A5076488821- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Nutrition and Health in Aging
- Frailty in Older Adults
- Speech and dialogue systems
- Renal Transplantation Outcomes and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Clinical Nutrition and Gastroenterology
- Personal Information Management and User Behavior
- Usability and User Interface Design
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Organ Donation and Transplantation
- Liver Diseases and Immunity
- Dialysis and Renal Disease Management
- AI in Service Interactions
- Natural Language Processing Techniques
- Adolescent and Pediatric Healthcare
- Machine Learning in Healthcare
- Hepatitis B Virus Studies
- Optimism, Hope, and Well-being
University of California, San Francisco
2016-2025
Oregon Health & Science University
2024
University of Calgary
2024
University of California San Francisco Medical Center
2024
Dongguan People’s Hospital
2024
Southern Medical University
2024
University of San Francisco
2019-2023
University of Vermont
2023
Universidad Católica de Santa Fe
2023
University of Colorado Anschutz Medical Campus
2022
In this paper we describe a statistical technique for aligning sentences with their translations in two parallel corpora.In addition to certain anchor points that are available our da.ta, the only information about use calculating alignments is number of tokens they contain.Because make no lexical details sentence, alignment computation fast and therefore practical application very large collections text.We have used align several million English-French Hans~trd corpora achieved an accuracy...
We aimed to determine whether frailty, a validated geriatric construct of increased vulnerability physiologic stressors, predicts mortality in liver transplant candidates. Consecutive adult outpatients listed for with laboratory Model End-Stage Liver Disease (MELD) ≥ 12 at single center (97% recruitment rate) underwent four frailty assessments: Fried Frailty, Short Physical Performance Battery (SPPB), Activities Daily Living (ADL) and Instrumental ADL (IADL) scales. Competing risks models...
Supported by the American Association for Study of Liver Diseases. Dr. Lai is partially supported R01 AG059183 and R21 AG067554. Srinivasan Dasarathy NIH RO1 GM119174; DK113196; P50 AA024333; AA021890; 3U01AA026976 ‐ 03S1; UO1 AA 026976; R56HL141744;UO1 DK061732; 5U01 DK062470‐17S2. Potential conflict interest: received grants from Axcella Lipocine. Bernal advises Versantis. Purpose Scope This Practice Guidance first Diseases (AASLD) practice guidance on management malnutrition, frailty,...
Cirrhosis is characterized by muscle wasting, malnutrition, and functional decline that confer excess mortality not well quantified the Model for End‐Stage Liver Disease (MELD) Sodium (MELDNa) score. We aimed to develop a frailty index capture these extrahepatic complications of cirrhosis enhance prediction in patients with cirrhosis. Consecutive outpatients listed liver transplantation at single transplant center without MELD exceptions were assessed candidate measures. Best subset...
Sarcopenia is associated with increased wait‐list mortality, but a standard definition lacking. In this retrospective study, we sought to determine the optimal of sarcopenia in end‐stage liver disease (ESLD) patients awaiting transplantation (LT). Included were 396 newly listed for LT 2012 at 5 North American transplant centers. All computed tomography scans read by 2 individuals interobserver correlation 98%. Using image analysis software, total cross‐sectional area (cm ) abdominal skeletal...
We present an estimate of upper bound 1.75 bits for the entropy characters in printed English, obtained by constructing a word trigram model and then computing cross-entropy between this balanced sample English text. suggest well-known widely available Brown Corpus as standard against which to measure progress language modeling offer our first what we hope will be series steadily decreasing bounds.
The North American Consortium for the Study of End‐Stage Liver Disease's definition acute‐on‐chronic liver failure (NACSELD‐ACLF) as two or more extrahepatic organ failures has been proposed a simple bedside tool to assess risk mortality in hospitalized patients with cirrhosis. We validated NACSELD‐ACLF's ability predict 30‐day survival (defined in‐hospital death hospice discharge) separate multicenter prospectively enrolled cohort both infected and uninfected used NACSELD database 14...
Frailty has emerged as a powerful predictor of outcomes in patients with cirrhosis and inevitably made its way into decision making within liver transplantation. In an effort to harmonize integration the concept frailty among transplant centers, AST ASTS supported efforts our working group develop this statement from experts field. is multidimensional construct that represents end-manifestation derangements multiple physiologic systems leading decreased reserve increased vulnerability health...
