A5030131283- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Barrier Structure and Function Studies
- MicroRNA in disease regulation
- Inflammatory Bowel Disease
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Electrochemical sensors and biosensors
- Cancer Cells and Metastasis
- Whipple's Disease and Interleukins
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Advanced biosensing and bioanalysis techniques
- Microscopic Colitis
- Analytical Chemistry and Sensors
- Connexins and lens biology
- Frailty in Older Adults
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
University of California, San Francisco
2025
Rutgers, The State University of New Jersey
2015-2021
Rutgers New Jersey Medical School
2015-2021
College of New Jersey
2013
Mammalian small intestinal tight junctions (TJ) link epithelial cells to one another and function as a permselective barrier, strictly modulating the passage of ions macromolecules through pore leak pathways, respectively, thereby preventing absorption harmful compounds microbes while allowing regulated transport nutrients electrolytes. Small permeability is ascribed primarily properties TJs between adjoining enterocytes (ENTs), because there almost no information on TJ composition...
Intraepithelial lymphocytes (IELs) expressing the γδ TCR (γδ IELs) provide continuous surveillance of intestinal epithelium. However, mechanisms regulating basal motility these cells within epithelial compartment have not been well defined. We investigated whether IL-15 contributes to IEL localization and migratory behavior in addition its role differentiation survival. Using advanced live cell imaging techniques mice, we find that compartmentalized overexpression lamina propria shifts...
Background: It is unknown how frailty evolves over time in patients with hepatocellular carcinoma (HCC) who are treated locoregional therapies (LRTs). Methods: We conducted a retrospective study of LRT-treated HCC Liver Frailty Index (LFI) assessments. Linear mixed effects modeling was used to assess the impact (modeled linearly per month) and other variables on LFI. Results: Of 201 enrolled, median baseline LFI 3.54. did not change significantly from entry (p=0.93). Conclusions: In our...
Mammalian small intestinal (SI) tight junctions (TJ) link epithelial cells to one another and function as aperm selective barrier, strictly modulating the passage of ions macromolecules through “pore” “leak” pathways, respectively, thereby preventing absorption harmful compounds microbes while allowing regulated transport nutrients electrolytes. SI permeability is ascribed primarily properties TJ between adjoiningenterocytes (ENT), because there almost no information on composition...
Summary Excessive shedding of enterocytes into the intestinal lumen is observed in inflammatory bowel disease and correlated with relapse. However, mechanisms underlying this phenomenon remain unclear. Intraepithelial lymphocytes (IEL) expressing γδ T-cell receptor (TCR) provide surveillance mucosa at steady-state, which regulated, part, by CD103. Intravital microscopy lipopolysaccharide (LPS)-treated mice revealed that IELs make extended contact enterocytes. These prolonged interactions...
Positioned between intestinal epithelial cells in the lateral intercellular space, intraepithelial lymphocytes (IEL) expressing γΔ T cell receptor exhibit a surveillance‐like migratory behavior, which is required to limit microbial invasion. Epithelial interleukin (IL)‐15 critical for development, proliferation and survival of IELs; however, role IL‐15 IEL migration remains unclear. Transpresentation membrane bound requires cell‐cell contact activating responder cells, thus based on direct...