A5063507505- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Fatty Acid Research and Health
- Liver physiology and pathology
- Clinical Nutrition and Gastroenterology
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Clostridium difficile and Clostridium perfringens research
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Telemedicine and Telehealth Implementation
- Abdominal vascular conditions and treatments
- Dialysis and Renal Disease Management
- Animal Virus Infections Studies
- Bacterial Infections and Vaccines
- Electrolyte and hormonal disorders
- Healthcare Technology and Patient Monitoring
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Advanced Breast Cancer Therapies
- Renal Transplantation Outcomes and Treatments
Goethe University Frankfurt
2018-2025
University Hospital Frankfurt
2018-2025
University Hospital Carl Gustav Carus
2025
Technische Universität Dresden
2025
Kliniken Essen-Mitte
2014
RWTH Aachen University
1994
Cirrhosis is known to have a high prevalence and mortality worldwide. However, in Europe, the epidemiology of cirrhosis possibly undergoing demographic changes, etiologies may changed due improvements standard care. The aim this population-based study was analyze trends course liver its complications recent years Germany.
Metabolic and alcoholic liver injuries result in nonalcoholic (NAFLD) or (ALD) fatty disease, respectively. In particular, presence of fibrosis NAFLD ALD requires treatment, but development drugs is hampered by the lack suitable models with significant fibrosis. The carbon tetrachloride (CCl4) model does not reflect human ALD, CCl4 may serve as a accelerator addition to another injury. Ethanol drinking water (16%) Western diet (WD) were administered for 7 wk mice either alone combination...
OBJECTIVES: Portal vein thrombosis seems to be dependent on local hypercoagulation and venous stasis; data regarding endothelial damage are lacking. METHODS: von Willebrad factor, a marker of damage/perturbation, factor VIII, lipopolysaccharides (LPS) were studied in the portal systemic circulation 20 cirrhotic patients undergoing transjugular intrahepatic portosystemic procedure. RESULTS: LPS higher compared with circulation, significant correlation between other 2 variables. DISCUSSION:...
Introduction Acute-on-chronic liver failure (ACLF) is characterized by high levels of systemic inflammation and parallel suppression innate immunity, whereas little known about adaptive immune immunity in ACLF. We therefore aimed to characterize the development system during progression cirrhosis Patients with compensated/stable decompensated cirrhosis, acute decompensation or ACLF were recruited from a prospective cohort study. Comprehensive immunophenotyping was performed using dimensional...
Background & Aims: Monocyte chemotactic protein 1 (MCP-1) is a potent chemoattractant for monocytes. It involved in pathogenesis of several inflammatory diseases. Hepatic MCP-1 readout macrophage activation. While inflammation major driver liver disease progression, origin and role circulating as biomarker remains unclear. Methods: CcL2 expression F4/80 staining Kupffer cells were measured correlated mouse model chronic (inhalative CCl4 7 weeks). Next, hepatic RNA levels explanted livers 39...
Journal Article Antimicrobial Resistance and Type Distribution of Streptococcus pneumoniae Isolates Causing Systemic Infections in Germany, 1992–1994 Get access R. Reinert, Reinert Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Queck, Queck Kaufhold, Kaufhold M. Kresken, Kresken Lütticken Clinical Infectious Diseases, Volume 21, Issue 6, December 1995, Pages 1398–1401, https://doi.org/10.1093/clinids/21.6.1398 Published: 01 1995 history Received: 24 April...
The efficacy of antibiotic prophylaxis to prevent spontaneous bacterial peritonitis (SBP) in patients colonized with multidrug-resistant organisms (MDROs) is unknown. We evaluated the effectiveness fluoroquinolone-based SBP an era and area frequent resistance.This a prospective observational study liver cirrhosis indication for SBP. Patients were recruited followed large German tertiary reference center comprehensive microbiological clinical monitoring performed at baseline after 30, 60, 90,...
Background: Ascites is a definitive sign of decompensated liver cirrhosis driven by portal hypertension. Although transjugular intrahepatic portosystemic shunt insertion (TIPS) indicated for therapy recurrent and refractory ascites, there no evidence‐based recommendation specific target hepatic pressure gradient (PPG) decrease. Methods: In this single‐center, retrospective trial, we investigated the decrease PPG in 341 patients undergoing TIPS or ascites until 2015. During each procedure,...
In ACLF patients, an adequate risk stratification is essential, especially for liver transplant allocation, since associated with high short-term mortality. The CLIF-C score the best prognostic model to predict outcome in patients. While lung failure generally regarded as signum malum ICU care, this study aims evaluate and quantify role of pulmonary impairment on patients.In retrospective study, 498 patients cirrhosis admission IMC/ICU were included. was defined according EASL-CLIF criteria....
