A5081560075- Micro and Nano Robotics
- Pickering emulsions and particle stabilization
- Force Microscopy Techniques and Applications
- Advanced Thermodynamics and Statistical Mechanics
- Glycosylation and Glycoproteins Research
- Material Dynamics and Properties
- Cellular Mechanics and Interactions
- Biotin and Related Studies
- Ubiquitin and proteasome pathways
- Slime Mold and Myxomycetes Research
- Orthopaedic implants and arthroplasty
- Adhesion, Friction, and Surface Interactions
- Mechanical and Optical Resonators
- Modular Robots and Swarm Intelligence
- Higher Education and Employability
- Protein Kinase Regulation and GTPase Signaling
- Advanced Electron Microscopy Techniques and Applications
- Molecular Junctions and Nanostructures
- Lipid Membrane Structure and Behavior
- Advanced Materials and Mechanics
- Microtubule and mitosis dynamics
- Dental Implant Techniques and Outcomes
- Stochastic processes and statistical mechanics
- Experimental and Theoretical Physics Studies
- Surgical site infection prevention
Humboldt State University
2023-2025
California State Polytechnic University
2023-2025
California Polytechnic State University
2023
University of the Pacific
2017-2022
Stockton University
2019
Massachusetts Institute of Technology
2014-2016
Abstract The self-organization of active particles is governed by their dynamic effective interactions. Such interactions are controlled the medium in which such agents reside. Here we study between a dense non-active medium. Our system consists actuated, spinning, embedded monolayer passive, or non-active, particles. We demonstrate that presence passive alters markedly properties and results reversal forces spinning from repulsive to attractive. origin due coupling stresses elasticity...
The mechanisms that underlie the extensive phenotypic diversity in genetic disorders are poorly understood. Here, we develop a large-scale assay to characterize functional valence (gain or loss-of-function) of missense variants identified UBE3A, gene whose loss-of-function causes neurodevelopmental disorder Angelman syndrome. We identify numerous gain-of-function including hyperactivating Q588E mutation strikingly increases UBE3A activity above wild-type levels. Mice carrying exhibit...
Background: Tungsten carbide rings are increasingly popular modern jewelry items. is an extremely dense, hard metal. Previously described methods to remove tungsten include using locking pliers compress the ring or cutting with a high-speed dental drill. Methods: A universal mechanical testing system (MTS) machine was used diametrically 9 mm in length and 2.4 thickness 23.4-mm outer diameter 21.0-mm inner while measuring force required fracture rings. computer numerical control (CNC) cut...
Particle-particle interactions determine the state of a system. Control over range such as well their magnitude has been an active area research for decades due to fundamental challenges it poses in science and technology. Very recently, effective between particles have gathered much attention they can lead out-of-equilibrium cooperative states flocking. Inspired by nature, where living cells coexist with lifeless objects structures, here we study that appear systems composed passive...
Abstract Substrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along enzymatic process. So far, how any ubiquitin ligase builds proteasomal degradation signal, which canonically regarded as four or more ubiquitins, remains unclear. Here we present time-resolved cryogenic...
Friction, the resistive force between two surfaces sliding past each other, is at core of a wide diversity locomotion schemes. While such schemes are well described for homogeneous environments, based on friction in inhomogeneous environments has not received much attention. Here we introduce and demonstrate concept tribotaxis, motion that guided by gradients coefficient. Our system composed microwalkers undergo an effective frictional interaction with biological receptors substrate, which...
Polyubiquitination by E2 and E3 enzymes is crucial to cell cycle control, epigenetic regulation, development. The hallmark of the family ubiquitin (Ub)-conjugating (UBC) domain that forms a dynamic thioester conjugate with (E2~Ub). Numerous studies have focused on surfaces, such as N-terminal crossover helices, directly interact an or conjugated stabilize active, "closed" state E2~Ub. However, it remains unclear how other surfaces regulate transfer. Here, we demonstrate helix-turn-helix...
Active matter systems are able to exhibit emergent non-equilibrium behavior due activity-induced effective interactions between the active particles. Here we study aggregation and dynamical of rotating particles, spinners, embedded in 2D passive colloidal monolayers. Using both experiments simulations observe particles or spinners whose resembles classical Cahn-Hilliard coarsening. The spinner attraction depend on mechanical properties monolayer activity spinners. Spinner only occurs when...
Measuring protein-protein interaction (PPI) affinities is fundamental to biochemistry. Yet, conventional methods rely upon the law of mass action and cannot measure many PPIs due a scarcity reagents limitations in measurable affinity ranges. Here, we present novel technique that leverages concept friction produce mechanical signal correlates binding potential. The mechanically transduced immunosorbent (METRIS) assay utilizes rolling magnetic probes PPI affinities. METRIS measures...
Friction, the resistive force between two surfaces sliding past each other, is at core of a wide diversity locomotion schemes. While such schemes are somewhat understood for homogeneous environments, based on friction in inhomogeneous environments has not received much attention. Here, we introduce and demonstrate concept tribotaxis by utilizing microwalkers that detect gradients coefficient controlled density biological receptors substrate. When actuated stochastically, these migrate to...
Active matter systems are able to exhibit emergent non-equilibrium states due activity-induced effective interactions between the active particles. Here we study aggregation and dynamical behavior of rotating particles, spinners, embedded in 2D passive colloidal monolayers, which constitutes one such process. Using both experiments simulations observe particles or spinners whose resembles classical coarsening. The spinner attraction depends on mechanical properties monolayer activity...