A5100724524- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Colorectal Cancer Treatments and Studies
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Surgical Treatments
- Immune cells in cancer
- Hepatitis C virus research
- MicroRNA in disease regulation
- Gallbladder and Bile Duct Disorders
- COVID-19 and healthcare impacts
- Pediatric Hepatobiliary Diseases and Treatments
- Substance Abuse Treatment and Outcomes
- Hepatitis B Virus Studies
- Pharmaceutical Practices and Patient Outcomes
- Cancer, Lipids, and Metabolism
- Neonatal Health and Biochemistry
- Surgical Simulation and Training
- Drug-Induced Hepatotoxicity and Protection
- Radiomics and Machine Learning in Medical Imaging
University of California, San Francisco
2021-2025
University of Notre Dame
2025
University of California San Francisco Medical Center
2024
Promega (United States)
2024
Peter MacCallum Cancer Centre
2022
Brigham and Women's Hospital
2020-2021
Harvard University
2020-2021
Smith-Kettlewell Eye Research Institute
2020
Massachusetts Eye and Ear Infirmary
2020
University of Oklahoma Health Sciences Center
2020
Large language models (LLMs) hold tremendous potential for accelerating clinical research and augmenting care. One of the most promising LLM use cases is natural processing (NLP) extraction elements from unstructured text, which LLMs may be superior to existing NLP software packages.1Singhal K. et al.Nature. 2023; 620: 172-180Crossref PubMed Scopus (188) Google Scholar,2Bhattarai al.bioRxiv.[Preprint, September 29. https://doi.org/10.1101/2023.09.27.559788Crossref (0) Scholar Due its...
552 Background: HIMALAYA showed that D+T and D are effective options for unresectable hepatocellular carcinoma (uHCC). However, data on outcomes according to the adherence inclusion criteria in routine clinical practice lacking. Methods: In context of a prospectively maintained database including 1293 patients (pts) with uHCC treated immunotherapy, we analysed pts or across 8 centres USA, Asia Europe. Pts who met >1 key exclusion criterion (prior systemic therapy, Child-Pugh class B-C,...
Abstract Background LIV-1, a transmembrane protein and downstream target of STAT3, is highly expressed in breast cancer cells. It associated with lymph node involvement metastatic progression. SGN-LIV1A an anti-LIV-1 antibody conjugated via protease-cleavable linker to monomethyl auristatin E (MMAE). Upon binding cell-surface internalized releases MMAE, which disrupts microtubulin induces apoptosis. Methods This ongoing, phase 1 study evaluates safety, tolerability, pharmacokinetics,...
Abstract Background and Aims Consensus guidelines recommend high‐dose corticosteroids (1–2 mg/kg/day methylprednisolone equivalents) for treating grade ≥3 immune checkpoint inhibitor (ICI) hepatitis. We examined the effect of corticosteroid dosing on time to alanine aminotransferase (ALT) normalization, need additional immunosuppression, steroid‐related complications. Approach Results conducted a retrospective cohort study 215 ICI‐treated patients from 2010 2020 who developed (ALT > 200...
Large language models (LLMs) have proven useful for extracting data from publicly available sources, but their uses in clinical settings and with are unknown.
The chick chorioallantoic membrane (CAM) begins to develop by day 7 after fertilization and matures 12. CAM is naturally immunodeficient highly vascularized, making it an ideal system for tumor implantation. Furthermore, the contains extracellular matrix proteins such as fibronectin, laminin, collagen, integrin alpha(v)beta3, MMP-2, attractive model study invasion metastasis. Scientists have long taken advantage of physiology using a angiogenesis. More recently, assay has been modified work...
Background In the current study, authors assessed risks and outcomes of immune checkpoint inhibitor (ICI) rechallenge in patients with resolved grade 3 to 4 ICI hepatitis because guidelines recommend permanent discontinuation these patients. Methods The performed a retrospective cohort study from 2010 through 2019 melanoma who were treated ≥1 ICIs recovered hepatitis. primary outcome was recurrence secondary development any immune‐related adverse event (irAE) requiring rechallenge. Best...
Chemoresistance cells have features similar to cancer stem cells. Elimination of these is an effective therapeutic strategy clinically combat chemoresistance non-small cell lung (NSCLC). Here, we demonstrate that Doublecortin-like kinase1 (DCLK1) the key developing and associated stemness in NSCLC. DCLK1 highly expressed human adenocarcinoma strongly correlated with stemness. Silencing inhibits NSCLC primary secondary spheroid formation, which prerequisite feature tumor inhibition reduced...
Summary Background Immune checkpoint inhibitors (ICIs) are effective oncologic agents which frequently cause immune‐related adverse events (irAEs) can impact multiple organ systems. Onco‐Gastroenterology is a novel and emerging subspecialty within gastroenterology focused on cancer treatment‐related complications. Gastroenterologists must be prepared to identify manage diverse immune‐mediated toxicities including enterocolitis, hepatitis, pancreatitis other ICI‐induced toxicities. Aim To...
The utility of liver biopsy in diagnosis
540 Background: Hepatocellular carcinoma (HCC) is a cancer with poor prognosis and rising incidence. The combination of atezolizumab plus bevacizumab (A+B) prolongs survival as 1 st line therapy in advanced HCC (aHCC) but confers rare risk serious bleeding. brain metastases (BM) have high hemorrhage rates contraindicate the A+B regimen. Alternative immunotherapies also prolong without increased bleeding risk. We conducted retrospective review large, diverse, center registry to estimate...
Abstract Next-generation androgen receptor (AR) antagonist, like enzalutamide (Enz) has revolutionized the treatment of castration-resistant prostate cancer (CRPC), lethal form disease, by effectively suppressing axis. However, resistance to Enz eventually develops in nearly all patients. Recent studies indicate that increased glucocorticoid (GR) expression contributes resistance. Our prior work models and patient tissues suggests decreases 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2,...
Background: It is unknown how frailty evolves over time in patients with hepatocellular carcinoma (HCC) who are treated locoregional therapies (LRTs). Methods: We conducted a retrospective study of LRT-treated HCC Liver Frailty Index (LFI) assessments. Linear mixed effects modeling was used to assess the impact (modeled linearly per month) and other variables on LFI. Results: Of 201 enrolled, median baseline LFI 3.54. did not change significantly from entry (p=0.93). Conclusions: In our...
Rituximab is a monoclonal anti-CD20 antibody that standard of care for treatment B-cell non-Hodgkin lymphoma (NHL). The purpose this study was to quantify the incidence rituximab (R)-related interstitial pneumonitis (IP) in patients with NHL receiving immunochemotherapy. All who received cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), (CVP), R-CHOP or R-CVP Princess Margaret Hospital between June 1998 August 2009 were retrospectively reviewed. We compared cohorts did not...
Preoperative risk stratification is used to derive an optimal treatment plan for patients requiring cancer surgery. Patients with reversible factors are candidates prehabilitation programmes. This pilot study explores the impact of preoperative covariates comorbid disease (Charlson Co-morbidity Index), serum biomarkers, and traditional cardiopulmonary exercise testing (CPET)-derived parameters functional capacity on postoperative outcomes after major colorectal surgery.Consecutive who...
BACKGROUND: Serum bilirubin is inversely associated with cardiovascular risk. Atazanavir, an HIV protease inhibitor that competitively inhibits conjugation, provides a unique opportunity to examine whether selectively increasing cardioprotective. We sought determine patients receiving atazanavir manifest reduced risk of disease compared those darunavir, does not increase serum bilirubin. METHODS AND RESULTS: This was retrospective cohort study 1020 HIV. The main outcome time myocardial...