A5024804370- Medical Imaging Techniques and Applications
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- CAR-T cell therapy research
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Advanced Breast Cancer Therapies
- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- MRI in cancer diagnosis
- Chronic Lymphocytic Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Biosimilars and Bioanalytical Methods
- Advanced MRI Techniques and Applications
- Cancer Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Cells and Metastasis
Fred Hutch Cancer Center
2015-2025
University of Washington
2016-2025
University of Washington Medical Center
2011-2024
American Society of Clinical Oncology
2024
Seattle Cancer Care Alliance
2012-2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2023
Seattle University
2007-2022
Cancer Consortium
2016-2022
Dartmouth College
2021
Sarah Cannon
2014-2018
Purpose There is a lack of treatments providing survival benefit for patients with metastatic triple-negative breast cancer (mTNBC), no standard care. A randomized phase II trial showed significant gemcitabine, carboplatin, and iniparib (GCI) over gemcitabine carboplatin (GC) in clinical rate, response progression-free (PFS), overall (OS). Here, we formally compare the efficacy these regimens III trial. Patients Methods stage IV/locally recurrent TNBC who had received more than two previous...
Dendritic cells (DCs) are bone marrow-derived leukocytes that function as potent antigen presenting capable of initiating T cell-dependent responses from quiescent lymphocytes. DC pulsed with tumor-associated (TAA) peptide or protein have recently been demonstrated to elicit antigen-specific protective antitumor immunity in a number murine models. Transduction DCs TAA genes may allow stable, prolonged expression well the potential for presentation multiple, unidentified, epitopes association...
Purpose Patients with locally advanced breast carcinoma (LABC) receive preoperative chemotherapy to provide early systemic treatment and assess in vivo tumor response. Serial positron emission tomography (PET) has been shown predict pathologic response this setting. We evaluated serial quantitative PET blood flow (BF) metabolism as measurements patient outcome. Methods Fifty-three women primary LABC underwent dynamic [ 18 F]fluorodeoxyglucose (FDG) 15 O]water scans before at midpoint of...
To determine, by molecular imaging, how in vivo pharmacodynamics of estrogen-estrogen receptor (ER) binding differ between types standard endocrine therapy.
Abstract Purpose: GSK2126458 (GSK458) is a potent inhibitor of PI3K (α, β, γ, and δ), with preclinical studies demonstrating broad antitumor activity. We performed first-in-human phase I study in patients advanced solid tumors. Materials Methods: Patients received oral GSK458 once or twice daily dose-escalation design to define the maximum tolerated dose (MTD). Expansion cohorts evaluated pharmacodynamics, pharmacokinetics, clinical activity histologically molecularly defined cohorts....
Cisplatin is synergistic with vinorelbine and the PARP inhibitor veliparib, has antineoplastic activity in triple-negative breast cancer (TNBC) BRCA mutation-associated cancer. This phase I study assessed veliparib cisplatin vinorelbine.A 3+3 dose-escalation design evaluated administered twice daily for 14 days (75 mg/m(2) day 1) (25 1, 8) every 21 days, 6 to 10 cycles, followed by monotherapy. Pharmacokinetics, measurement of poly(ADP-ribose) peripheral blood mononuclear cells, preliminary...
Changes in tumor metabolism from positron emission tomography (PET) locally advanced breast cancer (LABC) patients treated with neoadjuvant chemotherapy (NC) are predictive of pathologic response. Serial dynamic [(18)F]-FDG (fluorodeoxyglucose) PET scans were used to compare kinetic parameters the standardized uptake value (SUV) as predictors response, disease-free survival (DFS), and overall (OS).Seventy-five LABC underwent FDG prior at midpoint NC. delivery (K(1)), flux (K(i)), SUV...
Our objective was to determine whether early change in standardized uptake values (SUVs) of 3′deoxy-3′-<sup>18</sup>F-fluorothymidine (<sup>18</sup>F-FLT) using PET with CT could predict pathologic complete response (pCR) primary breast cancer neoadjuvant chemotherapy (NAC). The key secondary correlate SUV the proliferation marker Ki-67 at baseline and after NAC. <b>Methods:</b> This prospective, multicenter phase II study did not specify therapeutic regimen, thus, NAC varied among centers....
