A5110165808- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Renal and Vascular Pathologies
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Hepatocellular Carcinoma Treatment and Prognosis
- Polyomavirus and related diseases
- Cannabis and Cannabinoid Research
- Antifungal resistance and susceptibility
- T-cell and B-cell Immunology
- Fungal Infections and Studies
- Liver Diseases and Immunity
- Viral-associated cancers and disorders
- Nitric Oxide and Endothelin Effects
- Blood donation and transfusion practices
- Hematopoietic Stem Cell Transplantation
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Advanced Glycation End Products research
- Endoplasmic Reticulum Stress and Disease
- Veterinary medicine and infectious diseases
- Neuroendocrine Tumor Research Advances
Loma Linda University
2012-2025
Loma Linda University Medical Center
2012-2021
Miami Transplant Institute
2018
Duquesne University
2016
University of Pittsburgh
1998-2012
H.C. Starck (Germany)
2012
UPMC Health System
2012
UPMC Montefiore
2010
UPMC Hillman Cancer Center
2010
University of Pittsburgh Medical Center
2004-2008
We reviewed the cases of patients with cirrhosis, including liver transplant candidates, at our institution in last 3 years (n = 5) and those individually described literature 28), to assess unique characteristics outcome cryptococcosis these patients. Sixty-four percent (21/33) had no other recognized immunosuppression. Peritonitis (in 45%, 15/33 patients) modest pleocytosis ascitic fluid, was most common presenting feature. Median time detection Cryptococcus fluid cultures 6 days. Overall...
Abstract: Rabbit anti‐thymocyte globulin (ATG) and alemtuzumab have been used for induction or preconditioning the treatment of acute rejection in organ transplant recipients many centers. Such regimens may lead to a substantial decline CD4 lymphocyte count levels seen other population groups at high risk cryptococcosis. In view this, we examined impact such therapy on cumulative incidence cryptococcosis among liver kidney recipients. A total 834 727 transplants were performed during study...
To assess the presence of Helicobacter DNA in gastric mucosa Thoroughbred horses.Squamous and glandular samples were collected from 20 Thoroughbreds. None these horses had shown any clinical symptoms gastrointestinal disease. Necropsy tissues analysed using histopathological techniques a genus-specific PCR assay followed by sequencing amplicons. Seven diagnosed with ulceration, five gastritis six both pathologies. Only two healthy mucosa. Helicobacter-like was detected out seven ulcers,...
Context-Little is known about patients' contribution to health outcomes after liver transplantation.Yet, in other transplant recipients, nonadherent behavior directly related the leading causes of morbidity and mortality recipients.Objective-To examine patient environmental factors relation all aspects adherence posttransplantation regimen first 6 months transplantation.Design-A descriptive analysis individual at transplantation.Participants, Setting-One hundred fifty-two adult recipients...
Calcineurin-inhibiting immunosuppressive medications are the mainstay of posttransplant immunosuppression. Although these highly beneficial drugs critical for survival, significant numbers transplant recipients experience side effects, some requiring a switch to different regimen. Neurotoxicity is one most debilitating effects because its impact on mental status and cognition. As our center uses tacrolimus as initial immunosuppressant all liver (LTX) recipients, we were interested in those...
Clinical core needle biopsies present challenges for transcriptomic analysis due to limited tissue volume. In this study, we determined the feasibility of using spatial transcriptomics evaluate rejection on formalin-fixed paraffin-embedded (FFPE) from human kidney allografts. We demonstrated that non-rejection, active antibody mediated (AMR), acute cell (TCMR) and chronic AMR have distinct signatures. Subclusters monocytes/macrophages with high Fc gamma receptor IIIA (FCGR3A) expression were...
Posttransplant lymphoproliferative disorder (PTLD) is a well-established complication of immunosuppression. The involvement the gastrointestinal (GI) tract occurs in 25% all cases PTLD. Fortunately, surgical intervention seldom required. We report our experience treatment complicated GI-PTLD after liver transplantation (LTx).A retrospective analysis 5677 adult patients who underwent LTx between 1983 and 2009 was conducted.Thirty-six presented with GI-PTLD. Sixteen complications associated...
This study determines whether the recipient and donor characteristics that influence cytomegalovirus (CMV) infection rate after liver transplantation have changed.The may affect of CMV were assessed in 232 transplant recipients at our institution during a 14-year period (1989-2003).Since 1989, age (P=0.0001) donors has increased significantly. Pretransplant seropositivity decreased significantly (P=0.0001, 86.4% [1989-1992] to 53.7% [2000-2003]), whereas remained unchanged (P>0.20). As...
The use of marijuana in the USA has been steadily increasing over last 10 years. This study is first to investigate effect by live kidney donors upon outcomes both and recipients.
Abstract The purpose of this study is to compare the outcome pediatric recipients kidneys procured using a hand‐assisted laparoscopic ( HALDN group) an open technique ODN group). Twenty‐eight patients ≤18 yr old were compared with 17 serum creatinine for and groups at discharge 0.93 ± 0.48 0.94 0.54 mg/ dL (p = 0.917), respectively. six 12 months was 1.01 0.44 1.11 0.55, 1.04 0.52 1.14 0.46 0.516, p 0.554), eGFR 108.66 37.23 106.1 50.55 mL/min/1.73 m 2 0.845), 97.77 28.25 81.73 27.46, 94.56...
Introduction: Volume of renal parenchymal loss is known to affect postoperative function after partial nephrectomy (PN). We utilize a novel comparison using donor (DN) patients demonstrate the primary effect volume plays on following PN. Materials and Methods: Records 250 living 118 PN were retrospectively reviewed. Baseline characteristics preoperative estimated glomerular filtration rate (eGFR)s recorded. Percent changes in eGFR incidences surgically induced chronic kidney disease (CKD-S)...
Coexisting coronary artery disease (CAD), end-stage liver (ESLD), renal failure, and hypercoagulable state poses a formidable clinical challenge. Here, we discuss the first known case of patient with antiphospholipid syndrome (APLS), ESLD complicated by hepatorenal (HRS), severe CAD who successfully underwent combined bypass grafting (CABG) simultaneous liver/kidney (SLK) transplant.
You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation Surgery II1 Apr 2017MP30-08 DOES MARIJUANA INTAKE AFFECT OUTCOMES IN LIVING RENAL DONORS AND THEIR RECIPIENTS? David Ruckle, Mohamed Keheila, Benjamin West, Braden Mattison, Jerry Thomas, Samuel Abourbih, Michael De Vera, Arputharaj Kore, Pedro Baron, and D. Duane Baldwin RuckleDavid Ruckle More articles by this author , KeheilaMohamed Keheila WestBenjamin West MattisonBraden Mattison ThomasJerry...
123 Nitric oxide (NO) is a potent immunomodulator which has diverse roles during infection, inflammation, and solid organ transplant rejection. Previously, we have shown that combination of cytokines stimulate human inducible NO synthase (iNOS) expression, however, almost nothing known about the specific cytokine-activated nuclear factors control iNOS gene transcription. To determine molecular mechanisms transcription regulating expression gene, cloned sequenced 7.2 kilobases (kb) gene's...
The purpose of this study is to compare the diagnostic performance Sassone scoring system, IOTA LR1 and LR2 in differentiating benign from malignant ovarian masses. This was a retrospective cohort single-centre 54 women who presented with an adnexal mass at time ultrasound. ultrasound images videos were examined classified using logistic regression model 1 2; individually by expert examiner, fellow resident. findings then compared histological outcome lesion. Sixty masses included, which 12%...