A5102942054- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Law, Economics, and Judicial Systems
- Legal and Constitutional Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal Transplantation Outcomes and Treatments
- European Monetary and Fiscal Policies
- Global Financial Crisis and Policies
- Transplantation: Methods and Outcomes
- Judicial and Constitutional Studies
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Economic Theory and Policy
- German Economic Analysis & Policies
- Abdominal vascular conditions and treatments
- Jury Decision Making Processes
- Legal Systems and Judicial Processes
- Criminal Law and Evidence
- Hepatitis C virus research
University Hospital Frankfurt
2018-2024
Goethe University Frankfurt
1977-2024
Johannes Gutenberg University Mainz
2010-2024
University Medical Center of the Johannes Gutenberg University Mainz
2012-2024
Sana Klinikum Lichtenberg
2016-2023
University of Kassel
2015-2021
Cornell University
2008-2020
Vanderbilt University
2017-2019
Bayer (Germany)
2019
Sana Klinikum
2018
Criteria to select patients with hepatocellular carcinoma (HCC) for liver transplantation (LT) are based on tumor size and number of nodules rather than biology. The present study was undertaken assess the role transarterial chemoembolization (TACE) in selecting tumors suitable LT. Ninety-six consecutive HCC were treated by repeatedly performed TACE, 62 them exceeding Milan criteria. Patients meeting criteria immediately listed, beyond listing listed upon downstaging following successful...
We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC).In a prospective-randomized open-label international trial, 525 LTx recipients HCC initially receiving mammalian target of rapamycin inhibitor-free were randomized 4 to 6 weeks after into group on (group A: 264 patients) or incorporating sirolimus B: 261). The primary endpoint was recurrence-free survival (RFS); intention-to-treat (ITT)...
Abstract Background The potential anti-cancer effects of mammalian target rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic in the pure oncology setting, and at present, no endpoint-directed RCT has reported high-malignancy risk population immunosuppressed transplant recipients. Interestingly, since mTOR both immunosuppressive effects, they simultaneously protect against...
Aiming at avoidance of futile surgery, we have tested whether radiofrequency ablation (RFA) may be used as first-line treatment in patients with colorectal metastases (CRLM) occurring within the first year after surgery.Surgical resection is standard CRLM. Major retrospective analyses identified interval between surgery and occurrence CRLM to prognostic importance. So far, it unknown survival respective hampered if RFA treatment.According a clinical pathway, treated detected preferentially...
The aim of this study was to evaluate the survival benefit sirolimus in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) (exploratory analysis SiLVER-trial).Patients receiving LT) HCC are at a high risk tumor recurrence. Calcineurin inhibitors have shown evidence promote cancer growth, whereas mammalian target rapamycin (mTOR) like anticancer effects. In SiLVER-trial (Clinicaltrials.gov: NCT00355862), effect on recurrence after LT investigated prospective...
Complications involving the portal vein or vena cava, are rare after orthotopic liver transplantation. We report on incidence and treatment of venous complications following 1000 transplantations in 911 patients. Twenty‐six adult patients (2.7%) suffered from transplantation, whereas cava were observed only 17 (1.8%). Technical problems recurrence underlying disease (e.g. Budd–Chiari syndrome) accounted for majority alteration vessel wall splenectomy during transplantation could be...
Abstract Background Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum endogenous substrates detoxification xenobiotics chemotherapeutics. The became pharmaceutically interesting, because OCTs determinants cytotoxicity platin derivates transport activity has been shown to correlate with sensitivity tumors towards tyrosine kinase inhibitors. No data exist about relevance in hepatocellular carcinoma (HCC). Methods OCT1 ( SLC22A1...
Melatonin induces apoptosis in many different cancer cell lines, including hepatocellular carcinoma cells. However, the responsible pathways have not been clearly elucidated. A member of forkhead transcription factors' family, FoxO3a, has implicated expression proapoptotic protein Bim (a Bcl-2-interacting mediator death). In this study, we used human HepG2 liver cells as an vitro model to investigate whether melatonin treatment through regulation by factor FoxO3a. Cytotoxicity was compared...
Cholangiocellular carcinoma (CCA) is a primary hepatic malignancy derived from cholangiocytes. The prognosis for CCA patients very poor and conventional chemotherapy has been proven ineffective in improving long‑term patient survival rates. Organic cation transporters (OCTs) mediate the transport of broad spectrum endogenous substrates detoxification xenobiotics. Moreover, OCTs are considered responsible responsiveness towards platinum‑based chemotherapies. Currently, there no data available...
Pancreas transplantation is the only curative treatment option for patients with juvenile diabetes. Organ shortage and restrictive allocation criteria are main reasons increasing waitlists, leading to severe morbidity mortality. We designed a study increase donor pool extended (EDC) organs (donor age, 50-60 years; body mass index, 30-34 kg/m).Utilization of EDC required implementation new system within Eurotransplant. The was prospective, multicenter, 2-armed trial. primary endpoint pancreas...
<i>Background/Aims:</i> The use of intraoperative blood salvage autotransfusion (IBSA) during surgical approaches may contribute to tumour cell dissemination. Therefore, IBSA should be avoided in cases malignancy. However, the risks might acceptable liver transplantation (LT) for selected small hepatocellular carcinoma (HCC). <i>Methods:</i> In total, 136 recipients LT with histologically proven HCC explanted were included this analysis. With regard recurrence, 40...
Objectives. To report the outcome of patients with hepatocellular carcinoma (HCC) in non-cirrhotic liver depending on mode primary treatment and to define clinicopathological factors influencing patients' prognosis. Methods. A retrospective analysis an unselected cohort 105 was performed. Overall survival (OS) estimated by Kaplan–Meier method potentially prognostic were analyzed Cox regression models. Results. OS whole at 1, 3, 5 years 66%, 47%, 29%, respectively. Tobacco consumption, ECOG...
3591 Background: Adjuvant chemotherapy is offered to most pts with Stage III CRC, and a subset II disease deemed at high-risk for recurrence. Nevertheless, risk stratification strategies remain suboptimal. Detection of minimal residual (MRD) through ctDNA analysis has been shown identify high recurrence in but not disease. Methods: The next-generation sequencing based AVENIO Surveillance Kit (Research Use Only) was used single nucleotide variants (SNVs) tumor tissue within cohort 145 CRC...
From December 1999 to January 2002, 50 right lobe living donor liver transplantations were performed. The operations included an intraoperative cholangiography elicit variations in bile duct anatomy. biliary reconstruction was done whenever possible as end-to-end microanastomosis of the hepatic with recipient's duct. As a result early segmental branching tree, two segment ducts had be anastomosed 20 patients and three patients. In 12 patients, Roux-en-Y hepaticojejunostomy All anastomoses...
We analyze thousands of trials from a substantial fraction the nation's most populous counties. Evidence across 10 years and three major data sets suggests that: (1) juries judges award punitive damages in approximately same ratio to compensatory damages, (2) level awards has not increased, (3) juries' judges' tendencies differ bodily injury no‐bodily‐injury cases. Jury are associated with greater rate financial Judge