of respiratory diseases that are an important cause morbidity among the elderly. While some data exist on biomarkers related to FEV1, we sought do systematic analysis causal relations with FEV1. Data from population-based AGES-Reykjavik study were used. Serum proteomic measurements done using 4782 DNA aptamers (SOMAmers). 1479 participants spirometric used assess association SOMAmer FEV1 linear regression. Bi-directional two-sample...
Docosahexaenoic acid (DHA), an ω-3 polyunsaturated fatty acid, attenuates interstitial lung disease (ILD) in experimental models, but human studies are lacking. We examined associations of circulating levels DHA and other acids with hospitalization death due to ILD over 12 years the Multi-Ethnic Study Atherosclerosis (MESA; n = 6,573). cross-sectional CT abnormalities MESA (2000-2012; 6,541), Framingham Heart (2005-2011; 3,917), Age, Gene/Environment Susceptibility-Reykjavik (AGES-Reykjavik)...
The term interstitial lung abnormalities (ILA) was coined to define a precursory stage of idiopathic pulmonary fibrosis and encompasses set radiological changes seen in diseases (ILD) but are often lesser magnitude [1]. ILA have been associated with age, many environmental genetic risk factors symptoms [1, 2]. also reduced exercise capacity self-reported health function [3–5]. Reductions objectively measured physical <http://ow.ly/azAW30kMhqv>
Geothermal reinjection involves injecting energy-depleted fluid back into geothermal systems, providing an effective mode of waste-water disposal as well supplementary recharge. Cooling production boreholes is one the main disadvantages associated with reinjection, however. Tracer testing important tool for studies because tracer tests actually have a predictive power since transport orders magnitude faster than cold-front advancement around boreholes. A simple and efficient method test...