A5078262925- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Neurological Complications and Syndromes
- Adipose Tissue and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal and Vascular Pathologies
- Pregnancy and Medication Impact
- Pharmacological Effects and Toxicity Studies
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- Immune Response and Inflammation
- Gallbladder and Bile Duct Disorders
- Cardiac Ischemia and Reperfusion
- Pancreatic and Hepatic Oncology Research
- Medication Adherence and Compliance
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Palliative Care and End-of-Life Issues
- Monoclonal and Polyclonal Antibodies Research
University Hospitals of Cleveland
2017-2025
Case Western Reserve University
2017-2024
University School
2017-2024
Temple University Hospital
2023-2024
Temple University Health System
2024
WinnMed
2024
Temple University
1988-2024
Mayo Clinic
2024
Yale University
2023
University of Minnesota
2023
Uncoupling protein 2 (UCP2) uncouples respiration from oxidative phosphorylation and may contribute to obesity through effects on energy metabolism. Because basal metabolic rate is decreased in obesity, UCP2 expression predicted be reduced. Paradoxically, hepatic of mRNA increased genetically obese (ob/ob) mice. In situ hybridization immunohistochemical analysis ob/ob livers demonstrate that are hepatocytes, which do not express lean Mitochondria isolated exhibit an H+ leak partially...
In a prospective, multicenter, open-label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC Elimination) (ii) reduced-exposure (EVR+Reduced TAC) or (iii) standard-exposure Control). Randomization TAC Elimination was terminated prematurely due higher rate of treated biopsy-proven acute rejection (tBPAR). EVR+Reduced noninferior Control for the primary efficacy endpoint (tBPAR, graft loss death 12 months...
Donor-derived cell-free DNA (dd-cfDNA) is an emerging noninvasive biomarker that has the potential to detect allograft injury. The capacity of dd-cfDNA kidney rejection and its added clinical value beyond standard care patient monitoring unclear. We enrolled 2,882 recipients from 14 transplantation centers in Europe United States observational population-based study. primary analysis included 1,134 patients. levels strongly correlated with rejection, including antibody-mediated (P < 0.0001),...
Background: Mobile phone based programs for kidney transplant recipients are promising tools improving long-term graft outcomes and better managing comorbidities (eg, hypertension, diabetes). These provide an easy to use self-management framework allowing optimal medication adherence that is guided by the patients' physiological data. This technology also relatively inexpensive, has intuitive interface, provides capability real-time personalized feedback help motivate patient self-efficacy....
Abstract A murine heterotopic, nonvascularized cardiac allograft model was used to examine the effects of immunosuppressive cytokine, viral IL-10 (vIL-10), delivered by gene transfer on graft rejection. Retroviral-mediated and expression vIL-10 significantly prolonged survival, without conventional systemic immunosuppression, from 12.1 +/- 0.8 days 39.4 2.5 (p &lt; 0.0001). The effect specific, dose dependent, restricted site transplantation. PCR analysis demonstrated specific...
In a 24-month prospective, randomized, multicenter, open-label study, de novo liver transplant patients were randomized at 30 days to everolimus (EVR) + Reduced tacrolimus (TAC; n = 245), TAC Control (n 243) or Elimination 231). Randomization was stopped prematurely due significantly higher rate of treated biopsy-proven acute rejection (tBPAR). The incidence the primary efficacy endpoint, composite failure tBPAR, graft loss death postrandomization similar with EVR (10.3%) (12.5%) month 24...
Obesity-induced endoplasmic reticulum (ER) stress causes chronic inflammation in adipose tissue and steatosis the liver, eventually leads to insulin resistance type 2 diabetes (T2D). The goal of this study was understand mechanisms by which administration bilirubin, a powerful antioxidant, reduces hyperglycemia ameliorates obesity leptin-receptor-deficient (db/db) diet-induced obese (DIO) mouse models. db/db or DIO mice were injected with bilirubin vehicle ip. Blood glucose body weight...
Background and Aims Coronavirus disease 2019 (COVID‐19) is associated with liver injury, but the prevalence patterns of injury in transplantation (LT) recipients COVID‐19 are open for study. Approach Results We conducted a multicenter study United States 112 adult LT COVID‐19. Median age was 61 years (interquartile range, 20), 54.5% (n = 61) were male, 39.3% 44) Hispanic. Mortality rate 22.3% 25); 72.3% 81) hospitalized 26.8% 30) admitted to intensive care unit (ICU). Analysis peak values...
