A5049056987- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Hernia repair and management
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Peripheral Neuropathies and Disorders
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Polyomavirus and related diseases
- Liver Disease and Transplantation
- Patient Safety and Medication Errors
- Eosinophilic Disorders and Syndromes
- Radiation Dose and Imaging
- Genetic and Kidney Cyst Diseases
- Ultrasound in Clinical Applications
- Abdominal vascular conditions and treatments
- Hospital Admissions and Outcomes
- Lung Cancer Diagnosis and Treatment
Medical University of South Carolina
2024-2025
Advanced ENT and Allergy
2025
Brigham and Women's Hospital
2019-2023
Harvard University
2019-2023
Pulmonary and Critical Care Associates
2022-2023
La Jolla Alcohol Research
2023
Parks Victoria
2023
Nephrologisches Zentrum Goettingen
2023
RELX Group (United States)
2023
Hamilton Health Sciences
2023
Abstract Bacterial pneumonia is a common and serious clinical entity. Alveolar epithelial cells alveolar macrophages are the first line of defense in innate immunity against bacterial pathogens. Epithelial known to release chemokines/cytokines that recruit activate phagocytic cells. However, signals sent from back lung remain largely unexplored. We found LPS, well-recognized stimulator derived gram-negative (G−) bacteria, rapidly robustly induces secretion macrophage-derived extracellular...
Rationale: In addition to rare genetic variants and the MUC5B locus, common contribute idiopathic pulmonary fibrosis (IPF) risk. The predictive power of outside locus for IPF interstitial lung abnormalities (ILAs) is unknown. Objectives: We tested value polygenic risk scores (PRSs) with without region on IPF, ILA, ILA progression. Methods: developed PRSs that included (PRS-M5B) excluded (PRS-NO-M5B) (500-kb window around rs35705950-T) using an genome-wide association study. assessed PRS...
Background The clinical impact of interstitial lung abnormalities (ILAs) on poor prognosis has been reported in many studies, but risk stratification ILA will contribute to practice. Purpose To investigate the association traction bronchiectasis/bronchiolectasis index (TBI) with mortality and outcomes individuals by using COPDGene cohort. Materials Methods This study was a secondary analysis prospectively collected data. Chest CT scans participants for were evaluated compared without from...
Although interstitial lung abnormalities (ILA), specific patterns of incidentally-detected abnormal density on computed tomography, have been associated with function and increased mortality, it is unclear if a subset incidental disease (ILD) accounts for these adverse consequences.
A current hypothesis for obstructive sleep apnea states that 1) negative airway pressure during inspiration can collapse the pharyngeal airway, and 2) neural control of airway-dilating muscles is important in preventing this collapse. To test we performed nasal mask occlusions to increase pressures eight normal five micrognathic infants. Both groups developed midinspiratory obstruction, but obstruction was more frequent infants varied some with state. The usually reopened subsequent...
Background Interstitial lung abnormalities (ILA) share many features with idiopathic pulmonary fibrosis; however, it is not known if ILA are associated decreased mean telomere length (MTL). Methods Telomere was measured quantitative PCR in the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) and Age Gene/Environment Susceptibility Reykjavik (AGES-Reykjavik) cohorts Southern blot analysis used Framingham Heart Study (FHS). Logistic linear regression were to assess...
Abstract Background Few cohorts have study populations large enough to conduct molecular analysis of ex vivo lung tissue for genomic analyses. Transcriptome imputation is a non-invasive alternative with many potential applications. We present novel transcriptome-imputation method called the Lung Gene Expression and Network Imputation Engine ( LungGENIE ) that uses principal components from blood gene-expression levels in linear regression model predict tissue-specific gene-expression....
Melanoma differentiation-associated gene 5 (MDA-5) autoimmunity has been increasingly recognized in association with interstitial lung disease (ILD), particularly the context of viral infections. While MDA-5 ILD is typically rapidly progressive high mortality, emerging evidence suggests that COVID-19 may induce a distinct, more indolent phenotype. We report two cases following infection slowly course. In Case 1, an 87-year-old woman history breast cancer, chronic obstructive pulmonary...
Many Ayurveda Scholars have been implied many theories like Raktagata Vata, Raktavrita Siragata Vata and Shleshmavrita to describe the basic of EHT, but no one has adopted theory Mishra Avarana, a concept Charaka (Ch.Chi.28/232) which might left incomplete for intellectuals (Ch.Chi.28/217) think over it in detail. In Raktapradoshaja Vikaras (Ch. Su. 24/11-16) whole symptomatology EHT e.g. Shirahashoola, Anidra, Bhrama, Akshiraga etc. are present. Hence Raktapradosha considered be involved...
Background Interstitial lung abnormalities (ILAs) are associated with increased mortality. It is unclear whether multimorbidity accounts for the mortality association or how strongly ILA relative to other common age-associated diseases. We determined of all-cause adjusted multimorbidity, compared and prevalent cardiovascular disease (CVD), diabetes mellitus, chronic kidney disease, obstructive pulmonary cancer also between these Methods measured (none, indeterminant, definite) using blinded...
The flow of oral and nasal secretions into the pharynx is a recognized source pulmonary aspiration during sleep in infants adults alike. Such probably accounts for many cases bacterial pneumonia. In infants, swallowing occurs frequently sleep, rate appears to be far greater than that sleeping adult. major mechanism whereby are transported digestive tract. Certain aspects those swallows, such as "swallow-breaths" their coordination with respiratory cycle, have been documented. A brief period...
Cerebrovascular complications are rare following viper bites. A 65-year-old man presented with loss of consciousness and developed haemiparesis a bite. Coagulation parameters were severely deranged. MRI showed acute ischaemic infarction on the left side in precentral postcentral gyrus, hemipons cerebellum. Troponin T was elevated transient bundle branch block seen. The patient had good outcome treatment Anti Snake Venom supportive therapy. Possible mechanisms discussed.