A5079000287- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS drug development and treatment
- Consumer behavior in food and health
- Systemic Lupus Erythematosus Research
- Pediatric Hepatobiliary Diseases and Treatments
- Nutrition and Health in Aging
- Esophageal and GI Pathology
- Diabetes and associated disorders
- Health and Medical Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- History and advancements in chemistry
- Agricultural Economics and Policy
- HIV Research and Treatment
- Respiratory Support and Mechanisms
- Environmental Science and Technology
- Pancreatitis Pathology and Treatment
- Clinical Nutrition and Gastroenterology
- interferon and immune responses
- Organ Transplantation Techniques and Outcomes
- Atomic and Subatomic Physics Research
University Hospital Frankfurt
2016-2025
Goethe University Frankfurt
2016-2025
German Center for Infection Research
2022-2024
Hospital Clínic de Barcelona
2022
Klinikum Frankfurt Höchst
1951-2020
Johannes Gutenberg University Mainz
2008-2009
München Klinik
1950
Summary Background Proton pump inhibitors ( PPI ) are widely used in patients with liver diseases. Within the last years, there have been concerns about use as they may promote infections cirrhosis. Aim As sparse data of prognostic relevance treatment, to perform a prospective study investigating relation treatment and overall survival OS cirrhotic individuals. Methods Patients cirrhosis were enrolled followed prospectively. The primary end point was . additional clinical laboratory assessed...
•Overall high effectiveness of VOX/VEL/SOF was demonstrated in an integrative analysis large real-world studies.•Significantly lower SVR rates were observed patients with GT3, advanced liver disease, HCC onset and VEL/SOF pretreatment.•RASs as well rare genotypes chimera did not impact following re-treatment.•Cirrhosis, GT3 identified independent negative predictors treatment response to VOX/VEL/SOF. Background & AimsVoxilaprevir/velpatasvir/sofosbuvir (VOX/VEL/SOF) is highly effective for...
The lymphoid tyrosine phosphatase (LYP) encoded by the protein non-receptor type 22 (PTPN22) gene is a strong inhibitor of T cells. single nucleotide polymorphism (SNP) C1858T within PTPN22 was recently associated with autoimmune thyroid disease (AITD) and I diabetes (T1D). purpose this study to examine joint association co-occurrence AITD T1D.In study, 310 white subjects were genotyped for polymorphism. population included 70 patients both T1D (AITD+T1D), only, 100 healthy controls....
Chronic hepatitis C virus (HCV) infections are causally linked with metabolic comorbidities such as insulin resistance, hepatic steatosis, and dyslipidemia. However, the clinical impact of HCV eradication achieved by direct-acting antivirals (DAAs) on glucose lipid homeostasis is still controversial. The study aimed to prospectively investigate whether antiviral therapy DAAs alters parameters.50 patients chronic who were treated screened, 49 enrolled in study. Biochemical virological data,...
Introduction. Infectious gastroenteritis is a common reason for consulting physician. Although most cases of gastrointestinal illness are self-limiting, the identification etiologic pathogen by stool specimen analysis important in more severe and epidemiological reasons. Due to broad range causative pathogens, conventional examination labour-intensive usually requires different diagnostic methods. Multiplex PCR tests [e.g. BioFire Gastrointestinal (GI) Panel] allow rapid detecting up 22...
Background & AimsThrombopoietin receptor agonists are a new class of compounds licenced for the treatment immune thrombocytopenic purpura. They currently being studied patients with thrombopenia in advanced liver disease or under therapy hepatitis C. There indications that risk development portal vein thrombosis cirrhosis might be increased thrombopoietin agonists. We report case patient Child B concurrent purpura developed agonist romiplostim.MethodsA 50-year-old woman C virus associated...
Summary Soluble CD163 (sCD163), a marker for macrophage activation, was found to be associated with the severity of liver cirrhosis. The aim current study investigate whether serum sCD163 levels correlate inflammation and fibrosis in patients chronic hepatitis B virus (HBV) infection. In retrospective cohort study, were assessed by ELISA together clinical laboratory data 186 HBV infection 15 healthy controls. relation between parameters necroinflammation analysed. Additionally, quantified...
