A5087881264- Regulation of Appetite and Obesity
- Genetic Syndromes and Imprinting
- Parathyroid Disorders and Treatments
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Clinical Nutrition and Gastroenterology
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Sports Performance and Training
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle activation and electromyography studies
- Pancreatic function and diabetes
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Dietary Effects on Health
- Protein Kinase Regulation and GTPase Signaling
- Drug Transport and Resistance Mechanisms
- Muscle metabolism and nutrition
East Carolina University
2020-2023
Greenville College
2023
George Mason University
2020-2021
Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate molecular effectors central arcuate nucleus hypothalamus (ARC), while further deciphering its role regulating energy balance both humans Cerebrospinal fluid (CSF) was collected from 22 adults undergoing lower limb orthopedic surgeries, correlations between body weight were determined using an...
Abstract A central question in the field of aging research is to identify cellular and molecular basis neuroresilience. One potential candidate small GTPase, Rab10. Here, we used Rab10 +/− mice investigate mechanisms underlying Rab10-mediated Brain expression analysis 880 genes involved neurodegeneration showed that have increased activation pathways associated with neuronal metabolism, structural integrity, neurotransmission, neuroplasticity compared their +/+ littermates. Lower was...
Recent evidence identifies a potent role for aerobic exercise to modulate the activity of hypothalamic neurons related appetite; however, these studies have been primarily performed in male rodents. Since females markedly different neuronal mechanisms regulating food intake, current study aimed determine effects acute treadmill on neuron populations involved appetite female mice. Mature, untrained mice were exposed sedentary, low- (10 m/min), moderate- (14 and high (18 m/min)-intensity...
Emerging evidence identifies a potent role for aerobic exercise to modulate activity of neurons involved in regulating appetite; however, these studies produce conflicting results. These discrepancies may be, part, due methodological differences, including differences intensity and pre-exercise energy status. Consequently, the current study utilized translational, well-controlled, within-subject, treadmill protocol investigate differential effects status on post-exercise feeding behavior...
Indirect calorimetry (IC) is considered the gold standard for assessing resting metabolic rate (RMR). However, many people do not have access to IC devices and use prediction equations RMR estimation. Equations using fat free mass (FFM) as a predictor been developed estimate RMR, strong relationship exists between FFM RMR. One such equation Nelson which used by BodPod (BP). Yet, there limited evidence whether superior other common predict To examine agreement predicted from BP, measured via...
Age-predicted maximal heart rate (APMHR) is an essential measure for health care professionals in determining cardiovascular response to exercise testing, exertion during exercise, and prescription. Although multiple prediction equations have been validated specific populations, the criterion validity of each use a general population requires testing. PURPOSE: To evaluate agreement between measured max (HRmax) with APMHR population. METHODS: HRmax from 99 graded treadmill tests (GXT) at...
Obesity remains a growing epidemic as current treatment approaches have limited success. We recently identified hypothalamic α-Klotho novel metabolic regulator; however, the downstream pathways remain unclear. Using Cre-dependent CRISPR/Cas9 system alongside transgenic mice to investigate role of FGFR1 in defined neuron populations adult mice, we show that deletion AgRP neurons results increased weight gain and adiposity, worsened glucose tolerance, liver lipid accumulation. Mechanistically,...