A5042625391- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 and healthcare impacts
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Trauma and Emergency Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Abdominal Trauma and Injuries
- Microbial metabolism and enzyme function
- Surgical site infection prevention
- Colorectal and Anal Carcinomas
- Biliary and Gastrointestinal Fistulas
- Nitric Oxide and Endothelin Effects
- Ovarian cancer diagnosis and treatment
- Hepatitis B Virus Studies
Flinders University
2002-2024
Flinders Medical Centre
2014-2024
University of Birmingham
2020-2022
Institut de Virologie
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Abstract Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote restrain disease progression. Here, we interrogate how cells harboring distinct alterations in p53 manipulate CAFs. We reveal the existence a p53-driven hierarchy, where with gain-of-function (GOF) mutant educate dominant population CAFs that establish pro-metastatic environment for GOF null alike. also demonstrate educated by may be reprogrammed either or...
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups PanNETs, termed T1, T2 T3, distinct patterns methylation. The T1 subgroup was enriched for functional ATRX, DAXX MEN1 wild-type genotypes. contained mutations in recurrent chromosomal losses half genome no association between regions loss levels. were larger had lower MGMT gene body, which showed positive...
Globally, there has been a concerning rise in the incidence of young-onset cancers. The aim this study was to provide trends and survival gastrointestinal adenocarcinomas (oesophagus, stomach, pancreas, colorectal) South Australia over 27-year period.This is cross-sectional analysis prospective longitudinal database including all cases prospectively reported Australian (State) Cancer Registry from 1990 2017.A total 28,566 patients diagnosed with oesophageal, pancreatic, or colorectal...
Perianal sepsis is traditionally treated by incision and drainage, with packing of the residual cavity until healing. This study was designed to show that perianal abscess may be safely drainage alone.Healing times, analgesic requirements, pain scores, recurrence, fistula rates were compared between two randomized groups without cavities.Fifty patients recruited (7 lost follow-up): 20 in 23 nonpacking arm. The comparable terms age gender distribution, type size abscess, presence a at...
Pancreatic cancer (PC) has the worst survival of all periampullary cancers. This may relate to histopathological differences between pancreatic cancers and other Our aim was examine distribution histopathologic features pancreatic, ampullary, biliary duodenal resected with a pancreaticoduodenectomy (PD) local trends PD.A retrospective review PD January 2000 December 2012 at public metropolitan database performed. The institutional ethics committee approved this study.There were 142 PDs...
Since the Coronavirus disease-19(COVID-19) pandemic, healthcare systems are reallocating their medical resources, with consequent narrowed access to elective surgery for benign conditions such as gallstone disease(GD). This survey represents an overview of current policies regarding surgical management patients GD during COVID-19 pandemic.A Web-based was conducted among 36 Hepato-Prancreato-Biliary surgeons from 14 Countries. Through a 17-item questionnaire, participants were asked about...
Liver resection (LR) and liver transplantation (LT) are two modalities offering potential for cure in patients with hepatocellular carcinoma (HCC). The objective of this study was to evaluate the long-term survival HCC treated LT LR analyse variables influencing these outcomes.Patients referred South Australian Transplant Unit Hepatopancreatobiliary at Flinders Medical Centre from January 1992 September 2009 a diagnosis who underwent or were included study. Histopathological parameters...
Background: Expansion in liver transplantation (LT) criteria for HCC from Milan to UCSF has not adversely impacted overall survival, prompting further expansion towards Metroticket 2.0 (MT2). In this study, we compared patient survival post-transplant before and after 2007 long-term outcomes LT within versus (to determine the true benefit of criteria) retrospectively validated MT2 criteria. Methods: Retrospective analysis ANZLITR (including all patients transplanted since July 1997). The...
Objectives: Acute pancreatitis is associated with compromised pancreatic microcirculation. Galanin a vasoactive neuropeptide, but its role in the regulation of vascular perfusion (PVP) unclear. Methods: Localization galanin immunoreactivity was investigated by immunohistochemistry, and effects bolus doses or antagonist galantide on blood pressure (BP) PVP (by laser Doppler fluxmetry) were determined anesthetized possums. Results: abundant possum pancreas particularly around vessels....
Background . Autoimmune pancreatitis (AIP) often mimics pancreatic cancer. The diagnosis of both conditions is difficult preoperatively let alone when they coexist. Several reports have been published describing cancer in the setting AIP. Case Report case a 53-year-old man who presented with abdominal pain, jaundice, and radiological features autoimmune pancreatitis, “sausage-shaped” pancreas bulky head portal vein impingement, presented. He had normal serum IgG4 only mildly elevated...
The Wnt receptors ROR1 and ROR2 are generating increased interest as cancer therapeutic targets but remain understudied in pancreatic ductal adenocarcinoma (PDAC). Compared to canonical Wnt/ β-catenin signalling, the role of noncanonical signalling PDAC remains largely unknown. Only one study has investigated prognostic significance receptor, PDAC. No studies have PDAC.Here, we performed analysis mRNA expression three publicly available datasets ICGC-PACA-AU (n = 81), TCGA-PAAD 150)...
Abstract Patients with high model for end‐stage liver disease (MELD) scores waiting transplantation in Australia and New Zealand (ANZ) have had limited access to deceased donor livers therefore binational sharing of livers, patients a MELD score ≥35 was introduced February 2016. Waiting list mortality, post‐transplant outcomes intention‐to‐treat survival were compared between whose reached 35 on the October 2013 April 2015 (Pre‐Share group, n = 23) who Share listed 2016 May 2022 (Share 112)....
Inducible nitric oxide synthase (iNOS) plays a major role in acute pancreatitis. Selective inhibitors of iNOS are being developed as therapeutic agents. Sphincter Oddi (SO) dysfunction may cause pancreatitis and is necessary for SO relaxation. A new highly selective inhibitor, AR-C102222AA (AR-C), evaluated together with the established L-N(6)-(1-iminoethyl)lysine (L-NIL), neuronal (nNOS) blocker S-methyl-l-thiocitrulline (SMTC).In anaesthetized Australian Brush-tailed possums, effect...