A5052829488- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Liver physiology and pathology
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Nutrition and Health in Aging
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Biliary and Gastrointestinal Fistulas
- Neuroendocrine Tumor Research Advances
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Renal cell carcinoma treatment
- Colorectal and Anal Carcinomas
Nagoya University
2016-2025
National Cancer Center
2023
Kagoshima University
2022
Nagoya University Hospital
2012-2020
Tokyo Medical and Dental University
2020
The University of Texas MD Anderson Cancer Center
2018
University Hospital of Geneva
2014
Geneva College
2014
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2014
Asan Medical Center
2014
To review our 34-year experience with 574 consecutive resections for perihilar cholangiocarcinoma and to evaluate the progress made in surgical treatment of this disease.Few studies have reported improved outcomes cholangiocarcinoma; therefore, it is still unclear whether intractable disease has progressed.Between April 1977 December 2010, a total 754 patients were treated, whom (76.1%) underwent resection. The medical records these resected retrospectively reviewed.The incidence major...
Abstract Background Few larger studies have estimated the incidence of incisional hernia (IH) after abdominal surgery. Methods Patients who had surgery between November 2009 and February 2011 were included in study. The rate risk factors for IH monitored at least 180 days. Results A total 4305 consecutive patients registered. Of these, 378 excluded because failure to complete follow-up 3927 analysed. was diagnosed 318 patients. rates 5·2 per cent 12 months 10·3 24 months. In multivariable...
The Japanese Society of Hepato-Biliary-Pancreatic Surgery launched the clinical practice guidelines for management biliary tract cancers (cholangiocarcinoma, gallbladder cancer, and ampullary cancer) in 2007, then published 2nd version 2014.In this 3rd version, questions (CQs) were proposed on six topics. recommendation, grade statement each CQ discussed finalized by an evidence-based approach. Recommendations graded as Grade 1 (strong) or 2 (weak) according to concepts Grading Assessment,...
Objective: Given the frequent adverse events with multidrug chemotherapy, not only survival benefit but also feasibility of using neoadjuvant chemotherapy to treat pancreatic cancer need be clarified. Summary Background Data: Although development regimens has improved outcomes patients unresectable cancer, benefits these treatments in neo-adjuvant setting remain controversial. Methods: Patients borderline-resectable were enrolled and randomly assigned receive either FOLFIRINOX or gemcitabine...
Abstract Background It is difficult to predict hepatic functional reserve accurately before major hepatectomy. The aim of this study was analyse the usefulness future liver remnant plasma clearance rate indocyanine green (ICGK-F, calculated as (ICGK) × proportion remnant) in predicting death after Methods Data on ICGK and ICGK-F were collected prospectively analysed retrospectively for 274 patients who underwent right hepatectomy, trisectionectomy or left biliary cancer between 1991 2008....
To outline our experience with hepatopancreatoduodenectomy (HPD) as a treatment for cholangiocarcinoma and to appraise the clinical significance of this challenging procedure.Cholangiocarcinomas often exhibit an extensive ductal spread invading from hepatic hilus lower bile duct, such tumors can be completely resected only by HPD. Early experiences HPD were associated high mortality morbidity, leading underestimation survival benefit HPD.We retrospectively reviewed medical records 85...
Abstract Objective To review our surgical experience with hilar cholangiocarcinoma in the “new era.” Methods The medical records of 428 patients who underwent treatment between 2001 and 2008 at First Department Surgery, Nagoya University Hospital, were retrospectively reviewed. Results Of patients, 298 (70%) resection (R0, n = 220; R1, 70; R2, 8). Portal vein was performed 111 (37%) hepatic artery 53 (18%) patients. Several different types postoperative complications occurred a total 129...
To review our experience with cholangiocarcinoma superficial spread, to clarify its clinical features, and discuss treatment strategies.Most of the previous reports on spread were case reports. Little is known about this type cholangiocarcinoma.The medical records 471 patients who underwent resection (351 perihilar 120 distal cancers) retrospectively reviewed, focusing which was defined as noninvasive cancer extension more than 20 mm.Superficial found in 69 (14.6%) patients, length 54 +/- 19...
To analyze lymph node status in resected perihilar cholangiocarcinoma, to clarify which index (ie, location, number, or ratio of involved nodes) is better for staging, and determine the minimum requirements examination.In TNM classification number nodes not considered nodal staging. The requirement histologic examination arbitrary.This study 320 patients with cholangiocarcinoma who underwent resection from January 2000 December 2009 at Nagoya University Hospital. relationship between patient...
<i>Backgrounds:</i> Portal vein embolization (PVE) has been widely applied before extended hepatectomy; however, its clinical utility for patients with biliary cancer not fully addressed. <i>Methods:</i> Between 1991 and 2010, 494 cholangiocarcinoma (n = 353) or gallbladder 141) underwent PVE hepatectomy. was performed by a transhepatic ipsilateral approach using fibrin glue absolute ethanol steel coils. Surgical outcomes of this cohort were retrospectively reviewed....
Bismuth type IV perihilar cholangiocarcinoma has traditionally been categorized as unresectable disease. The aim of this study was to review experience with a resection-based strategy in patients who have cholangiocarcinoma.Medical records consecutive diagnosis between 2006 and 2015 were reviewed retrospectively. Primary outcomes assessed surgical results long-term survival.Of the 332 tumour, 216 (65·1 per cent) underwent resection. Left hepatic trisectionectomy most common procedure (112...
We investigated the role of Nek2, a member serine‐threonine kinase family, in tumorigenic growth breast carcinoma. Increased expression Nek2 was observed all carcinoma cell lines examined (BT20, BT474, Hs578T, MCF7, MDA‐MB‐231, T47D, and ZR‐75‐1) by immunoblotting. By treatment with short interfering RNA (siRNA), clearly decreased both estrogen receptor (ER)‐positive (MCF7) ER‐negative (MDA‐MB‐231) lines. Cell growth, colony formation soft agar, vitro invasiveness these were substantially...
To review our experiences with left-sided hepatectomy for perihilar cholangiocarcinoma, to compare left trisectionectomy, and evaluate the clinical significance of trisectionectomy from viewpoint surgical oncology.Only 4 large case series have been reported on only a few patients diagnosed cholangiocarcinoma. Therefore, oncologic advantage compared cholangiocarcinoma is still unclear.This study involved 201 who underwent (86 trisectionectomies 115 hepatectomies). Surgical outcome survival...