A5021658537- Parathyroid Disorders and Treatments
- Cardiac pacing and defibrillation studies
- Muscle Physiology and Disorders
- Magnesium in Health and Disease
- Fibroblast Growth Factor Research
- Tissue Engineering and Regenerative Medicine
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Genetic Syndromes and Imprinting
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Diphtheria, Corynebacterium, and Tetanus
- Cardiac electrophysiology and arrhythmias
- Extracellular vesicles in disease
- Syphilis Diagnosis and Treatment
- Cardiovascular Effects of Exercise
- Advanced MRI Techniques and Applications
- Viral Infections and Immunology Research
- Heme Oxygenase-1 and Carbon Monoxide
- Transplantation: Methods and Outcomes
- Ultrasound in Clinical Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dialysis and Renal Disease Management
- Renal function and acid-base balance
Vanderbilt University Medical Center
2022-2023
Northwestern University
2015-2023
Saint Francis Hospital
2022-2023
Ted Rogers Centre for Heart Research
2023
University Health Network
2023
National Cerebral and Cardiovascular Center
2023
St. Francis Hospital
2023
Saint Francis University
2023
Vanderbilt University
2021-2022
Cardiovascular Institute of the South
2020
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) an important mechanism in individuals with CKD. Elevated levels FGF23 have been linked greater risks LVH and mortality patients CKD, but whether these represent causal effects unknown. Here, we report elevated are independently associated large, racially diverse CKD cohort. caused pathological isolated rat cardiomyocytes via FGF...
An increased circulating level of fibroblast growth factor 23 (FGF23) is an independent risk for mortality, cardiovascular disease, and progression chronic kidney disease (CKD), but its role in transplant allograft patient survival unknown. We tested the hypothesis that FGF23 all-cause mortality loss a prospective cohort 984 stable recipients. At enrollment, estimated GFR (eGFR) was 51 ± 21 ml/min per 1.73 m(2) median C-terminal 28 RU/ml (interquartile range, 20 to 43 RU/ml). Higher levels...
Cardiac dysfunction in CKD is characterized by aberrant cardiac remodeling with hypertrophy and fibrosis. a state of severe systemic Klotho deficiency, restoration attenuates vascular calcification associated CKD. We examined the role models deficiency—genetic hypomorphism, high dietary phosphate intake, aging, Klotho-deficient mice exhibited before 12 weeks age followed In wild-type mice, induction led to cardiovascular changes not observed control mice. Notably, non-CKD fed high-phosphate...
Plasminogen activator inhibitor 1 (PAI-1) is a functional biomarker of the metabolic syndrome. Previous studies have demonstrated that PAI-1 mechanistic contributor to several elements syndrome, including obesity, hypertension and insulin resistance. Here we show also critical regulator hepatic lipid metabolism. RNA sequencing revealed directly regulates transcriptional expression numerous genes involved in mammalian homeostasis, PCSK9 FGF21. Pharmacologic or genetic reductions plasma...
Activation of fibroblast growth factor receptor (FGFR)-dependent signalling by FGF23 may contribute to the complex pathogenesis left ventricular hypertrophy (LVH) in chronic kidney disease (CKD). Pan FGFR blockade PD173074 prevented development LVH 5/6 nephrectomy rat model CKD, but its ability treat and reverse established is unknown. CKD was induced rats nephrectomy. Two weeks later, began treatment with vehicle (0.9% NaCl) or PD173074, 1 mg/kg once-daily for 3 weeks. Renal function...
Cardiac implantable electronic device (CIED) infection has a high mortality. Previous investigations showed reduced postoperative infections using skin preparation with chlorhexidine, preoperative intravenous antibiotics, and TYRX-a antibacterial envelope. The additional benefit of antibiotic pocket wash antibiotics not been systematically studied.
Viral myocarditis is a major cause of sudden cardiac death in children and young adults. Among viruses, coxsackievirus B3 (CVB3) the most common agent for myocarditis. Recently, more consideration has been given to role signaling pathways pathogenesis enteroviral myocarditis, providing new platform identifying potential therapeutic target this, so far, incurable disease. Previously, we reported on protein kinase-B/Akt CVB3 replication virus-induced cell injury. Here, report regulation Akt...
