A5102884707- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Streptococcal Infections and Treatments
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- MicroRNA in disease regulation
- Antimicrobial Resistance in Staphylococcus
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- Neonatal and Maternal Infections
- Bacillus and Francisella bacterial research
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- Infective Endocarditis Diagnosis and Management
- Barrier Structure and Function Studies
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Viral Infections and Outbreaks Research
- Infectious Diseases and Tuberculosis
- Orthopedic Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Infectious Aortic and Vascular Conditions
- Pancreatitis Pathology and Treatment
University of Oklahoma Health Sciences Center
2016-2025
OU Health
2008-2022
University of Oklahoma
2001-2020
Oklahoma State University Oklahoma City
2020
Oklahoma City University
2005-2009
Veterans Health Administration
1996-2005
Williams (United States)
2003-2005
Texas Tech University
2001-2004
Texas Tech University Health Sciences Center
2001-2004
Oklahoma State University
2004
Background & AimsPancreatic cancer has the highest prevalence of cancer-associated cachexia among all cancers. ZIP4 promotes pancreatic progression by regulating oncogenic miR-373, and perturbation circular RNAs (circRNAs) is associated with aggressiveness. This study aimed to identify circRNAs involved in ZIP4/miR-373–driven growth decipher underlying mechanism.MethodsDifferentially expressed potential targets microRNA were identified through silico analysis. The RNA interactions determined...
With limited treatment options, cachexia remains a major challenge for patients with cancer. Characterizing the interplay between tumor cells and immune microenvironment may help identify potential therapeutic targets cancer cachexia. Herein, we investigate critical role of macrophages in potentiating pancreatic induced muscle wasting via promoting TWEAK (TNF-like weak inducer apoptosis) secretion from tumor. Specifically, depletion reverses degradation by cells. Macrophages induce...
Robert Koch's discovery of the anthrax bacillus in 1876 launched field medical bacteriology. A 'golden age' scientific ensued. century after death, we remember his life and work.
There is evidence suggesting that Sydenham's chorea, which a major manifestation of acute rheumatic fever, may be mediated by streptococcal antibodies cross-react with the brain. Our studies were undertaken to determine whether M protein, virulence factor group A streptococci, evoked human Rabbits immunized pepsin-extracted protein from rheumatogenic type 6 streptococci. Immune sera screened for presence cross-reacted brain indirect immunofluorescence tests and immunoblot analyses. Type...
More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a protein, overexpressed in colorectal cancer and specifically marks tumor stem cells (TSCs) that self-renew increased progeny Apc Min/+ mice. However, role Dclk1 expression its contribution to regulating pro-survival signaling for progression mutant poorly understood.We analyzed DCLK1 gene datasets 329 specimens from TCGA Colon Adenocarcinoma Cancer...
To study the role of group A streptococcal capsule in pharyngeal colonization, we used two acapsular mutants derived from a type 24 strain Streptococcus by transposon mutagenesis. One mutant had stable phenotype due to transposon-associated chromosomal deletion essential synthetic genes, while second could revert encapsulated at low frequency (< 10(-4)) upon spontaneous excision capsule-synthesis region chromosome. Both were sensitive phagocytic killing vitro and reduced virulence mice after...
Hepatitis C virus (HCV) infection is a prominent risk factor for the development of hepatocellular carcinoma (HCC). Similar to most solid tumors, HCCs are believed contain poorly differentiated cancer stem cell-like cells (CSCs) that initiate tumorigenesis and confer resistance chemotherapy. In these studies, we demonstrate expression an HCV subgenomic replicon in cultured results acquisition CSC traits. These traits include enhanced doublecortin CaM kinase-like-1 (DCAMKL-1), Lgr5, CD133,...
ZIP4 is overexpressed in human pancreatic cancer and promotes tumor growth. However, little known about the role of advanced stages this dismal neoplasm. Our goal to study underlying mechanism define a novel signaling pathway controlled by ZIP4-modulating metastasis.
Renal cell carcinoma (RCC) is a common and devastating disease characterized by hypoxic microenvironment, epithelial‐mesenchymal transition potent resistance to therapy evidencing the presence of cancer stem cells (CSCs). Various CSC markers have been studied in RCC, but overall there limited data on their role most relatively nonspecific. Doublecortin‐like kinase 1 (DCLK1) validated marker gastrointestinal tract evidence for an equivalent other cancers accumulating. We used bioinformatics,...
Patients with unresolving acute respiratory distress syndrome (ARDS) have persistently elevated levels of proinflammatory cytokines in the lungs and circulation increased rates bacterial infections. Phagocytic cells hyperactivated lipopolysaccharide (LPS), which induces high monocytic cells, are inefficient killing ingested bacteria despite having intact phagocytic activity. On other hand, that activated an analogue LPS does not induce expression effectively ingest kill bacteria. We...
The present studies were undertaken to identify conserved epitopes of group A streptococcal M proteins that evoke cross-protective mucosal immune responses. Two synthetic peptides copying regions type 5 protein, designated SM5(235-264)C and SM5(265-291)C, covalently linked carrier molecules their immunogenicity was tested in laboratory animals. Rabbit antisera against both cross-reacted with multiple serotypes streptococci, indicating the contained broadly cross-reactive, surface exposed...