A5023086209- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal function and acid-base balance
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Vitamin D Research Studies
- Magnesium in Health and Disease
- Sodium Intake and Health
- Renal Transplantation Outcomes and Treatments
- Ion Transport and Channel Regulation
- Acute Kidney Injury Research
- Genetic Syndromes and Imprinting
- Electrolyte and hormonal disorders
- Cardiac Imaging and Diagnostics
- Healthcare Policy and Management
- Folate and B Vitamins Research
- Metabolomics and Mass Spectrometry Studies
- Biomedical Research and Pathophysiology
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Health disparities and outcomes
- Heart Failure Treatment and Management
University of Virginia
2020-2025
University of Virginia Health System
2023-2024
Duke University
2015-2022
Clinical Research Institute
2015-2022
Duke Medical Center
2018-2019
Pediatric Nephrology of Alabama
2018
Durham VA Medical Center
2016-2018
Duke University Hospital
2018
National Kidney Foundation
2014-2017
National Institute of Diabetes and Digestive and Kidney Diseases
2017
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) an important mechanism in individuals with CKD. Elevated levels FGF23 have been linked greater risks LVH and mortality patients CKD, but whether these represent causal effects unknown. Here, we report elevated are independently associated large, racially diverse CKD cohort. caused pathological isolated rat cardiomyocytes via FGF...
IBROBLAST GROWTH FACTOR 23 (FGF-23) is an endocrine hormone that regulates phosphorus metabolism.Circulating levels of FGF-23 increase progressively as kidney function declines, eventually reaching concentrations in patients with chronic disease are among the highest any condition commonly encountered clinical practice. 1Fibroblast growth factor appropriate physiological adaptation to maintain neutral phosphate balance and normal serum setting reduced renal capacity for excretion.Preventing...
An elevated level of fibroblast growth factor-23 (FGF-23) is the earliest abnormality mineral metabolism in CKD. High FGF-23 levels promote left ventricular hypertrophy but not coronary artery calcification. We used survival analysis to determine whether associated with greater risk adjudicated congestive heart failure (CHF) and atherosclerotic events (myocardial infarction, stroke, peripheral vascular disease) a prospective cohort 3860 participants CKD stages 2–4 (baseline estimated GFR...
Elevated fibroblast growth factor 23 (FGF23) levels, measured at a single time, are strongly associated with increased risk of mortality in patients CKD. There minimal data on serial FGF23 measurements In prospective case-cohort study the Chronic Renal Insufficiency Cohort, we two to five annual time points (mean 4.0±1.2) randomly selected subcohort 1135 participants, whom 203 died, and all remaining 390 participants who died through mid-2013. Higher was independently death...
<h3>Importance</h3> Levels of fibroblast growth factor 23 (FGF23) are elevated in chronic kidney disease (CKD) and strongly associated with left ventricular hypertrophy, heart failure, death. Whether FGF23 is an independent risk for atrial fibrillation CKD unknown. <h3>Objective</h3> To investigate the association CKD. <h3>Design, Setting, Participants</h3> Prospective cohort study 3876 individuals mild to severe who enrolled Chronic Renal Insufficiency Cohort Study between June 19, 2003,...
Identification of novel risk factors for chronic kidney disease (CKD) progression may inform mechanistic investigations and improve identification high-risk subgroups. The current study aimed to characterize CKD across levels numerous identify independent among those with without diabetes.
Hyperphosphatemia, which associates with adverse outcomes in CKD, is more common among blacks than whites for unclear reasons. Low socioeconomic status may explain this association because poverty both disproportionately affects racial and ethnic minorities promotes excess intake of relatively inexpensive processed fast foods enriched highly absorbable phosphorus additives. We performed a cross-sectional analysis race, status, serum phosphate 2879 participants the Chronic Renal Insufficiency...
CKD progresses more rapidly to ESRD among African Americans compared with Caucasians. Disordered mineral metabolism is severe CKD, which might partially explain the accelerated progression of their kidney disease. Here, using data from American Study Kidney Disease and Hypertension, we evaluated longitudinal changes in serum levels fibroblast growth factor-23 (FGF23), parathyroid hormone (PTH), phosphate, 25-hydroxyvitamin D a subset 420 participants followed for median 4 years. We also...
Studies of dialysis initiation timing have not accounted for predialysis clinical factors that could impact postdialysis outcomes. We examined the association health with in older adult patients United States and contrasted morbidity mortality outcomes among early [estimated GFR (eGFR)≥10 ml/min per 1.73 m2] versus later (eGFR<10 m2) initiation. included all from US Renal Data System who initiated between 2006 2008, were ≥67 years old, had ≥2 prior Medicare coverage (n=84,654). calculated...
Serum bicarbonate varies over time in chronic kidney disease (CKD) patients, and this variability may portend poor cardiovascular outcomes. The aim of study was to conduct a time-updated longitudinal analysis evaluate the association serum with long-term clinical outcomes: heart failure, atherosclerotic events, renal events (halving estimated glomerular filtration rate [eGFR] or end-stage disease), mortality.Serum measured annually, 3586 participants CKD, enrolled Chronic Renal Insufficiency...
Vascular calcification is common among patients undergoing dialysis and associated with mortality. Factors such as osteoprotegerin (OPG), osteopontin (OPN), bone morphogenic protein-7 (BMP-7), fetuin-A are involved in vascular calcification.OPG, OPN, BMP-7, were measured blood samples from 602 incident recruited United States centers between 1995 1998 part of the Choices for Healthy Outcomes In Caring ESRD Study. Their association all-cause cardiovascular mortality assessed using Cox...