A5036899952- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Inflammatory Biomarkers in Disease Prognosis
- Cystic Fibrosis Research Advances
- Obstructive Sleep Apnea Research
- Congenital Heart Disease Studies
- Atomic and Subatomic Physics Research
- Neonatal Respiratory Health Research
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Air Quality Monitoring and Forecasting
- Dermatoglyphics and Human Traits
- Cephalopods and Marine Biology
- Phonocardiography and Auscultation Techniques
- Folate and B Vitamins Research
Brigham and Women's Hospital
2019-2025
Columbia University
2010-2025
Pulmonary and Critical Care Associates
2019-2024
Harvard University
2019-2024
Columbia University Irving Medical Center
2012-2019
King's College London
2019
Royal College of Physicians
2017
Université Paris Cité
1978
<h3>Importance</h3> While air pollutants at historical levels have been associated with cardiovascular and respiratory diseases, it is not known whether exposure to contemporary pollutant concentrations progression of emphysema. <h3>Objective</h3> To assess the longitudinal association ambient ozone (O<sub>3</sub>), fine particulate matter (PM<sub>2.5</sub>), oxides nitrogen (NO<sub>x</sub>), black carbon change in percent emphysema assessed via computed tomographic (CT) imaging lung...
Rationale: Air pollution may influence sleep through airway inflammation or autonomic nervous system pathway alterations. Epidemiological studies provide evidence of relationships between chronic air exposure and apnea.Objectives: To determine whether ambient-derived is associated with obstructive apnea objective disruption.Methods: We analyzed data from a sample participants in MESA (Multi-Ethnic Study Atherosclerosis) who participated both the Sleep studies. Mean annual 5-year levels to...
Cor pulmonale (right ventricular [RV] dilation) and cor parvus (RV shrinkage) are both described in chronic obstructive pulmonary disease (COPD). The identification of emphysema as a shared risk factor suggests that additional characterization is needed to understand these widely divergent cardiac processes.
Evaluation of impaired left ventricular (LV) filling has focused on intrinsic causes LV dysfunction; however, pulmonary vascular changes may contribute to reduced and dyspnea. We hypothesized that lower total volume (TPVV) computed tomography (CT) would be associated with dyspnea decrements in end-diastolic volume, particularly among ever-smokers.The Multi-Ethnic Study Atherosclerosis recruited adults without clinical cardiovascular disease 2000-02. In 2010-12, TPVV was ascertained as the...
Intense exercise in elite athletes is associated with increased left ventricular (LV) and right (RV) mass volumes. However, the effect of physical activity on RV an older community-based population unknown.We studied association between levels adults volumes.The Multi-Ethnic Study Atherosclerosis (MESA) performed cardiac magnetic resonance imaging participants without clinical cardiovascular disease. volumes were determined from manually contoured endocardial margins. was difference...
Background The relationship between emphysema progression and long-term outcomes is unclear. Purpose To determine the at CT mortality among participants with emphysema. Materials Methods In a secondary analysis of two prospective observational studies, COPDGene (clinicaltrials.gov, NCT00608764) Evaluation Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE; clinicaltrials.gov, NCT00292552), was measured points by using volume-adjusted...
Although emphysema on computed tomography (CT) is associated with increased morbidity and mortality in patients without spirometrically defined chronic obstructive pulmonary disease, no available medications target outside of alpha-1 antitrypsin deficiency. Transforming growth factor-β endothelial dysfunction are implicated pathogenesis, angiotensin II receptor blockers (ARBs) inhibit transforming factor-β, improve function, restore airspace architecture murine models. Evidence humans is,...
Background Air pollution alters small pulmonary vessels in animal models. We hypothesised that long-term ambient air exposure would be associated with differences vascular volumes a population-based study. Methods The Multi-Ethnic Study of Atherosclerosis recruited adults six US cities. Personalised exposures to black carbon, nitrogen dioxide (NO 2 ), oxides x particulate matter 50% cut-off aerodynamic diameter <2.5 μm (PM 2.5 ) and ozone were estimated using spatiotemporal In 2010–2012,...
Thrombocytosis has been associated with COPD prevalence and increased all-cause mortality in patients acute exacerbation of (AECOPD); but whether it is morbidity stable unknown. This study aims to determine the association thrombocytosis including reported AECOPD, respiratory symptoms exercise capacity. Participants were included from two multi-center observational studies (SPIROMICS COPDGene). Cross-sectional associations (platelet count ≥350 × 109/L) AECOPD during prior year (none vs....
Particulate matter (PM) exposure may directly affect the pulmonary vasculature. Although vasculature is not easily measurable, differential associations for right ventricular (RV) and left (LV) mass provide an indirect assessment of vascular damage.We tested whether long-term to PM < 2.5 μm (PM2.5) associated with greater RV mass/end-diastolic volume ratio relative LV.The Multi-Ethnic Study Atherosclerosis performed cardiac magnetic resonance (CMR) imaging among participants 45-84 years old...
Background: Bronchiectasis in adults with chronic obstructive pulmonary disease (COPD) is associated greater mortality. However, whether suspected bronchiectasis—defined as incidental bronchiectasis on computed tomography (CT) images plus clinical manifestation—is increased mortality a history of smoking normal spirometry and preserved ratio impaired (PRISm) unknown. Objective: To determine the association between spirometry, PRISm, spirometry. Design: Prospective, observational cohort....
Abnormal lung function trajectories are associated with increased risk of chronic obstructive pulmonary disease (COPD) and premature mortality; several factors for following these have been identified. Airway under-sizing dysanapsis (small airway lumens relative to size), is an COPD. The relationship between at adverse outcomes COPD largely unexplored. We test the hypothesis that differentially affects distinct