A5058729219- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Lipid metabolism and disorders
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Heavy Metal Exposure and Toxicity
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Alcohol Consumption and Health Effects
- Inflammatory mediators and NSAID effects
- Metabolism and Genetic Disorders
- Ginger and Zingiberaceae research
- Liver physiology and pathology
- Immune cells in cancer
- Liver Disease and Transplantation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pediatric Hepatobiliary Diseases and Treatments
- Endoplasmic Reticulum Stress and Disease
Ghent University Hospital
2017-2023
Ghent University
2019-2021
VIB-UGent Center for Medical Biotechnology
2017
Angiogenesis contributes to the development of nonalcoholic steatohepatitis (NASH) and promotes inflammation, fibrosis, progression hepatocellular carcinoma (HCC). Angiopoietin‐2 (Ang‐2) is a key regulator angiogenesis. We aimed investigate role Ang‐2 its potential as therapeutic target in NASH using human samples, vivo mouse models, vitro assays. Serum levels were determined 104 obese patients undergoing bariatric surgery concomitant liver biopsy. The effect Ang‐2/Tie2 receptor inhibiting...
Background and Aims: Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease for which pharmacological treatment options are currently unavailable. PSC strongly associated with colitis a disruption of the gut-liver axis, macrophages involved in pathogenesis PSC. However, how interactions specific macrophage populations contribute to incompletely understood. Approach Results: We investigated impact cholestasis on hepatic colonic microenvironment, performed...
Abstract Patients with chronic liver disease from different aetiologies show a light serum Cu isotopic composition compared to the reference population, enrichment in 63Cu isotope correlating severity of disease. However, mechanisms underlying fractionation at onset and during progression are still unclear. In this work, common bile duct ligation (CBDL) murine model was used investigate effect cholestasis-induced on composition. Wild type male female mice underwent surgical were sacrificed...
Abstract Hepatocyte death during acetaminophen (APAP) intoxication elicits a reactive inflammatory response, with hepatic recruitment of neutrophils and monocytes, which further aggravates liver injury. Neutrophil elastase (NE), secreted by activated neutrophils, carries degradative cytotoxic functions maintains proinflammatory state. We investigated NE as therapeutic target in acetaminophen-induced injury (AILI). C57BL/6 mice were administered toxic dose APAP, 2 h prior to receiving the...
High-resolution LA-ICP-MS bioimaging was shown suitable for the quantitative visualization of Cu distribution in fibrotic mouse liver tissues on a (sub-)cellular level.
Abstract Objective The occurrence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. To challenge the current incidence NAFLD, non-invasive markers that could identify patients at risk or monitor progression are an important need. Copper intake and organ copper concentrations have earlier been linked to NAFLD progression, but serum does not adequately represent state. Cu atoms occur under form two stable isotopes, 63 65 Cu, ratio both (expressed as δ in ‰) blood has shown...
Acetaminophen (APAP) intoxication is the foremost cause of drug-induced liver failure in developed countries. The only pharmacologic treatment option, N-acetylcysteine (NAC), not effective for patients who are admitted too late and/or have excessive damage, emphasizing need alternative options. APAP results hepatocyte death and release danger signals, which further contribute to injury, part by hepatic monocyte/macrophage infiltration activation. Metallothionein (MT) 1 2 important signaling...