Gabrielle Y. Liu
A5069722729- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory and Cough-Related Research
- Emergency and Acute Care Studies
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Air Quality and Health Impacts
- Frailty in Older Adults
- Respiratory Support and Mechanisms
- interferon and immune responses
- Occupational exposure and asthma
- Vasculitis and related conditions
- SARS-CoV-2 detection and testing
- Cardiovascular Effects of Exercise
- Atherosclerosis and Cardiovascular Diseases
- Advanced biosensing and bioanalysis techniques
- Pediatric health and respiratory diseases
- Injury Epidemiology and Prevention
- Cardiovascular and exercise physiology
- COVID-19 diagnosis using AI
- Pleural and Pulmonary Diseases
Northwestern University
2021-2024
University of California, Davis
2024
Pulmonary and Critical Care Associates
2023
University of California, San Francisco
2019
Rationale: Current guidelines recommend patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia receive empirical antibiotics for suspected bacterial superinfection on the basis of weak evidence. Rates ventilator-associated (VAP) in clinical trials SARS-CoV-2 are unexpectedly low. Objectives: We conducted an observational single-center study to determine prevalence and etiology at time initial intubation incidence subsequent VAP pneumonia. Methods: Bronchoscopic...
Computed tomography (CT) imaging complements spirometry and may provide insight into racial disparities in respiratory health.
Abstract Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in feasibility reproducibility CRF measurements have impeded its use for clinical decision-making. Here we link proteomic profiles to 14,145 individuals across four international cohorts with diverse ascertainment methods establish, validate characterize a score. In cohort around 22,000 UK Biobank, score was associated reduced risk all-cause...
Quantitative interstitial abnormalities (QIAs) are early measures of lung injury automatically detected on chest computed tomography scans. QIAs associated with impaired respiratory health and share features advanced diseases, but their biological underpinnings not well understood.
Current genetic discovery methods are largely restricted to profiling circulating molecules or architecture, limited in use of tissue-based molecular genetics identify pathogenic and therapeutic targets. Here, we leverage a multi-level platform integrating population-level proteomics with functional genomic analyses based on human coronary artery tissue reveal determinants disease susceptibility. Using aptamer-based (~7,000 aptamers) across ~3,000 individuals, first identified the proteome...
Introduction Visually normal areas of the lung with high attenuation on computed tomography (CT) imaging, termed CT injury, may represent injured but not yet remodelled parenchyma. This prospective cohort study examined if injury is associated future interstitial features and restrictive spirometry abnormality among participants from Coronary Artery Risk Development in Young Adults (CARDIA) study. Methods CARDIA a population-based scans obtained at two time points were assessed objectively...
Accelerated decline in lung function is associated with incident COPD, hospitalizations and death. However, identifying this trajectory longitudinal spirometry measurements challenging clinical practice.
Abstract Objectives Critical illness reduces β-lactam pharmacokinetic/pharmacodynamic (PK/PD) attainment. We sought to quantify PK/PD attainment in patients with hospital-acquired pneumonia. Methods Meropenem plasma PK data (n = 70 patients) were modelled, rates calculated for empirical and definitive targets, between-patient variability was quantified [as a coefficient of variation (CV%)]. Results Attainment 100% T>4×MIC variable both (CV% 92) directed 33%) treatment. Conclusions...