Loss of muscle mass and function, or sarcopenia, is a common feature cirrhosis contributes significantly to morbidity mortality in this population. Sarcopenia main indicator adverse outcomes population, including poor quality life, hepatic decompensation, patients with evaluated for liver transplantation (LT), longer hospital intensive care unit stay, higher incidence infection following LT, overall health cost. Although it clear that an important predictor LT outcomes, many questions...
A consensus conference on frailty in kidney, liver, heart, and lung transplantation sponsored by the American Society of Transplantation (AST) endorsed Nephrology (ASN), Transplant Surgeons (ASTS), Canadian (CST) took place February 11, 2018 Phoenix, Arizona. Input from transplant community through scheduled calls enabled wide discussion current concepts frailty, exploration best practices for risk assessment candidates management after transplant, development ideas future research....
Since its release as a “research preview” in November 2022, ChatGPT, the conversational interface to Generative Pretrained Transformer 3 large language model built by OpenAI, has garnered significant publicity for ability generate detailed responses variety of questions. ChatGPT and other models sentences paragraphs response word patterns training data that they have previously seen. By allowing users communicate with an artificial intelligence human-like way, however, crossed technological...
Background and Aims: Large language models (LLMs) have significant capabilities in clinical information processing tasks. Commercially available LLMs, however, are not optimized for uses prone to generating hallucinatory information. Retrieval-augmented generation (RAG) is an enterprise architecture that allows the embedding of customized data into LLMs. This approach “specializes” LLMs thought reduce hallucinations. Approach Results We developed “LiVersa,” a liver disease–specific LLM, by...
article Guidelines for multimodal user interface design Authors: Leah M. Reeves View Profile , Jennifer Lai James A. Larson Sharon Oviatt T. S. Balaji Stéphanie Buisine Penny Collings Phil Cohen Ben Kraal Jean-Claude Martin Michael McTear TV Raman Kay Stanney Hui Su Qian Ying Wang Authors Info & Claims Communications of the ACMVolume 47Issue 1January 2004 pp 57–59https://doi.org/10.1145/962081.962106Published:01 January 2004Publication History 158citation9,088DownloadsMetricsTotal...
Cirrhosis is characterized by sarcopenia and malnutrition, leading to progressive functional decline. We aimed objectively measure decline in patients with cirrhosis awaiting liver transplantation its association waiting list mortality. Consecutive adults listed for laboratory Model End‐Stage Liver Disease (MELD) ≥12 at a single center underwent status assessments every outpatient visit using the Short Physical Performance Battery (0 = impaired 12 robust), consisting of gait, chair stands,...
Our goal was to compare direct quantitation of circulating free 25-hydroxyvitamin D (25(OH)D)levels calculated 25(OH)D levels and their relationships intact PTH (iPTH), a biomarker effect, in humans with range clinical conditions.Serum samples data were collected from 155 people: 111 without cirrhosis or pregnancy (comparison group), 24 cirrhotic patients albumin <2.9 g/dL, 20 pregnant women (second third trimester). Total (LC/MS/MS), (immunoassay), vitamin binding protein (DBP) albumin,...
OBJECTIVES: Frailty, a critical determinant of health outcomes, is most commonly assessed in patients with cirrhosis by general clinician assessment that limited its subjectivity. We aimed to compare the objective Liver Frailty Index (LFI), consisting three performance-based tests (grip, chair stands, balance), subjective hepatologist assessment. METHODS: Outpatients awaiting liver transplantation (LT) underwent: (1) measurement using LFI and (2) Spearman's correlation associations between...
Sarcopenia and functional impairment are common lethal extrahepatic manifestations of cirrhosis. We aimed to determine the association between computed tomography (CT)-based measures muscle mass quality (sarcopenia) performance-based function.Adults listed for liver transplant underwent testing function (grip strength, Short Physical Performance Battery [SPPB]) within 3 months abdominal CT. Muscle (cm/m) = total cross-sectional area psoas, paraspinal, wall muscles at L3 on CT, normalized...
AIMTo investigate the impact of physical frailty on risk hospitalisation in cirrhotic patients liver transplant waitlist.
Frailty is prevalent in liver transplant candidates, but little known of what happens to frailty after transplantation. We analyzed data for 214 adult recipients who had ≥1 assessment using the Liver Index (LFI) at 3- (n = 178), 6- 139), or 12- 107) months posttransplant (higher values=more frail). "Frail" and "robust" were defined as LFI ≥4.5 <3.2. Median pre-liver was 3.7, worse 3 (3.9; P .02), similar 6 (3.7; .07), improved 12 (3.4; < .001). The percentage robust pre- 3-, 6-, 12-months...