A5030229941- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Transplantation: Methods and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Appendicitis Diagnosis and Management
- Liver Diseases and Immunity
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Colorectal Cancer Treatments and Studies
- Pancreatic function and diabetes
- Colorectal Cancer Surgical Treatments
- Hepatitis C virus research
- Clinical Nutrition and Gastroenterology
- Abdominal vascular conditions and treatments
University Hospital Bonn
2016-2025
University of Bonn
2013-2025
Kyushu University
2013
Schiller International University
2008
Innate lymphocyte cells (ILCs), a novel family of innate immune are considered to function as key orchestrators defences at mucosal surfaces and be crucial for maintaining an intact intestinal barrier. Accordingly, first data suggest depletion ILCs involved in human immunodeficiency virus (HIV)-associated damage the mucosa subsequent microbial translocation. However, although preferentially localized surfaces, only little is known regarding distribution gastrointestinal tract. Here, we show...
In Brief Objective: To study graft function and ischemia/reperfusion injury of porcine kidneys after preservation with the new Groningen Machine Perfusion (GMP) system versus static cold storage (CS). Introduction: The increasing proportion marginal nonheart beating donors necessitates better methods to maintain adequate viability. Hypothermic machine (HMP) is a promising alternative CS. We have therefore developed tested an HMP device, which portable actively oxygenates perfusate via...
Summary Background Chemotherapy with gemcitabine and cisplatin is the current standard for patients unresectable cholangiocarcinoma. Local photodynamic therapy has also demonstrated benefit in extrahepatic Aim To evaluate of combination systemic chemotherapy advanced Methods Three hundred fifty‐three diagnosed cholangiocarcinoma between 2004 2016 were treated at University Hospital Bonn, Germany. Of these, 96 suffering from included. Patients stratified according to treatment: (36 patients),...
Metabolic and alcoholic liver injuries result in nonalcoholic (NAFLD) or (ALD) fatty disease, respectively. In particular, presence of fibrosis NAFLD ALD requires treatment, but development drugs is hampered by the lack suitable models with significant fibrosis. The carbon tetrachloride (CCl4) model does not reflect human ALD, CCl4 may serve as a accelerator addition to another injury. Ethanol drinking water (16%) Western diet (WD) were administered for 7 wk mice either alone combination...
Acute-on-chronic liver failure (ACLF) is a syndrome associated with organ and high short-term mortality. Recently, the role of surgery as precipitating event for ACLF has been characterised. However, impact preoperative transjugular intrahepatic portosystemic shunt (TIPS) placement on development in patients cirrhosis undergoing not investigated yet.A total 926 (363 563 TIPS) were screened. Forty-five TIPS (TIPS group) 1:1 propensity matched to without (no-TIPS group). The primary endpoint...
Group 1 innate lymphoid cells (ILCs) comprise a heterogeneous family of cytotoxic natural killer (NK) and ILC1s. We identify population "liver-type" ILC1s with transcriptional, phenotypic, functional features distinct from those conventional liver-resident NK as well other previously described human ILC1 subsets. LT-ILC1s are CD49a+CD94+CD200R1+, express the transcription factor T-BET, do not activating receptor NKp80 or EOMES. Similar to cells, liver-type produce IFN-γ, TNF-α, GM-CSF;...
<h3>Objective</h3> Angiotensin II (AngII) activates via angiotensin-II-type-I receptor (AT1R) Janus-kinase-2 (JAK2)/Arhgef1 pathway and subsequently RHOA/Rho-kinase (ROCK), which induces experimental probably human liver fibrosis. This study investigated the relationship of JAK2 to portal hypertension. <h3>Design</h3> The mRNA protein levels JAK2/ARHGEF1 signalling components were analysed in 49 samples correlated with clinical parameters hypertension these patients. Correspondingly,...
Few data are available regarding the clinical performance of LOCI™-based tumor marker assays. We investigated diagnostic power carcinogenic antigen, carbohydrate antigen 19-9, 15-3, 125 and alpha-fetoprotein for detection gastrointestinal (GI) cancer.We analyzed sera from 204 patients (107 with GI cancer, 73 benign diseases 24 healthy controls) using Dimension™ Vista1500 analyzer.Levels biomarkers in controls were expected ranges only slightly higher controls. Established...
Acute portal vein thrombosis is a potentially fatal condition. In symptomatic patients not responding to systemic anticoagulation, interventional procedures have emerged as an alternative surgery. This study sought retrospectively evaluate initial results of treatment acute (aPVT) using transjugular approach.Between 2014 and 2016, 11 were treated because aPVT (male: 7; female: 4; mean age: 41.06 years). All presented rapid onset symptoms without collateralization flow assessed by CT scan at...
