A5077779867- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Microscopic Colitis
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Immunodeficiency and Autoimmune Disorders
- Gallbladder and Bile Duct Disorders
- Clinical Nutrition and Gastroenterology
- Vitamin D Research Studies
- Gastrointestinal motility and disorders
- Sphingolipid Metabolism and Signaling
- Pediatric Hepatobiliary Diseases and Treatments
- Dysphagia Assessment and Management
- Eosinophilic Esophagitis
- Medical Imaging and Pathology Studies
- Health and Medical Studies
- Pancreatic and Hepatic Oncology Research
- Aortic Disease and Treatment Approaches
- Organ Transplantation Techniques and Outcomes
- Peptidase Inhibition and Analysis
- Cardiac tumors and thrombi
- Nutrition and Health in Aging
- Aortic aneurysm repair treatments
- Infectious Aortic and Vascular Conditions
Goethe University Frankfurt
2017-2025
University Hospital Frankfurt
2017-2025
Fraunhofer Institute for Translational Medicine and Pharmacology
2024
Paul Ehrlich Institut
2020
Background Vitamin D is required to maintain the integrity of intestinal barrier and inhibits inflammatory signaling pathways. Objective deficiency might be involved in cirrhosis-associated systemic inflammation risk hepatic decompensation patients with liver cirrhosis. Methods Outpatients Hepatology Unit University Hospital Frankfurt advanced fibrosis cirrhosis were prospectively enrolled. 25-hydroxyvitamin (25(OH)D3) serum concentrations quantified associated markers / bacterial...
: Background and Aims: The IL-12/23 inhibitor ustekinumab (UST) opened up new treatment options for patients with Crohn's disease (CD). Due to the recent approval, real-world German data on long-term efficacy safety are lacking. This study aimed assess clinical course of CD under UST therapy identify potential predictive markers. Methods: Patients receiving in three hospitals two outpatient centers were included retrospectively analyzed. Rates short- remission response analyzed help...
Chronic hepatitis C virus (HCV) infections are causally linked with metabolic comorbidities such as insulin resistance, hepatic steatosis, and dyslipidemia. However, the clinical impact of HCV eradication achieved by direct-acting antivirals (DAAs) on glucose lipid homeostasis is still controversial. The study aimed to prospectively investigate whether antiviral therapy DAAs alters parameters.50 patients chronic who were treated screened, 49 enrolled in study. Biochemical virological data,...
Summary Background HBV DNA and quantitative (q)H B sAg levels as prognostic markers for ‐related disease are mostly validated in Asia their significance Western populations is uncertain. Aim To analyse the impact of genotype frequent mutations precore ( PC ), basal core promoter BCP ) preS on qHBsA g levels. Methods serum 465 patients with HB eAg‐negative chronic infection were correlated , preS. For a detailed analysis molecular virology, A2 genomes harbouring these analysed replication...
The factors that contribute to the development of ulcerative colitis (UC), are still not fully identified. Disruption colon barrier is one first events leading invasion bacteria and activation immune system. strongly influenced by sphingolipids. Sphingolipids impact cell–cell contacts function as second messengers. We collected blood tissue samples from UC patients healthy controls investigated sphingolipids other lipids LC-MS/MS or LC-QTOFMS. expression enzymes sphingolipid pathway were...
Background and Aims: Vitamin D has an inhibitory role in the inflammatory signaling pathways supports integrity of intestinal barrier. Due to its immunomodulatory effect, vitamin plays a chronic bowel disease (IBD) deficiency is associated with increased risk for flare. We aimed investigate what extent 25-hydroxyvitamin (25(OH)D3) level correlates activity whether cut-off value can be defined that discriminates between active remission. Methods: Patients IBD, treated at University Hospital...
Introduction: Treating biliary obstruction remains a common clinical problem. Endoscopic retrograde cholangiopancreatography (ERCP) with stent insertion the gold standard. If ERCP fails, percutaneous transhepatic drainage (PTBD) is one treatment option. Despite high success rate, early- and late onset complications occur frequently ranging from 20-70%. With this study we aimed to provide further insights on possible risk factors for PTBD-related complications. Methods: All cases PTBD...
Abstract Background: Background & Aim Mirikizumab was approved for the treatment of Ulcerative colitis (UC) in May 2023. However, real-world data especially biological-experienced patients, is scarce. We aimed to determine efficacy and persistence on mostly treatment-experienced UC patients. Methods All who were treated Inflammatory bowel disease (IBD) outpatient clinic University Hospital Frankfurt from 07/23-09/24 retrospectively analyzed. Data clinical (Simple Clinical Colitis...
Abstract Background Ceramides and sphingolipids are components of the cell membrane intestinal epithelium contribute to integrity barrier (1, 2). The expression specific sphingolipid ceramide subgroups can vary depending on inflammatory activity Inflammatory bowel diseases (IBD) may influence course disease. A distinct lipid profile was shown for ulcerative colitis compared healthy subjects different disease activity. Less data is available Crohn's (CD) (3). In this study, patients with MC...
