A5067350143- Dialysis and Renal Disease Management
- Hormonal and reproductive studies
- Pharmacological Effects and Toxicity Studies
- Restless Legs Syndrome Research
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Palliative Care and End-of-Life Issues
- Chronic Kidney Disease and Diabetes
- Neurological and metabolic disorders
- Contact Dermatitis and Allergies
- Sexual function and dysfunction studies
- Sexual Differentiation and Disorders
- Vitamin D Research Studies
- Thyroid Disorders and Treatments
- Bipolar Disorder and Treatment
- Patient-Provider Communication in Healthcare
- Healthcare cost, quality, practices
- Ethics in medical practice
- Cholesterol and Lipid Metabolism
- Hormonal Regulation and Hypertension
- Fatty Acid Research and Health
- Psoriasis: Treatment and Pathogenesis
- Muscle metabolism and nutrition
- Erythropoietin and Anemia Treatment
- Optimism, Hope, and Well-being
Massachusetts General Hospital
2013-2024
Harvard University
2024
University of California, San Francisco
2019
University of Pennsylvania
2014
Current approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various levels or whether deficiencies testosterone, estradiol, both account for clinical manifestations.
The appropriateness of current reference ranges for thyroid function testing in older adults has been questioned. This study aimed to determine the relationship between tests within euthyroid range and adverse outcomes not taking medication. US community-dwelling years (n = 2843) enrolled onto Cardiovascular Health Study with TSH, free T4 (FT4), total T3 concentrations range. Incidence atrial fibrillation, coronary heart disease, failure, hip fracture, dementia, all-cause death were...
Background and objectives Uremic symptoms, including fatigue, anorexia, pruritus, nausea, paresthesia, pain, are attributed to the accumulation of organic waste products normally cleared by kidneys, but whether kidney function is primary driver changes in symptom severity over time not known. The goal our study was evaluate association between eGFR uremic score patients with CKD. Design, setting, participants, measurements We identified 3685 participants CKD on dialysis prospective,...
Protein carbamylation, a post-translational protein modification primarily driven by urea, independently associates with adverse clinical outcomes in patients CKD. Biomarkers used to quantify carbamylation burden have mainly included carbamylated albumin (C-Alb) and homocitrulline (HCit, lysine). In this study, we aimed compare the prognostic utility of these two markers order facilitate comparisons existing studies employing either marker alone, inform future studies.
Abstract Context Most labs set the lower limit of normal for testosterone at 2.5th percentile values in young or age-matched men, an approach that does not consider physiologic changes associated with various concentrations. Objective To characterize dose-response relationships between gonadal steroid concentrations and measures regulated by steroids older men. Design, Participants, Intervention 177 men aged 60 to 80 were randomly assigned receive goserelin acetate plus either 0 (placebo),...
Background Pruritus is a common symptom experienced by patients with nondialysis CKD, but risk factors for incident pruritus in this patient population have not been evaluated. Methods We identified 1951 participants CKD the Chronic Renal Insufficiency Cohort Study without at baseline assessment. was assessed Kidney Disease Quality of Life-36 (KDQOL-36) instrument, and moderate-to-severe defined as response 3 or higher on Likert scale 1–5. used time-updated multivariable joint models to...
The CACNA1H gene encodes the pore-forming α1 subunit of T-type voltage-dependent calcium channel Ca V 3.2, expressed abundantly in adrenal cortex. Mutations are associated with various forms primary aldosteronism (PA), including familial hyperaldosteronism type 4 (FH4). We describe a patient refractory hypokalaemia and elevated aldosterone secretion independent renin activity. Despite absence overt hypertension this patient, laboratory evaluation was consistent diagnosis PA. Whole-exome...
Uremic toxins contributing to increased risk of death remain largely unknown. We used untargeted metabolomics identify plasma metabolites associated with mortality in patients receiving maintenance hemodialysis.