<b><i>Background and Aims:</i></b> The aim of the study was to evaluate risk hepatocellular carcinoma (HCC) development after treatment with direct-acting antivirals (DAAs) compare HCC occurrence in these patients that among treated interferon (IFN)-based therapies. <b><i>Methods:</i></b> We analyzed a large cohort chronic hepatitis C virus for onset new DAA treatment. A historical IFN-treated investigated comparison....
Introduction: Treating biliary obstruction remains a common clinical problem. Endoscopic retrograde cholangiopancreatography (ERCP) with stent insertion the gold standard. If ERCP fails, percutaneous transhepatic drainage (PTBD) is one treatment option. Despite high success rate, early- and late onset complications occur frequently ranging from 20-70%. With this study we aimed to provide further insights on possible risk factors for PTBD-related complications. Methods: All cases PTBD...
Background: With the COVID-19 pandemic, a rapid adoption of telemedicine became necessary. Data regarding its implementation in specialized hepatology/IBD care remain limited. This study evaluated telemedicine's effectiveness and safety during pandemic at German tertiary center explored integration into future hybrid models. Methods: In retrospective study, we analyzed 3147 patient encounters outpatient clinic Department for Gastroenterology Hepatology University Hospital Frankfurt between...
Recent data highlighted the association of macrophage activation marker CD163 with histological inflammation and fibrosis in chronic hepatitis C virus (HCV) infection. The aim this study was to investigate influence successful antiviral treatment IL28B genotypes on reflected by levels HCV infected patients. In a retrospective cohort study, serum sCD163 were correlated results liver histopathology, genotyping clinical parameters 329 patients infection, 15 healthy controls 161 who achieved...
Autoimmune thyroid diseases (AITDs) frequently occur together with other endocrine autoimmune conditions, denominated as polyglandular autoimmunity (PGA). The cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene was recently associated AITD and PGA, the CTLA-4 protein is a strong inhibitor of T-cells. tumor necrosis factor alpha (TNF-α) proinflammatory cytokine. This study aimed to analyze association CT60 TNF-α -863 polymorphisms PGA. Homogeneous groups 70 patients AITD, type 1 diabetes (T1D),...
Chronic hepatitis C virus (HCV) infection is a leading cause for orthotopic liver transplantation (OLT) in the U.S. We investigated characteristics of HCV-infected patients registered OLT, and explored factors associated with mortality. Data were obtained from United Network Organ Sharing Procurement Transplantation network (UNOS/OPTN) registry. Analyses included 41,157 HCV-mono-infected ≥18 years age listed cadaveric OLT between February 2002 June 2014. Characteristics pre- post-transplant...
Hepatitis C virus (HCV) substantially affects lipid metabolism, and remodeling of sphingolipids appears to be essential for HCV persistence in vitro. The aim the current study is evaluation serum sphingolipid variations during acute infection. We enrolled prospectively 60 consecutive patients with infection, most them already infected human immunodeficiency (HIV), was collected at time diagnosis longitudinally over a six-month period until initiation antiviral therapy or confirmed...
BackgroundData on the prevalence and characteristics of so called rare HCV genotypes (GT) in larger cohorts is limited. This study investigates frequency GT resistance-associated substitutions efficacy retreatment a European cohort.MethodsA total 129 patients with GT1-6 were included from resistance database. NS3, NS5A NS5B sequenced clinical parameters efficacies collected retrospectively.ResultsOverall 1.5% (69/4656) DAA-naïve 4.4% (60/1376) DAA-failure infected GT. While almost equally...
Inhibitors against the NS3-4A protease of hepatitis C virus (HCV) have proven to be useful drugs in treatment HCV infection. Although variants been identified with mutations that confer resistance these inhibitors, do not restore replicative fitness and no secondary rescue found. To gain insight into molecular mechanisms underlying lack compensation, we screened known infectious cell culture different genomic backgrounds. We observed Q41R mutation efficiently rescues for containing at...
In patients with advanced liver cirrhosis due to chronic hepatitis C virus (HCV) infection antiviral therapy peginterferon and ribavirin is feasible in selected cases only potentially life-threatening side effects. However, predictive factors associated hepatic decompensation during are poorly defined.In a retrospective cohort study, 68 HCV-associated (mean MELD score 9.18 ± 2.72) were treated ribavirin. Clinical events indicating (onset of ascites, encephalopathy, upper gastrointestinal...