Fibroblast growth factor 23 (FGF23) is an endocrine hormone that secreted by bone and acts on the kidney parathyroid glands to regulate phosphate homeostasis. The effects of FGF23 homeostasis are mediated binding FGF receptors their coreceptor, αklotho, which abundantly expressed in glands. However, mechanisms how regulates handling proximal tubule unclear because αklotho primarily distal nephron humans rodents. purpose this study was gain additional insight into FGF23-αklotho system...
Abstract Introduction Focal impulse and rotor modulation (FIRM) ablation can be used to target nonpulmonary vein (PV) sources of atrial fibrillation (AF). No published studies have compared freedom from (FFAF) after pulmonary reisolation (PVRI) plus FIRM PVRI alone in patients with reconnected PVs undergoing repeat ablation. Methods A 3:1 matched retrospective cohort study was performed on 21 recurrent AF PV reconnection who underwent FIRM‐guided 63 treated at a single institution. All the...
A 55-year-old male was admitted to the hospital with pneumonia. During an intubation procedure, patient received application of endobronchial lidocaine (4% gel). Within 2 h intubation, developed worsening hypoxia, and investigation arterial blood gasses revealed a pH 7.21, carbon dioxide partial pressure (PaCO2) 3.3 kPa, oxygen (PaO2) 55.1 measured saturation 49%. Co-oximetry this sample returned methemoglobin level 53%. Intravenous methylthioninium chloride (1% solution at 1 mg/kg)...
Heart failure contributes to Duchenne muscular dystrophy (DMD), which arises from mutations that ablate dystrophin, rendering the plasma membrane prone disruption. Cardiomyocyte breakdown in patients with DMD yields a serum injury profile similar other types of myocardial release creatine kinase and troponin isoforms. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are highly useful but can be improved. We generated hiPSC-CMs patient subjected these cells equibiaxial...
ABSTRACT Heart failure is a major source of mortality in Duchenne muscular dystrophy (DMD). DMD arises from mutations that ablate expression the protein dystrophin, which render plasma membrane unusually fragile and prone to disruption. In patients, repeated mechanical stress leads damage cardiomyocyte loss. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offer opportunity study specific context human cell, but these models can be improved by adding physiologic stressors. We...
Amyloidosis is caused by deposition of abnormal amyloid fibrils with the feared consequence end stage organ failure. Cardiac amyloidosis (CA) an increasingly recognized antecedent cardiomyopathy. CA classified into transthyretin variants (ATTRwt – wild type and ATTRv genetic variant) a light chain variant (AL); each these can be associated unique electrophysiologic abnormalities. Pacing indications in current societal guidelines do not specify treatment options infiltrative cardiac diseases,...
Endocarditis and cardiovascular implantable electronic device (CIED) infection are rare presentations of disseminated gonococcal (DGI). We report a case endocarditis with large vegetation adherent to the tricuspid valve CIED leads. Surgical intervention was able be avoided through use transcatheter debulking extraction.
Introduction and Aims: Aberrant calcium signaling has been implicated in many scenarios of kidney disease glomerular damage.Gain function mutations TRPC6 channels can lead to alterations proper podocyte morphology the loss integrity filter leading proteinura.Additionally, increases intracellular occur under other non-genetic insults such as blood pressure elevation, bacterial infection, trauma.The protein phosphatase calcineurin is activated when cytoplasmic levels rise, our group previously...
e21086 Background: Microvesicles are subcellular entities that derived from a variety of cells and contain DNA, RNA protein. We have previously shown microvesicles isolated murine lung tissue (lung-derived microvesicles, LDMV) enter whole bone marrow (WBM) in culture WBM has consumed LDMV produce lung-specific mRNA protein up to three weeks later. wished determine the persistence these phenotypic changes long-term vitro an vivo transplant model. Methods: In study: cell-free conditioned media...
e21092 Background: We have previously shown that lung-derived microvesicles (MVs) can enter target marrow cells, resulting in increased levels of lung-specific mRNAs. Marrow which has been exposed to MVs also show production pulmonary epithelial cells after transplantation into irradiated mice. The present studies addressed the universality mRNA modulation and underlying mechanisms. Methods: see results section Results: Co-culture heart, brain, liver, lung tissue opposite murine marrow, but...
The May highlights from the Circulation family of journals span several topics in cardiovascular medicine.The results a randomized trial to reduce pocket infections are presented Circulation: Arrhythmia and Electrophysiology.Heart transplant outcomes among high-and low-risk donor recipient characteristics analyzed Heart Failure.The incidence complications COVID during pandemic reported Cardiovascular Quality Outcomes.Sex-related differences plaque composition response statin therapy explored...