Abstract Background LIV-1, a transmembrane protein and downstream target of STAT3, is highly expressed in breast cancer cells. It associated with lymph node involvement metastatic progression. SGN-LIV1A an anti-LIV-1 antibody conjugated via protease-cleavable linker to monomethyl auristatin E (MMAE). Upon binding cell-surface internalized releases MMAE, which disrupts microtubulin induces apoptosis. Methods This ongoing, phase 1 study evaluates safety, tolerability, pharmacokinetics,...
Abstract Purpose: Dynamic positron emission tomography (PET) imaging can identify patterns of breast cancer metabolism and perfusion in patients receiving neoadjuvant chemotherapy (NC) that are predictive response. This analysis examines tumor by subtype. Experimental Design: Tumor subtype was defined immunohistochemistry 71 with locally advanced undergoing NC. Subtype as luminal [estrogen receptor (ER)/progesterone (PR) positive], triple negative [TN; ER/PR negative, human epidermal growth...
The most common site of metastasis for breast cancer is bone. Quantitative <sup>18</sup>F-fluoride PET can estimate the kinetics fluoride incorporation into bone as a measure transport, formation, and turnover. purpose this analysis was to evaluate accuracy precision model parameter estimates characterizing regional in metastases normal patients. <b>Methods:</b> Twenty metastatic patients underwent dynamic PET. Mean activity concentrations were measured from serial blood samples regions...
Assessing therapy response of breast cancer bone metastases is challenging. In retrospective studies, serial <sup>18</sup>F-FDG PET was predictive time to skeletal-related events (tSRE) and progression (TTP). <sup>18</sup>F-NaF improves metastasis detection compared with scanning. We prospectively tested predict tSRE, TTP, overall survival (OS) in patients bone-dominant metastatic (MBC). <b>Methods:</b> Patients MBC were imaged before starting new (scan1) again at a range times centered...
Predictive biomarkers to identify patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer who may benefit from targeted therapy alone are required. We hypothesized that early measurements of tumor maximum standardized uptake values corrected for lean body mass (SULmax) on [18F]fluorodeoxyglucose positron emission tomography/computed tomography would predict pathologic complete response (pCR) neoadjuvant pertuzumab and trastuzumab (PT).Patients stage II/III,...
Predictive biomarkers to identify patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer who may benefit from targeted therapy alone are required. We hypothesized that early measurements of tumor maximum standardized uptake value corrected for lean body mass (SULmax) on 18F-labeled fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) would predict pathologic complete response (pCR) pertuzumab and trastuzumab (PT).Patients stage II or III,...
Opioid-active substances have been isolated from bovine β-casein peptone (β-casomorphin). Since the ingestion of β-casomorphin-containing foodstuff elicits an increase inpostprandial insulin release, present study was designed todetermine effects iv infused β-casomorphins on insulinrelease. The infusion β-casomorphin-7, -5, -4, and -3 did notalter basal secretion. During prestimulation release with amino acids glucose at a dose 1 nmol/kg· augmented whereas concentration 100 nmol/kg·h no...
Abstract Purpose: The receptor tyrosine kinase–like orphan 1 (ROR1) is expressed in hematopoietic and epithelial cancers but has limited expression on normal adult tissues. This phase I study evaluated the safety of targeting ROR1 with autologous T lymphocytes engineered to express a chimeric antigen (CAR). Secondary objectives persistence, trafficking, antitumor activity CAR-T cells. Patients Methods: Twenty-one patients ROR1+ tumors received cells at one four dose levels: 3.3 × 105, 106,...
Abstract Purpose To investigate the relationship between changes in vascularity and metabolic activity measured by dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) 18 F‐FDG‐positron emission tomography (PET) breast tumors undergoing neoadjuvant chemotherapy. Materials Methods PET MRI examinations were performed 14 patients with locally advanced cancer (LABC) before after Dynamic F‐FDG measures included transport rate constant from blood to tissue (K 1 ) metabolism flux (Ki)....