A5031928455- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Pain Management and Opioid Use
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Microplastics and Plastic Pollution
- Pain Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Flavonoids in Medical Research
- Statistical Methods in Clinical Trials
- Analytical Chemistry and Chromatography
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chemical Reactions and Isotopes
- Inflammasome and immune disorders
- Berberine and alkaloids research
- Biosimilars and Bioanalytical Methods
- Phosphodiesterase function and regulation
- Opioid Use Disorder Treatment
- biodegradable polymer synthesis and properties
- Click Chemistry and Applications
- Pancreatic function and diabetes
Capital Medical University
2021-2025
Beijing Friendship Hospital
2020-2025
Fudan University
2024
Southern University of Science and Technology
2023
Academy of Military Medical Sciences
2011-2021
Henan University of Traditional Chinese Medicine
2020
Weifang People's Hospital
2020
PLA 306 Hospital
2019
307th Hospital of Chinese People’s Liberation Army
2019
Anhui Medical University
2018
Abstract Baicalein is a biologically important flavonoid in extracted from the Scutellaria baicalensis Georgi, which can effectively inhibit influenza virus. This study aimed to analyze safety and pharmacokinetic (PK) characteristics of baicalein tablets healthy Chinese subjects provide more information for phase II clinical trials. In this multiple‐ascending‐dose placebo‐controlled trial, 36 were randomized receive 200, 400, 600 mg tablet or placebo once daily on day 1 10, 3 times days 4–9....
Abstract Non-alcoholic fatty liver disease is a growing health burden with limited treatment options worldwide. Herein we report randomized, double-blind, placebo-controlled, multiple-dose trial of first-in-class pan-phosphodiesterase inhibitor ZSP1601 in 36 NAFLD patients (NCT04140123). There were three cohorts. Each cohort included twelve patients, nine whom received 50 mg once daily, twice or 100 and matching placebos for 28 days. The primary outcomes the safety tolerability ZSP1601. A...
UDP‐glucuronosyltransferases (UGTs), the most important phase II drug metabolizing enzymes (DMEs), could metabolize many drugs and various endogenous substances including bilirubin, steroid hormones, thyroid bile acids fat‐soluble vitamins. Evaluation of inhibitory effects compounds on UGTs is clinically because inhibition UGT isoforms not only result in serious drug–drug interactions (DDIs), but also induce metabolic disorders substances. The aim present study was to investigate carvacrol...
UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks drug–drug interactions (DDIs), hyperbilirubinemia drug-induced liver injury. This study aimed to investigate compare the inhibitory effects icotinib erlotinib against UGT1A1, as well evaluate their potential DDI via inhibition. The results demonstrated that both are inhibitors, but effect on is weaker than erlotinib. IC50 values...
Bruton's tyrosine kinase (BTK) inhibitors play a critical role in the treatment of mantle cell lymphoma (MCL). pirtobrutinib, new, highly selective, non-covalent BTK inhibitor, was approved by FDA for MCL, chronic lymphocytic leukemia (CLL), and small (SLL). In this study, we established robust reliable method quantitation pirtobrutinib rat plasma using ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Acetonitrile 0.1% formic acid served as mobile phase,...
The number of drug-drug interaction (DDI) clinical trials in China has increased rapidly recent years. aim this study was to summarize and analyze DDI over the past 10 We conducted a cross-sectional registered Chinese Center for Drug Evaluation (CDE) from September 6, 2013 December 31, 2022. All related registration information disclosed on CDE website were summarized analyzed. Although before 2017 relatively low, it markedly after 2017. average duration 85.83 ± 100.99 days 2019 107.16 98.57...
Two phase I studies assessed the pharmacokinetics of buprenorphine, its metabolite norbuprenorphine, and naloxone following administration buprenorphine/naloxone sublingual tablets in Chinese participants. In first I, open-label, single ascending-dose (SAD) study, 82 opioid-naïve volunteers received a dose ranging from 2 mg/0.5 mg to 24 mg/6 while under naltrexone block. second multiple (MAD) 27 patients with opioid dependence withdrawal doses either 16 mg/4 or for 9 consecutive days. Serial...
Carvacrol (2-methyl-5-(1-methylethyl)-phenol), one of the main components occurring in many essential oils family Labiatae, has been widely used food, spice and pharmaceutical industries.The carvacrol glucuronidation was characterized by human liver microsomes (HLMs), intestinal (HIMs) 12 recombinant UGT (rUGT) isoforms.One metabolite identified as a mono-glucuronide liquid chromatography/mass spectrometry with HLMs, HIMs, rUGT1A3, rUGT1A6, rUGT1A7, rUGT1A9 rUGT2B7.The study chemical...
Sunitinib is a tyrosine kinase inhibitor with effective therapeutic outcomes in patients renal-cell carcinoma. The study were to analyze the association of single-nucleotide polymorphisms present cell-free DNA and pharmacokinetics sunitinib treatment-emergent adverse events Chinese carcinoma.We genotyped 8 keys SNPs 6 candidate genes. plasma concentrations N-desethyl measured using high performance liquid chromatography-tandam mass spectrometry method. Correlations between investigated by...
Thienorphine has been demonstrated to be a potent, long-acting partial opioid agonist. It is being developed as good candidate treat dependence.
Background: Immunothrombosis is a physiological process that constitutes an intravascular innate immune response. Abnormal immunothrombosis can lead to thrombotic disorders. With the outbreak of COVID-19, there increasing attention mechanisms and its critical role in events, growing number relevant research papers are emerging. This article employs bibliometrics discuss current status, hotspots, trends this field. Methods: Research published from January 1, 2003, May 29, 2023, were collected...