A5101788541- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Geomechanics and Mining Engineering
- Genetic Syndromes and Imprinting
- Metabolism, Diabetes, and Cancer
- Parathyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Geoscience and Mining Technology
- Clusterin in disease pathology
- Power Systems and Technologies
- Simulation and Modeling Applications
- Advanced Sensor and Control Systems
- Advanced Measurement and Detection Methods
- Civil and Geotechnical Engineering Research
- Geochemistry and Geochronology of Asian Mineral Deposits
- Metallurgy and Material Forming
- Genetic and Kidney Cyst Diseases
- Geotechnical Engineering and Underground Structures
- Geotechnical and Geomechanical Engineering
- Coastal and Marine Dynamics
- Pancreatic function and diabetes
- Covalent Organic Framework Applications
- Ocean Waves and Remote Sensing
- Advanced Algorithms and Applications
- Biochemical Analysis and Sensing Techniques
Anhui Polytechnic University
2021-2024
Jilin University
2023
North China University of Water Resources and Electric Power
2023
Greenville College
2019-2023
East Carolina University
2013-2022
Affiliated Hospital of Taishan Medical University
2022
Shandong First Medical University
2022
Harvard University
2012-2020
Beth Israel Deaconess Medical Center
2012-2020
Xi'an University of Technology
2017
Obesity-induced endoplasmic reticulum (ER) stress causes chronic inflammation in adipose tissue and steatosis the liver, eventually leads to insulin resistance type 2 diabetes (T2D). The goal of this study was understand mechanisms by which administration bilirubin, a powerful antioxidant, reduces hyperglycemia ameliorates obesity leptin-receptor-deficient (db/db) diet-induced obese (DIO) mouse models. db/db or DIO mice were injected with bilirubin vehicle ip. Blood glucose body weight...
A role of Rho-associated coiled-coil-containing protein kinase (ROCK)1 in regulating whole-body glucose homeostasis has been reported. However, cell-autonomous effects ROCK1 on insulin-dependent transport adipocytes and muscle cells have not elucidated. To determine the specific directly, expression 3T3-L1 L6 myoblasts was biologically modulated. Here, we show that small interfering RNA-mediated depletion decreased insulin-induced myoblasts, whereas adenovirus-mediated increased this a...
Alzheimer’s disease is a neurodegenerative disorder that affects the central nervous system. In this study, we characterized and examined early metabolic changes in triple transgenic mouse AD model (3xtg-AD), their relationship with hypothalamus, key regulator of metabolism We observed 3xtg-AD exhibited significantly higher oxygen consumption as well food intake before reported amyloid plaque formation, indicating abnormalities occurred at onset compared counterparts. Analysis gene...
Obesity is a major risk factor for developing nonalcoholic fatty liver disease (NAFLD). NAFLD the most common form of chronic and closely associated with insulin resistance, ultimately leading to cirrhosis hepatocellular carcinoma. However, knowledge intracellular regulators obesity-linked remains incomplete. Here we showed that hepatic Rho-kinase 1 (ROCK1) drives obesity-induced steatosis in mice through stimulation de novo lipogenesis. Mice lacking ROCK1 were resistant diet-induced obesity...
Exercise plays a critical role in regulating glucose homeostasis and body weight. However, the mechanism of exercise on metabolic functions associated with CNS has not been fully understood. C57BL6 male mice (n=45) were divided into three groups: normal chow diet, high-fat diet (HFD) treatment, HFD along voluntary running wheel training for 12 weeks. Metabolic function was examined by Comprehensive Lab Animal Monitoring System magnetic resonance imaging; phenotypic analysis included...
Abstract Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating metabolism, are to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting metabolism insulin sensitivity through low-density lipoprotein receptor-related protein-2 (LRP2)-dependent mechanism, coupled with the receptor (IR) signaling cascade. In muscle, LRP2 necessary insulin-dependent IR...
α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation cell proliferation, enhanced buffering reactive oxygen species. However, the role α-Klotho in regulation energy metabolism is complex poorly understood. Here we investigated 5 weeks peripheral administration high fat diet induced obese mice. Food intake, blood glucose, body weight were measured daily. Energy expenditure was determined with...
Rho kinase (ROCK) isoforms regulate insulin signaling and glucose metabolism negatively or positively in cultured cell lines skeletal muscle. However, the vivo function of ROCK1 isoform adipose tissue has not been addressed. To determine specific role development resistance obesity, mice lacking globally selectively were studied. Here, we show that insulin's ability to activate IRS-1/PI3K/Akt was greatly enhanced −/− compared with wild-type mice. These effects resulted from inhibitory effect...
Stance detection predicts attitudes towards targets in texts and has gained attention with the rise of social media. Traditional approaches include conventional machine learning, early deep neural networks, pre-trained fine-tuning models. However, evolution very large language models (VLPLMs) like ChatGPT (GPT-3.5), traditional methods face deployment challenges. The parameter-free Chain-of-Thought (CoT) approach, not requiring backpropagation training, emerged as a promising alternative....
INT131 is a potent non-thiazolidinedione (TZD)-selective peroxisome proliferator-activated receptor-γ modulator being developed for the treatment of type 2 diabetes. In preclinical studies and phase II clinical trial, has been shown to lower glucose levels ameliorate insulin resistance without typical TZD side effects. To determine whether insulin-sensitizing action mediated by effects on insulin-mediated homeostasis signaling, high-fat diet-induced obese (DIO) insulin-resistant mice treated...
Normal leptin signaling is essential for the maintenance of body weight homeostasis. Proopiomelanocortin- and agouti-related peptide (AgRP)-producing neurons play critical roles in regulating energy metabolism. Our recent work demonstrates that deletion Rho-kinase 1 (ROCK1) AgRP mice increased adiposity. Here, we report selective loss ROCK1 caused a significant decrease expenditure locomotor activity mice. These effects were independent any change food intake. Furthermore, neuron-specific...
Adiponectin is an adipocyte-derived factor that plays a pivotal role in lipid and glucose metabolism. Recently, two types of adiponectin receptors (AdipoR1 AdipoR2) were identified. We investigated whether exercise training (ET) or dietary restriction (DR) affects the expression skeletal muscle liver, thereby improving metabolism KKAy mice. mice subjected to 8 weeks food restriction. Following experimental protocol, intravenous tolerance test intraperitoneal insulin performed addition...
Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate molecular effectors central arcuate nucleus hypothalamus (ARC), while further deciphering its role regulating energy balance both humans Cerebrospinal fluid (CSF) was collected from 22 adults undergoing lower limb orthopedic surgeries, correlations between body weight were determined using an...