A5016319320- Photosynthetic Processes and Mechanisms
- Algal biology and biofuel production
- Antioxidant Activity and Oxidative Stress
- Pharmacogenetics and Drug Metabolism
- Chronic Myeloid Leukemia Treatments
- Extracellular vesicles in disease
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Phagocytosis and Immune Regulation
- Statistical Methods in Clinical Trials
- Toxin Mechanisms and Immunotoxins
- Cell death mechanisms and regulation
- Metal-Catalyzed Oxygenation Mechanisms
- Animal Virus Infections Studies
- PARP inhibition in cancer therapy
- Constructed Wetlands for Wastewater Treatment
- Drug Transport and Resistance Mechanisms
- Bacterial Infections and Vaccines
- Inflammatory mediators and NSAID effects
- Glycosylation and Glycoproteins Research
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
Beijing Friendship Hospital
2023-2025
Capital Medical University
2023-2025
South China University of Technology
2023-2025
Boston University
2017
East China Normal University
2017
Peking University
2016
Abstract Bacterial pneumonia is a common and serious clinical entity. Alveolar epithelial cells alveolar macrophages are the first line of defense in innate immunity against bacterial pathogens. Epithelial known to release chemokines/cytokines that recruit activate phagocytic cells. However, signals sent from back lung remain largely unexplored. We found LPS, well-recognized stimulator derived gram-negative (G−) bacteria, rapidly robustly induces secretion macrophage-derived extracellular...
Abstract Robust lung inflammation is one of the prominent features in pathogenesis acute injury (ALI). Macrophage migration and recruitment are often seen at early stage inflammatory responses to noxious stimuli. Using an acid inhalation–induced model, we explored mechanisms by which exposure initiates macrophage during development ALI. The epithelium comprises a large surface area functions as first-line defense against insults. We found that induced remarkable microvesicle (MV) release...
Abstract The aim of our study is to explore the mechanism transcription-4 (STAT4) in acute myeloid leukemia (AML). STAT4 level AML bone marrow samples/cells was analyzed using bioinformatics and quantitative real-time PCR. correlation between high expression prognosis patients analyzed. viability, apoptosis, angiogenesis cells were detected. levels STAT4, vascular endothelial growth factor A (VEGFA), apoptosis-related proteins (Bcl-2 Bax) transfected examined. upregulated AML. silencing...
Bruton's tyrosine kinase (BTK) inhibitors play a critical role in the treatment of mantle cell lymphoma (MCL). pirtobrutinib, new, highly selective, non-covalent BTK inhibitor, was approved by FDA for MCL, chronic lymphocytic leukemia (CLL), and small (SLL). In this study, we established robust reliable method quantitation pirtobrutinib rat plasma using ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Acetonitrile 0.1% formic acid served as mobile phase,...
The number of drug-drug interaction (DDI) clinical trials in China has increased rapidly recent years. aim this study was to summarize and analyze DDI over the past 10 We conducted a cross-sectional registered Chinese Center for Drug Evaluation (CDE) from September 6, 2013 December 31, 2022. All related registration information disclosed on CDE website were summarized analyzed. Although before 2017 relatively low, it markedly after 2017. average duration 85.83 ± 100.99 days 2019 107.16 98.57...
Wetlands are important sinks for mercury, and its reducing substrate favors the production of gaseous elemental mercury. In order to adapt anoxic condition, wetland plants usually have developed aerenchyma transfer oxygen from shoots roots supply their respiration. this study, a typical plant, rice, is used investigate whether can also be channel transportation rhizosphere mercury into atmosphere. addition, underlying mechanisms will evaluated. rice were separated by an air-tight chamber....
Abstract A drug–drug interaction (DDI) trial of cytochrome P450 3A (CYP3A) is a necessary part early‐phase trials drugs mainly metabolized by this enzyme, but CYP3A DDI clinical do not have standard design, especially for Chinese people. We aimed to offer specific recommendations design. This was an open, three‐cycle, self‐controlled study. Healthy subjects were given different administration strategies CYP3A4 perpetrators. In each cycle, blood samples collected before and within 24 h after...
Background: Immunothrombosis is a physiological process that constitutes an intravascular innate immune response. Abnormal immunothrombosis can lead to thrombotic disorders. With the outbreak of COVID-19, there increasing attention mechanisms and its critical role in events, growing number relevant research papers are emerging. This article employs bibliometrics discuss current status, hotspots, trends this field. Methods: Research published from January 1, 2003, May 29, 2023, were collected...
Abstract SKLB1028 is a novel multi‐target protein kinase inhibitor under investigation for the treatment of FLT3‐ITD mutated acute myeloid leukemia. Based on preclinical characterization metabolism, three drug–drug interaction clinical studies were performed to investigate effects itraconazole, rifampin (CYP3A4 and inducer, respectively), gemfibrozil (CYP2C8 inhibitor) metabolism SKLB1028. Fourteen healthy Chinese male subjects enrolled in each study. In Study 1, administered single dose...
Purpose: To evaluate the safety and pharmacokinetics of olaparib tablet test formulation (T) reference (R) in healthy Chinese male subjects. Subjects Methods: This was a single-dose, randomized-sequence, two-way crossover study including three parts: part A: exploration design lower dose (n = 14, 100 mg), B: pivotal comparative pharmacokinetic (PK) trial under fast condition 44, 150 mg) C: PK food mg). Blood samples were collected for 72 hours parameters C max , AUC 0-t, 0-∞ used to...