Nicholas G. Brown

ORCID: 0000-0003-0339-7026
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About
Contact & Profiles
Research Areas
  • Pancreatic and Hepatic Oncology Research
  • Gallbladder and Bile Duct Disorders
  • Pediatric Hepatobiliary Diseases and Treatments
  • Pancreatitis Pathology and Treatment
  • Esophageal and GI Pathology
  • Gastrointestinal disorders and treatments
  • COVID-19 Clinical Research Studies
  • Biliary and Gastrointestinal Fistulas
  • Long-Term Effects of COVID-19
  • Genetics and Neurodevelopmental Disorders
  • Foreign Body Medical Cases
  • Ubiquitin and proteasome pathways
  • Autoimmune and Inflammatory Disorders
  • Gastrointestinal Tumor Research and Treatment
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Organ Transplantation Techniques and Outcomes
  • Inflammatory Bowel Disease
  • DNA Repair Mechanisms
  • Gastrointestinal Bleeding Diagnosis and Treatment
  • Liver Disease and Transplantation
  • Congenital Anomalies and Fetal Surgery
  • Thermal Regulation in Medicine
  • Computational Drug Discovery Methods
  • Pneumothorax, Barotrauma, Emphysema
  • Machine Learning in Materials Science

Columbia University Irving Medical Center
2020-2024

University of North Carolina Health Care
2024

University of North Carolina at Chapel Hill
2024

Cornell University
2024

NewYork–Presbyterian Brooklyn Methodist Hospital
2024

Texas Health Dallas
2020-2022

Columbia University
2020

University of Cincinnati
2019

University of Colorado Anschutz Medical Campus
2013-2018

University of Cincinnati Medical Center
2018

B. Joseph Elmunzer Rebecca L. Spitzer Lydia D. Foster Ambreen A. Merchant Eric F. Howard and 95 more Vaishali Patel Mary K. West Emad Qayed Rosemary Nustas Ali Zakaria Marc S. Piper Jason R. Taylor Lujain Jaza Nauzer Forbes Millie Chau Luis F. Lara Georgios I. Papachristou Michael L. Volk Liam Hilson Selena Zhou Vladimir Kushnir Alexandria Lenyo Caroline G. McLeod Sunil Amin Gabriela Kuftinec Dhiraj Yadav Charlie Fox Jennifer M. Kolb Swati Pawa Rishi Pawa Andrew Canakis Christopher Huang Laith H. Jamil Andrew M. Aneese Benita K. Glamour Zachary L. Smith Katherine A. Hanley Jordan Wood Harsh K. Patel Janak N. Shah Emil Agarunov Amrita Sethi Evan L. Fogel Gail McNulty Abdul Haseeb Judy A. Trieu Rebekah E. Dixon Jeong Yun Yang Robin B. Mendelsohn Delia Calo Olga C. Aroniadis Joseph F. LaComb James M. Scheiman Bryan G. Sauer Duyen T. Dang Cyrus Piraka Eric D. Shah Heiko Pohl William M. Tierney Stephanie L. Mitchell Ashwinee Condon Adrienne Lenhart Kulwinder S. Dua Vikram Kanagala Ayesha Kamal Vikesh K. Singh María Inés Pinto-Sánchez Joy M. Hutchinson Richard S. Kwon Sheryl Korsnes Harminder Singh Zahra Solati Field F. Willingham Patrick Yachimski Darwin L. Conwell Evan Mosier Mohamed Azab Anish Patel James Buxbaum Sachin Wani Amitabh Chak Amy Hosmer Rajesh N. Keswani Christopher J. DiMaio Michael S. Bronze M. Raman Marcia I. Canto V. Mihajlo Gjeorgjievski Zaid Imam Fadi Odish Ahmed I. Edhi Molly Orosey Abhinav Tiwari Soumil Patwardhan Nicholas G. Brown Anish Patel Collins O. Ordiah Ian Sloan Lilian Cruz Casey L. Koza

10.1016/j.cgh.2020.09.041 article EN Clinical Gastroenterology and Hepatology 2020-10-01
B. Joseph Elmunzer Bethany J. Wolf James M. Scheiman William M. Tierney Jason R. Taylor and 95 more Ambreen A. Merchant Vaishali Patel Field F. Willingham Eric F. Howard Mary K. West Casey L. Koza Patrick Yachimski Emad Qayed Rosemary Nustas Ali Zakaria Marc S. Piper Lujain Jaza Nauzer Forbes Millie Chau Luis F. Lara Georgios I. Papachristou Uchechi Okafor Darwin L. Conwell Michael L. Volk Evan Mosier Mohamed Azab Anish Patel Liam Hilson Selena Zhou James Buxbaum Vladimir Kushnir Alexandria Lenyo Ian Sloan Thomas Hollander Caroline G. McLeod Rebecca L. Spitzer Lauren Wakefield Haley Nitchie Collins O. Ordiah Don C. Rockey Teldon B. Alford Sunil Amin Gabriela Kuftinec Amar R. Deshpande Dhiraj Yadav Melissa Saul Melanie Mays Gülsüm Anderson Kelley Wood Laura Mathews Charlie Fox Jennifer M. Kolb Sachin Wani Swati Pawa Rishi Pawa Andrew Canakis Christopher Huang Laith H. Jamil Andrew M. Aneese V. Mihajlo Gjeorgjievski Zaid Imam Fadi Odish Ahmed I. Edhi Molly Orosey Abhinav Tiwari Soumil Patwardhan Benita K. Glamour Zachary L. Smith Amy Hosmer Nancy Furey Amitabh Chak Katherine A. Hanley Jordan Wood Rajesh N. Keswani Harsh K. Patel Janak N. Shah Emil Agarunov Nicholas G. Brown Anish Patel Amrita Sethi Evan L. Fogel Gail McNulty Abdul Haseeb Judy A. Trieu Rebekah E. Dixon Jeong Yun Yang Christopher J. DiMaio Robin B. Mendelsohn Delia Calo Olga C. Aroniadis Joseph F. LaComb Lilian Cruz Olga Reykhart Bryan G. Sauer Galina Diakova Duyen T. Dang Cyrus Piraka Eric D. Shah Molly Caisse Natalia Zbib