Abstract Background & Aims CXCR % ligands play an important role in hepatic injury, inflammation and fibrosis. While CXCL 9 11 are associated with survival patients receiving transjugular intrahepatic portosystemic shunt ( TIPS ), the of 10 severe portal hypertension remains unknown. Methods A total 89 cirrhotic were analysed. protein levels measured blood at insertion 2 weeks later 24 patients. IL 8 assessed portal, hepatic, cubital vein right atrium a further 25 insertion. Furthermore,...
Pancreas transplantation is the only curative treatment option for patients with juvenile diabetes. Organ shortage and restrictive allocation criteria are main reasons increasing waitlists, leading to severe morbidity mortality. We designed a study increase donor pool extended (EDC) organs (donor age, 50-60 years; body mass index, 30-34 kg/m).Utilization of EDC required implementation new system within Eurotransplant. The was prospective, multicenter, 2-armed trial. primary endpoint pancreas...
The DRAGON 1 trial aims to assess training, implementation, safety and feasibility of combined portal- hepatic-vein embolization (PVE/HVE) accelerate future liver remnant (FLR) hypertrophy in patients with borderline resectable colorectal cancer metastases.The is a worldwide multicenter prospective single arm trial. primary endpoint composite the PVE/HVE, 90-day mortality, one year accrual monitoring each participating center. Secondary endpoints include: resection, used PVE HVE techniques,...
Delayed gastric emptying (DGE) remains the most frequent complication following pancreatoduodenectomy (PD) with published incidences as high 61%. The present study investigates impact of bowel reconstruction techniques on DGE classic PD (Whipple-Kausch procedure) pancreatogastrostomy (PG).We included 168 consecutive patients who underwent PG either Billroth II type (BII, n = 78) or Roux-en-Y (ReY, 90) between 2004 and 2015. Excluded were conventional single loop after pylorus preserving...
Late allocation of organs for transplant impairs post–liver transplantation (LT) survival. Cardiac dysfunction, especially diastolic and autonomic is frequent plays an important role in the prognosis patients with cirrhosis. However, myocardial contractility unexplored, its prognostic value controversially discussed. This study analyses assessed by speckle tracking echocardiography LT allocation. In total, 168 cirrhosis (training cohort, 111; validation cohort [VC], 57) awaiting 2 centers...
Acute‐on‐chronic liver failure (ACLF) is a syndrome with high short‐term mortality. Precipitating events, including hemorrhage and infections, contribute to ACLF development, but the role of surgery remains unknown. We investigated development in patients cirrhosis undergoing surgery. In total, 369 were included study. The clinical laboratory data collected prior on days 1‐2, 3‐8, 9‐28, at 3 12 months after Surgery type was classified as limited or extensive, well nonliver A total 39 had...
Abstract Prognosis of patients with advanced extrahepatic cholangiocarcinoma (eCCA) is poor. The current standard first-line treatment systemic chemotherapy (CT) gemcitabine and a platinum derivate. Additionally, endobiliary radiofrequency ablation (eRFA) can be applied to treat biliary obstructions. This study aimed evaluate the additional benefit scheduled regular eRFA in real-life patient cohort under CT. All irresectable eCCA treated at University Hospital Bonn between 2010 2020 were...
Human innate lymphoid cells (ILCs) are critically involved in the modulation of homeostatic and inflammatory processes various tissues. However, only little is known about composition intrahepatic ILC pool its potential role chronic liver disease. Here, we performed a detailed characterization ILCs both healthy fibrotic livers.
Near-infrared spectroscopy (NIRS) has been utilized widely in anesthesia and intensive care to monitor regional cerebral oxygen saturation (rScO2). A normal oxygenation of extracerebral tissues may overlay thereby mask desaturations, a phenomenon known as contamination. The authors investigated the effect cessation tissue perfusion on rScO2 patients with anoxic brains.
4008 Background: Radical surgical resection represents the only potentially curative treatment option for Biliary Tract Cancer (BTC) and (incidental) Gallbladder Carcinoma ((I)GBC). Nevertheless, 5-year OS is 20–40% after curatively intended data regarding pure adjuvant chemotherapy in BTCs are currently conflicting. Encouraging results of neoadjuvant/perioperative concepts other malignancies provide a rationale to use this early phase management GBC intrahepatic as well extrahepatic...
Objectives. This summary evaluates the outcomes of orthotopic liver transplantation (OLT) HIV-positive patients in Germany. Methods. Retrospective chart analysis patients, who had been liver-transplanted Germany between July 1997 and 2011. Results. 38 transplantations were performed 32 at 9 German transplant centres. The reasons for OLT end-stage disease (ESLD) and/or failure due to hepatitis C (HCV) (n = 19), B (HBV) 10), multiple viral infections 2) Budd-Chiari-Syndrome. In 2011 19/32...