A5070158926- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Pharmacological Effects and Toxicity Studies
- Acute Kidney Injury Research
- Central Venous Catheters and Hemodialysis
- Bipolar Disorder and Treatment
- Healthcare cost, quality, practices
- Nutritional Studies and Diet
- Poisoning and overdose treatments
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Muscle and Compartmental Disorders
- Medication Adherence and Compliance
- Potassium and Related Disorders
- Infective Endocarditis Diagnosis and Management
- Nutrition and Health in Aging
- Renin-Angiotensin System Studies
- Electrolyte and hormonal disorders
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Heart Failure Treatment and Management
- Magnesium in Health and Disease
Wayne State University
2016-2025
Children's Hospital of Philadelphia
2024
National Kidney Foundation
2023
Prognos (Switzerland)
2022
Detroit Medical Center
1998-2021
Memorial Medical Center
1998
Harper University Hospital
1987
United States Department of Veterans Affairs
1985
Cornell University
1985
North Shore University Hospital
1985
IBROBLAST GROWTH FACTOR 23 (FGF-23) is an endocrine hormone that regulates phosphorus metabolism.Circulating levels of FGF-23 increase progressively as kidney function declines, eventually reaching concentrations in patients with chronic disease are among the highest any condition commonly encountered clinical practice. 1Fibroblast growth factor appropriate physiological adaptation to maintain neutral phosphate balance and normal serum setting reduced renal capacity for excretion.Preventing...
Pulmonary hypertension (PH) is associated with poor outcomes in the dialysis and general populations, but its effect CKD unclear. We evaluated prevalence predictors of PH measures their associations long–term clinical patients nondialysis-dependent CKD. Chronic Renal Insufficiency Cohort (CRIC) Study participants who had Doppler echocardiography performed were considered for inclusion. was defined as presence estimated pulmonary artery systolic pressure (PASP) >35 mmHg and/or tricuspid...
<h3>Importance</h3> Levels of fibroblast growth factor 23 (FGF23) are elevated in chronic kidney disease (CKD) and strongly associated with left ventricular hypertrophy, heart failure, death. Whether FGF23 is an independent risk for atrial fibrillation CKD unknown. <h3>Objective</h3> To investigate the association CKD. <h3>Design, Setting, Participants</h3> Prospective cohort study 3876 individuals mild to severe who enrolled Chronic Renal Insufficiency Cohort Study between June 19, 2003,...
Identification of novel risk factors for chronic kidney disease (CKD) progression may inform mechanistic investigations and improve identification high-risk subgroups. The current study aimed to characterize CKD across levels numerous identify independent among those with without diabetes.
Anemia is an early complication of CKD that associated with increased morbidity and mortality. Prior data show associations between abnormal mineral metabolism markers decreased erythropoiesis. However, few studies have investigated elevated fibroblast growth factor 23 as a risk for the development anemia in patients CKD.We conducted prospective cohort study 3869 individuals mild to severe enrolled Chronic Renal Insufficiency Cohort Study 2003 2008 followed through 2013. We hypothesized...
In the general population, medication nonadherence contributes to poorer outcomes. However, little is known about adherence among adults with chronic kidney disease (CKD). We evaluated association of self-reported CKD progression and all-cause death in patients CKD.In this prospective observational study 3305 mild-to-moderate enrolled Chronic Renal Insufficiency Cohort (CRIC) Study, baseline was assessed by responses 3 questions categorized as high, medium, low. (50% decline eGFR or incident...
At a given estimated glomerular filtration rate (eGFR), individuals who are Black have higher rates of mortality and kidney failure with replacement therapy (KFRT) compared those non-Black. Whether the recently adopted eGFR equations without race preserve racial differences in risk KFRT at is unknown.To assess whether cystatin C document populations including non-Black participants.Retrospective individual-level data analysis 62 011 participants from 5 general population 3 chronic disease...