Recent studies have suggested that proton pump inhibitor (PPI) use may increase the risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and worsen course COVID-19.1Almario C.V. et al.Am J Gastroenterol. 2020; 115: 1707-1715Crossref PubMed Scopus (146) Google Scholar,2Lee S.W. al.Gut. 2021; 70: 76-84Crossref (145) Scholar This observation is biologically plausible, as gastric acid a well-established line defense against microbial pathogens, including...

10.1053/j.gastro.2020.11.007 article EN other-oa Gastroenterology 2020-11-12

EUS-guided radiofrequency ablation (RFA) is an endoscopic procedure and emerging therapeutic option for the treatment of pancreatic tumors.1Kim H.J. Seo D.W. Hassanuddin A. et al.EUS-guided porcine pancreas.Gastrointest Endosc. 2012; 76: 1039-1043Abstract Full Text PDF PubMed Scopus (61) Google Scholar, 2Armellini E. Crinò S. Ballare M. al.Endoscopic ultrasound-guided a neuroendocrine tumor.Endoscopy. 2015; 47: E600-E601Crossref (37) 3Ligresti D. Amata Luca B. small adenocarcinoma: new...

10.1016/j.vgie.2020.07.021 article EN cc-by-nc-nd VideoGIE 2020-08-29

10.1016/j.giec.2024.02.008 article EN Gastrointestinal Endoscopy Clinics of North America 2024-04-08

Intraductal papillary mucinous neoplasms (IPMNs) are epithelial treated with surgical resection when appropriate. We present a 79-year-old man jandice refractory to endoscopic stenting. Biliary radiofrequency ablation (RFA) cholangioscopy was used as palliation of obstructive jaundice due mucin-producing pancreatic IPMN fistulous biliary communication. Clinical improvement permitted surgery, and he returned pre-illness status at 17 months. The use in the setting filling defects can guide...

10.14309/crj.2016.50 article EN cc-by-nc-nd ACG Case Reports Journal 2016-01-01

Objectives: Advanced ERCP techniques (AETs) for difficult biliary stones include peroral cholangioscopy (POC) with electrohydraulic/laser lithotripsy (EHL/LL), endoscopic papillary large balloon dilation (EPLBD) and mechanical (ML). We assess the efficacy of AETs.Methods: A retrospective query AETs. Primary outcome: Complete duct clearance. Secondary clearance by technique. Statistical Analysis version 9.3 (SAS Inc., Cary, NC).Results: From 1/00 to 10/12, 349 patients were identified which...

10.1080/00365521.2018.1441434 article EN Scandinavian Journal of Gastroenterology 2018-04-12

The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. However, factors that prevent premature unloading and replisome disassembly are poorly described. Since catalyzed by ubiquitination, deubiquitinases (DUBs) represent attractive candidates for safeguarding against untimely deleterious unloading. We combined targeted loss-of-function screen quantitative,...

10.1101/2024.09.03.610997 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-09-03

Introduction: In liver transplant centers, ERCP is a necessary tool in managing post-transplant complications such as strictures and biliary leaks. Post-ERCP pancreatitis (PEP) can be devastating adverse event this fragile patient population. Animal models have demonstrated protective effect of tacrolimus on acute pancreatic inflammation with reduction histologic inflammation, amylase, IL-6 levels. Data human subjects yet to published. OBJECTIVE: Assess the clinical efficacy therapy reducing...

10.14309/00000434-201810001-00788 article EN The American Journal of Gastroenterology 2018-10-01

Aim: To compare outcomes by sedation class in community patients undergoing index endoscopic retrograde cholangiopancreatography (ERCP). Methods: Nineteen hundred sixteen consecutive underwent ERCP from May 2005 to 2011. Eight thirty seven were excluded due prior papillary intervention or attempted ERCP. A total of 1079 included. The 981 who gastroenterologist directed (GDS) served as the control population, while 98 received anesthesiologist (ADS) case population. Medical records analyzed...

10.4236/ojgas.2016.62007 article EN Open Journal of Gastroenterology 2016-01-01

The risk of solid organ malignancy in patients on anti-TNF therapy has been described. However, new therapies for treatment IBD continue to emerge and safety data regarding use with active is lacking. We describe a case series two at the time initiation ustekinumab therapy. followed these mean 35 weeks both without evidence tumor recurrence or progression are clinically well. 1: A 47-year-old man ALS stricturing ileolonic CD adalimumab presented management his IBD. He known distal ileal...

10.14309/00000434-201810001-02088 article EN The American Journal of Gastroenterology 2018-10-01
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