Background: With the COVID-19 pandemic, a rapid adoption of telemedicine became necessary. Data regarding its implementation in specialized hepatology/IBD care remain limited. This study evaluated telemedicine's effectiveness and safety during pandemic at German tertiary center explored integration into future hybrid models. Methods: In retrospective study, we analyzed 3147 patient encounters outpatient clinic Department for Gastroenterology Hepatology University Hospital Frankfurt between...
Background: While systemic inflammation is recognized as playing a central role in the pathogenesis of organ failures patients with liver cirrhosis, less known about its relevance development classical hepatic decompensation. Aim: To characterize relationship between inflammation, hemodynamics, and anemia decompensation cirrhosis. Methods: This post-hoc analysis cohort study outpatients advanced fibrosis or Results: Analysis included 338 whom 51 (15%) were hospitalized due to cirrhosis...
Abstract Background Mirikizumab was approved for treating Ulcerative colitis (UC) in May 2023. However, real-world data, especially biological-experienced patients, is scarce. We aimed to determine the treatment efficacy and persistence of mostly treatment-experienced UC patients. Methods All patients treated Inflammatory Bowel Disease (IBD) outpatient clinic University Hospital Frankfurt from 07/23-11/23 were analyzed retrospectively. Data on clinical (Simple Clinical Colitis Activity Index...
Patients with head and neck cancer (HNC) are at high risk for malnutrition because of tumour localisation therapy. Prophylactic percutaneous endoscopic gastrostomy (PEG) tube placement is common practice to prevent malnutrition.To investigate the benefits prophylactic PEG HNC patients in terms influence on patients' nutritional status, utilisation rate, complications identify predictors utilisation.All consecutive who underwent insertion between 1 January 2011 31 December 2012 prior therapy...
Vedolizumab (VDZ) for subcutaneous (SC) injection was approved use in Europe 2020 and the US 2023. Promising efficacy tolerability have been proven pivotal trials. However, real-world data on SC of VDZ, especially patients with active disease, are still lacking. We aimed to determine treatment persistence drug's inflammatory bowel disease (IBD) comparison clinical remission. Patients treated IBD a tertiary care center from July December 2021 were included this study. Clinical biochemical...
To date, there is insufficient insight into inflammatory bowel disease (IBD)-associated stress, recognized disability, and contact with the social care system. We aimed to assess these parameters in IBD patients a non-IBD control group, who were invited participate an online survey developed specifically for this study (www.soscisurvey.de) help of patients. 505 166 volunteers (i.e., group) participated survey. reported significantly increased levels stress within last six months five years...
The N-terminus of the hepatitis B virus (HBV) large surface protein (LHB) differs with respect to genotypes. Compared amino terminus genotype (Gt)D, in GtA, GtB and GtC, an additional identical 11 acids (aa) are found, while GtE GtG share another similar 10 aa. Variants GtC affecting this N-terminal part associated hepatoma formation. Deletion these amino-terminal aa GtA reduces amount LHBs changes subcellular accumulation (GtA-like pattern) a dispersed distribution (GtD-like pattern). Vice...
The main disadvantage of plastic stents is the high rate stent occlusion. usual replacement interval biliary 3 months. This study aimed to investigate if a shorter 6-8 weeks impacts median premature exchange (mPER) in benign and malignant strictures.All cases with endoscopic retrograde cholangiopancreatography (ERCP) placement were retrospectively analyzed since establishing an elective every at our institution mPER was determined.A total 3979 ERCPs (1199 patients) analyzed, including 1262...
Abstract Background & Aims HBV genotype G (HBV/G) is mainly found in co‐infections with other genotypes and was identified as an independent risk factor for liver fibrosis. This study aimed to analyse the prevalence of HBV/G healthy European carriers characterize crosstalk genotypes. Methods A total 560 were tested via HBV/G‐specific PCR co‐infections. Quasispecies distribution analysed deep sequencing, clinical phenotype characterized regarding qHBsAg‐/HBV‐DNA levels frequent mutations....
Aortoesophageal fistula (AEF) is a life-threatening complication associated with endovascular aortic repair (EVAR) and occurs mostly in patients who undergo thoracic EVAR (TEVAR). To date, surgical treatment of AEF has been considered the most promising therapeutic approach. New endoscopic techniques could contribute to therapy AEF. The aim this study was analyze outcome after EVAR-associated AEF.All received diagnostics and/or for EVAR/TEVAR our center between 2010 2019 were evaluated.Seven...
Many mutation analyses of the HBV genome have been performed in search for new prognostic markers. However, Kozak sequence preceding precore was covered only infrequently these analyses. In this study, core promoter/precore region sequenced serum samples from European inactive carriers. Quadruple GCAC1809-1812TTCT found with a high prevalence 42% among all genotypes. strongly associated coexistence basal promoter (BCP) double A1762T/G1764A and lower DNA levels. vitro lead to drastically...