A5043359058- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Synthesis and Biological Evaluation
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Calcium signaling and nucleotide metabolism
- Immune Cell Function and Interaction
Fred Hutch Cancer Center
2019-2025
Galapagos (Netherlands)
2023
Cancer Research Center
2019
Abstract Purpose: The receptor tyrosine kinase–like orphan 1 (ROR1) is expressed in hematopoietic and epithelial cancers but has limited expression on normal adult tissues. This phase I study evaluated the safety of targeting ROR1 with autologous T lymphocytes engineered to express a chimeric antigen (CAR). Secondary objectives persistence, trafficking, antitumor activity CAR-T cells. Patients Methods: Twenty-one patients ROR1+ tumors received cells at one four dose levels: 3.3 × 105, 106,...
<p>Supplementary Figure 1: Strobe Flow Diagram.</p>
<p>Supplementary Figure 4: Flow cytometric analysis of T cell phenotypes in apheresis, infusion products and EGFRt + CAR cells at peak expansion.</p>
<div>AbstractPurpose:<p>The receptor tyrosine kinase–like orphan 1 (ROR1) is expressed in hematopoietic and epithelial cancers but has limited expression on normal adult tissues. This phase I study evaluated the safety of targeting ROR1 with autologous T lymphocytes engineered to express a chimeric antigen (CAR). Secondary objectives persistence, trafficking, antitumor activity CAR-T cells.</p>Patients Methods:<p>Twenty-one patients ROR1<sup>+</sup> tumors...
<p>Supplementary Figure 3: Lymphodepletion and CAR T cell expansion.</p>
<p>Supplementary Data 1: Study Protocol.</p>
<p>Supplementary Figure 2: Toxicity Assessment.</p>