A5037560875- Gastrointestinal motility and disorders
- Congenital gastrointestinal and neural anomalies
- Colorectal Cancer Surgical Treatments
- Neuropeptides and Animal Physiology
- Pelvic floor disorders treatments
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Anorectal Disease Treatments and Outcomes
- Infant Health and Development
- Diet and metabolism studies
- Hernia repair and management
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Intestinal Malrotation and Obstruction Disorders
- Diabetes Treatment and Management
- Genetic factors in colorectal cancer
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Ion Channels and Receptors
- Cardiac, Anesthesia and Surgical Outcomes
- Intestinal and Peritoneal Adhesions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Regulation of Appetite and Obesity
- Cancer survivorship and care
- Appendicitis Diagnosis and Management
Flinders Medical Centre
2016-2025
Flinders University
2016-2025
Monash University
2020
Women's and Children's Health Network
2019
Flinders Private Hospital
2009-2018
Queen Elizabeth Hospital
2003
Weatherford College
1998
The University of Adelaide
1992-1998
In-Q-Tel
1998
ACTA (United States)
1998
This trial examined the optimal setting for follow-up of patients after treatment colon cancer by either general practitioners or surgeons. In all, 203 consenting who had undergone potentially curative were randomised to Follow-up guidance recommended three monthly clinical review and annual faecal occult blood tests (FOBT) identical in both study arms. Primary outcome measures (measured at baseline, 12 24 months (1) quality life, SF-12; physical mental component scores, (2) anxiety...
Abstract Background The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly gene promoter regions. Specific genes, SEPT9 , VIM1 and TMEFF2 become methylated in a high fraction cancers diagnostic assays for detection cancer-derived DNA sequences blood and/or fecal samples are being developed. There considerable potential the new methylation biomarkers or panels to improve sensitivity specificity...
Metformin reduces plasma glucose and has been shown to increase glucagon-like peptide 1 (GLP-1) secretion. Whether this is a direct action of metformin on GLP-1 release, whether some the glucose-lowering effect occurs due unknown. The current study investigated metformin-induced secretion its contribution overall underlying mechanisms in patients with type 2 diabetes.Twelve diabetes were included placebo-controlled, double-blinded study. On 4 separate days, received (1,500 mg) or placebo...
Intestinal glucose stimulates secretion of the incretin hormone glucagon-like peptide 1 (GLP-1). The mechanisms underlying this pathway have not been fully investigated in humans. In study, we showed that a 30-min intraduodenal infusion activated half all duodenal L cells This was sufficient to increase plasma GLP-1 levels. With an ex vivo model using human gut tissue specimens, dose-responsive ileum at ≥200 mmol/L glucose. from duodenum and ileum, but colon, 300 potently stimulated release....
Abstract Background Slow transit constipation ( STC ) is associated with colonic motor abnormalities. The underlying cause(s) of the abnormalities remain poorly defined. In health, utilizing high resolution fiber‐optic manometry, we have described a distal propagating pattern slow wave frequency 2–6 cycles per minute (cpm). A calorie meal caused rapid and significant increase in this activity, suggesting intrinsic activity could be mediated by extrinsic neural input. Utilizing same protocol...
Abstract Objective Diverticular disease is common in our community. Most patients remain asymptomatic and the development of diverticular complications rare. A clinical observation that presenting with are obese. The aim this study was to examine relationship obesity disease. Methods based on a retrospective case note review conducted at Flinders Medical Centre between 1/7/1998 30/6/2003. Patients were identified using ICD codes their body mass index (BMI) calculated. Controls taken randomly...
The enteric nervous system (ENS) contains millions of neurons essential for organization motor behavior the intestine. It is well established that large intestine requires ENS activity to drive propulsive behaviors. However, firing pattern underlying propagating neurogenic contractions remains unknown. To identify this, we used high-resolution neuronal imaging with electrophysiology from neighboring smooth muscle. Myoelectric along murine [also referred as colonic migrating complexes,...
<b>Background:</b> Myenteric interneurones are involved in the reflexes that control motility of human colon. <b>Aims:</b> The distribution choline acetyltransferase (ChAT) and nitric oxide synthase (NOS) immunoreactivity myenteric was investigated this study. <b>Methods:</b> DiI (1,1`- didodecyl 3,3,3`,3`-indocarbocyanine perchlorate) applied to plexus colon followed by organotypic culture. Retrogradely labelled neurones, with projections longer than motor neurones (>10 mm), were studied...
Following the introduction and widespread acceptance of laparoscopic cholecystectomy, techniques have been applied to an increasing variety general surgical procedures. Recently, procedures for resection malignancy begun emerge, in particular assisted colectomy carcinoma colon. 1,2 In cases reported here, metastatic tumour laparoscopy port sites is described as a potentially serious complication malignancy.
While there is considerable research related to using differential gene expression predict disease phenotype classification, e.g., neoplastic tissue from nonneoplastic controls, little understanding of the range in normal tissues. Understanding patterns tissue, including regional anatomic changes within an organ, vital diseased tissue. To explore change along proximal-distal axis large intestine, we analyzed microarray data 184 human specimens univariate and multivariate techniques. We found...
Disorders of colonic motility, such as severe constipation and pseudo-obstruction, remain difficult to treat. The pathophysiology these conditions is not completely understood, but previous studies suggest a deficiency cholinergic innervation an imbalance in autonomic regulation motor function contributing factors. Therefore, increasing the availability acetylcholine bowel wall with cholinesterase inhibitor, pyridostigmine, may improve symptoms.We studied thirteen patients (slow transit...
Summary Background Ileus occurs after abdominal surgery and may be severe. Inhibition of prostaglandin release reduces post‐operative ileus in a rat model. Aim To determine whether inhibition by cyclooxygenase inhibitors, celecoxib or diclofenac, could enhance gastrointestinal recovery reduce humans. Methods Two hundred ten patients undergoing elective major were randomized to receive twice daily placebo ( n = 67), (100 mg, 74) diclofenac (50 69), preoperatively continuing for up 7 days....
Enterochromaffin (EC) cells are enteroendocrine that synthesise ∼95% of the body's total serotonin (5-HT). Although 5-HT release from EC plays a number important physiological roles, primary have not been studied at single cell level. This study provides first functional characterisation guinea-pig and human cells. large dense core vesicles in calcium-dependent manner with kinetics surprisingly resembling synaptic vesicles. 3D modelling indicates quantity released per vesicle fusion event is...
Inequalities in survival from colorectal cancer (CRC) across socioeconomic groups and by area of residence have been described various health care settings. Few population-wide datasets which include clinical treatment information are available Australia to investigate disparities. This study examines socio-demographic differences for CRC patients South (SA), using a database derived via linkage administrative surveillance datasets. The population comprised all cases diagnosed 2003-2008...
AbstractBackground: Faecal incontinence commonly affects women, principally because of childbirth. Our aims were to determine the functional effect childbirth on pressures generated by anal sphincter and patterns injury sphincter. Methods: Anal manometry was performed in 53 primiparous women prenatally, 50 at a median 5 weeks postnatally, repeated 26 6 months postnatally. In addition, ultrasound Pelvic floor symptoms assessed. The mode delivery examined what variables affected function....