Abstract Background Accurate assessment of inflammation within the intestinal wall is crucial in managing patients with Inflammatory Bowel Disease (IBD), a condition rising incidence and prevalence worldwide. Ultrasound offers an effective, non-invasive diagnostic option to diagnose monitor disease. However, traditional ultrasound highly user-dependent requires considerable experience accurately determine degree inflammation. As extension, Quantitative (QUS), analysis raw data consisting...
Background: With the COVID-19 pandemic, a rapid adoption of telemedicine became necessary. Data regarding its implementation in specialized hepatology/IBD care remain limited. This study evaluated telemedicine's effectiveness and safety during pandemic at German tertiary center explored integration into future hybrid models. Methods: In retrospective study, we analyzed 3147 patient encounters outpatient clinic Department for Gastroenterology Hepatology University Hospital Frankfurt between...
The tyrosine kinase inhibitors (TKIs) sorafenib and lenvatinib represent the first-line systemic therapy of choice for patients with hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). Under lenvatinib, HCC have shown increasingly improved overall survival in clinical studies over years. In contrast, data on LT under TKIs are scarce limited to small retrospective series. this retrospective, multicenter study, we investigated efficacy TKI influence immunosuppression LT.
Renal function assessed by creatinine is a key prognostic factor in cirrhotic patients. However, influenced several factors, rendering interpretation difficult some situations. This especially important early stages of renal dysfunction where impairment might not be accompanied an increase creatinine. Other parameters, such as cystatin C (CysC) and beta-trace protein (BTP), have been evaluated to fill this gap. none these studies considered the role patient's sex. The present study analysed...
Background Liver cirrhosis is associated with profound immunodysfunction, i.e. a parallel presence of chronic systemic inflammation and immunosuppression, which can result in acute-on-chronic liver failure (ACLF). Omega-3 fatty acids are precursors pro-resolving mediators support the resolution inflammation. Objective The aim this study was to determine plasma levels omega-3 patients ACLF. Methods Patients without ACLF were enrolled prospective cohort analyzed post-hoc for present sub-study....
Background: Hospitalized patients with end-stage liver disease are at risk of malnutrition, reduced body function, and cognitive impairment due to HE. This combination may have an impact on in-hospital falls mortality. The purpose this study was identify factors associated the analyze consequences regarding Methods: We performed a retrospective analysis hospitalized cirrhosis between 2017 2019 Department Gastroenterology University Hospital Frankfurt. Clinical data, laboratory work,...
Non-alcoholic fatty liver disease (NAFLD) is gaining in importance and linked to obesity. Especially, the development of fibrosis portal hypertension NAFLD patients requires treatment. Transgenic TGR(mREN2)27 rats overexpressing mouse renin spontaneously develop with but without This study investigated additional role obesity this model on fibrosis. Obesity was induced twelve-week old after receiving Western diet (WD) for two or four weeks. Liver assessed using standard techniques. Hepatic...
Alcoholism is one of the leading and increasingly prevalent reasons liver associated morbidity mortality worldwide. Alcoholic hepatitis (AH) constitutes a severe disease with currently no satisfying treatment options. Lipoxin A4 (LXA4), 15-lipoxygenase (ALOX15)-dependent lipid mediator involved in resolution inflammation, showed promising pre-clinical results therapy several inflammatory diseases. Since inflammation main driver progression alcoholic hepatitis, we investigated impact...
Background Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development portal vein thrombosis, frequent decompensated liver cirrhosis, is still not investigated. Methods Therefore, we used pro-thrombotic venous milieu generation by bare metal stent transjugular intrahepatic portosystemic shunt insertion, to study role prostanoids cirrhosis. Here, 89 patients receiving insertion were included study, baseline levels...
Stenosis of the biliary anastomosis predisposes liver graft recipients to bacterial cholangitis. Antibiotic therapy (AT) is performed according individual clinical judgment, but duration AT remains unclear.All with acute cholangitis Tokyo criteria grade 1 and 2 after endoscopic retrograde cholangiography (ERC) were included. Outcome patients treated short (<7 days) was compared long (>6 days). Recurrent (RC) within 28 days primary end point.In total, 30 included a median 313 (range 34-9849)...
This paper presents how patient throughput within an Emergency Department (ED) can be accurately and automatically characterized using a combination of data derived from real-time location system (RTLS) other traditional hospital IT systems such as Electronic Medical Records (EMR) Laboratory Information Systems. Such insights used by to identify bottlenecks or inefficiencies develop strategies optimize monitor flows. A descriptive, retrospective study was conducted among 1149 patients. Five...