BACKGROUNDMetabolomic profiling in individuals with chronic kidney disease (CKD) has the potential to identify novel biomarkers and provide insight into pathogenesis.METHODSWe examined association between blood metabolites CKD progression, defined as subsequent development of end-stage renal (ESRD) or estimated glomerular filtrate rate (eGFR) halving, 1,773 participants Chronic Renal Insufficiency Cohort (CRIC) study, 962 African-American Study Kidney Disease Hypertension (AASK), 5,305...
Background: Prior studies associating acute kidney injury (AKI) with more rapid subsequent loss of function had methodological limitations, including inadequate control for differences between patients who AKI and those did not. Objective: To determine whether is independently associated trajectory among chronic disease (CKD). Design: Multicenter prospective cohort study. Setting: United States. Participants: Patients CKD (n = 3150). Measurements: Hospitalized was defined by a 50% or greater...
Previous studies in chronic disease states have demonstrated an association between lower urinary creatinine excretion (UCr) and increased mortality, a finding presumed to reflect the effect of low muscle mass on clinical outcomes. Little is known about relationship UCr other measures body composition terms ability predict outcomes interest.Using data from Chronic Renal Insufficiency Cohort (CRIC), UCr, fat free (FFM) as estimated by bioelectrical impedance analysis, (in subpopulation)...
Rationale & ObjectiveSafe analgesic choices are limited in chronic kidney disease (CKD). We conducted a comparative analysis of harm from opioids versus nonsteroidal anti-inflammatory drugs (NSAIDs) CKD.Study DesignProspective cohort study.Setting Participants3,939 patients with CKD the Chronic Renal Insufficiency Cohort (CRIC) Study.Exposures30-day use reported at annual visits.OutcomesA composite outcome 50% glomerular filtration rate reduction and failure requiring replacement therapy...
This morphologic and morphometric study of native-kidney biopsies six homozygous sickle hemoglobin (SS) nephrotics defines a distinctive glomerulopathy focal sclerosis developing in maximally hypertrophied glomeruli. In each biopsy, two patterns segmental glomerulosclerosis were observed: "collapsing" pattern an "expansive" pattern. Morphologic analysis comparing group mean glomerular (Bowman's capsular) diameters indicates that glomeruli SS are routinely markedly enlarged whether nephrotic...
To determine the association between cognition and levels of cystatin C in persons with chronic kidney disease (CKD).Prospective observational study.Chronic Renal Insufficiency Cohort Cognitive Study.Individuals a baseline cognitive assessment completed at same visit as serum measurement (N = 821; mean age 64.9, 50.6% male, 48.6% white).Levels were categorized into tertiles; function was assessed using six neuropsychological tests. Scores on these tests compared across tertiles linear...
Measured GFR (mGFR) has long been considered the gold standard measure of kidney function, but recent studies have shown that mGFR is not consistently superior to eGFR in explaining CKD-related comorbidities. The associations between longitudinal changes versus and adverse outcomes examined. We analyzed a subset 942 participants with CKD Chronic Renal Insufficiency Cohort Study who had at least two mGFRs eGFRs determined concurrently by iothalamate creatinine (eGFR cr ) or cystatin C,...
Hematuria is associated with chronic kidney disease (CKD), but has rarely been examined as a risk factor for CKD progression. We explored whether individuals hematuria had worse outcomes compared to those without in the CRIC Study. Participants were racially and ethnically diverse group of adults (21 74 years), moderate CKD. Presence (positive dipstick) from single urine sample was primary predictor. Outcomes included 50% or greater reduction eGFR baseline, ESRD, death, over median follow-up...
Significance Statement Studies of the adverse renal consequences AKI have almost exclusively focused on eGFR changes, whereas few studies examined AKI’s effects proteinuria. The authors analyzed data from two prospective cohort that assessed urine protein-to-creatinine ratio, BP, eGFR, medication use and other important covariates annually per research protocol tracked interim episodes hospitalization for AKI. They found an episode hospitalized was independently significantly associated with...