Laparoscopic live donor nephrectomy offers advantages to the in terms of decreased pain and shorter recuperation. Heretofore no detailed analysis recipient laparoscopically procured kidneys has been performed. The purpose this study was determine whether laparoscopic had any deleterious effect on recipient.A retrospective review conducted all renal transplantations performed from January 1995 through April 1998. control group received via a standard flank approach (Open). Rejection diagnosed...
The use of increased dosages glucocorticoids during periods physiologic stress in allograft recipients represents a clinical dilemma that the short-term exogenous therapy required may significantly impair wound healing and immunocompetence. To investigate whether "stress steroids" are actually necessary, prospective study was conducted 40 renal admitted with significant stress. Stress categories included sepsis, metabolic abnormalities, surgery. These patients received only their baseline...
Milk thistle (<i>Silybum marianum</i>) extracts, one of the most widely used dietary supplements, contain a mixture six major flavonolignans (silybin A, silybin B, isosilybin silychristin, and silydianin) other components. However, pharmacokinetics free individual have been only partially investigated in humans. Furthermore, antioxidant effects extract, which may underlie basis many therapeutic effects, not thoroughly assessed. The present study evaluated healthy volunteers receiving single...
Steatohepatitis occurs in up to 20% of patients with fatty liver disease and leads its primary outcomes, including fibrosis, cirrhosis, increased risk hepatocellular carcinoma. Mechanisms that mediate this inflammation are major interest. We previously showed overload saturated acids, such as which metabolic syndrome, induced sphingosine kinase 1 (SphK1), an enzyme generates sphingosine-1-phosphate (S1P). While data suggest beneficial roles for S1P some contexts, we hypothesized it may...
This article is a review of the salient points and future prospective based on 2014 Organ Procurement Transplantation Network (OPTN)/Scientific Registry Transplant Recipients (SRTR) liver donation transplantation data report recently published by American Journal Transplantation. Emphasis our commentary interpretation placed relating to waitlist dynamics, organ utilization rates, impact recent advances in treatment hepatitis C, increases end-stage renal disease among transplant candidates....
Although disruption of mitochondrial homeostasis and biogenesis (MB) is a widely accepted pathophysiologic feature sepsis-induced acute kidney injury (AKI), the molecular mechanisms responsible for this phenomenon are unknown. In study, we examined signaling pathways suppression MB in mouse model lipopolysaccharide (LPS)-induced AKI. Downregulation peroxisome proliferator-activated receptor <i>γ</i> coactivator-1<i>α</i> (PGC-1<i>α</i>), master regulator MB, was noted at mRNA level 3 hours...
Green tea extract is a widely used dietary supplement. The objective of this study was to assess the influence decaffeinated green (DGT; <i>Camellia sinensis</i>) on activity drug-metabolizing enzymes cytochrome P-450 2D6 and 3A4. Probe drugs dextromethorphan (30 mg, CYP2D6 activity) alprazolam (ALPZ; 2 CYP3A4 were administered orally healthy volunteers (<i>n</i> = 11) at baseline, again after treatment with four DGT capsules/day for 14 days. Each capsule contained 211 ± 25 mg catechins...
Standardized extracts from the Ginkgo biloba tree are purported to exert positive neurocognitive effects and may also be useful in treatment of a variety vascular other disorders. This dietary supplement is among most commonly used herbal preparations world. The objective this study was assess normal volunteers (n = 12) influence standardized (GB) on activity cytochrome P-450 (CYP) 2D6 3A4 phenotyped as CYP2D6 extensive metabolizers. Probe substrates dextromethorphan (CYP2D6 activity)...
Hepatic steatosis increases the extent of cellular injury incurred during ischemia/reperfusion (I/R) injury. (-)-Epigallocatechin gallate (EGCG), major flavonoid component green tea (camellia sinensis) is a potent antioxidant that inhibits fatty acid synthase (FAS) in vitro. We investigated effects EGCG on hepatic and markers damage at baseline after I/R ob/ob mice. Animals were pretreated with 85 mg/kg via intraperitoneal (ip) injection for 2 days or oral consumption drinking water 5 before...