A5088334524- Drug Transport and Resistance Mechanisms
- Gallbladder and Bile Duct Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Lipoproteins and Cardiovascular Health
- Drug Solubulity and Delivery Systems
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Legume Nitrogen Fixing Symbiosis
- Hormonal and reproductive studies
- Crystallization and Solubility Studies
- Kidney Stones and Urolithiasis Treatments
- Biliary and Gastrointestinal Fistulas
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Pharmacogenetics and Drug Metabolism
- Chronic Kidney Disease and Diabetes
- Pharmacology and Obesity Treatment
- Blood Pressure and Hypertension Studies
- Plant Micronutrient Interactions and Effects
- Neonatal Health and Biochemistry
- Porphyrin Metabolism and Disorders
University of Auckland
2024
Flinders Medical Centre
1986-2013
South Australia Pathology
2009-2010
Flinders University
1980-2009
The University of Sydney
2004
University of South Australia
1980-1983
Calvary Mater Newcastle Hospital
1983
The University of Adelaide
1976
The University of Western Australia
1974
The activity of phytanic acid oxidase is low in infantile and adult Refsum's disease, the cerebro‐hepato‐renal (Zellweger's) syndrome. plasma patients with but not form disease contains increased amounts pipecolic at least two abnormal bile acids, one which has been identified as 3α, 7α, 12α trihydroxy‐5β‐cholestan‐26‐oic acid. These changes are similar to those reported Zellweger syndrome indicate that there may be similarities metabolic defects Zellweger's disease.
The purification of hepatic delta-aminolevulinic acid synthase (EC 2.3.1.37) was accomplished from chick embryo liver mitochondria, which had been treated with the combination drugs, 2-allylisopropylacetamide and 1,4-dihydro-3,5-dicarbethoxycollidine to produce a high starting level enzyme activity. After extraction mitochondria by sonication, purified final specific activity over 10,000 nmol aminolevulinate formed/30 min/mg protein/37 degrees, using techniques Sephadex chromatography,...
Abstract Background Fibrates correct the typical lipid abnormalities of type 2 diabetes mellitus, yet no study, to date, has specifically set out evaluate role fibrate therapy in preventing cardiovascular events this setting. Methods Subjects with diabetes, aged 50–75 years, were screened for eligibility participate a long-term trial comicronized fenofibrate 200 mg daily compared matching placebo assess benefits treatment on occurrence coronary and other vascular events. People total...
The measurement of catecholamines and metanephrines in urine is an important diagnostic test biochemical screening for phaeochromocytoma. Tandem mass spectrometry (MSMS) has the potential to be used a profiling method simultaneous assay these analytes.Optimal conditions were established MSMS detection (noradrenalin, adrenalin dopamine) (normetanephrine metanephrine), including commercially available isotopically labelled compounds use as internal standards. Chromatographic separation all...
1. Postmitochondrial supernatants were prepared from the livers of chick embryos and incubated under conditions that supported protein synthesis. delta-Aminolaevulinate synthase (EC 2.3.1.37) was synthesized by treated with porphyrinogenic drugs 2-allyl-2-isopropylacetamide and/or 3,5-diethoxycarbonyl-1,4-dihydrocollidine, but synthesis normal could not be detected. Synthesis enzyme released polyribosomes measured immunoprecipitation specific antibody to mitochondrial enzyme, specificity...
Abstract The enzymatic assay of triglyceride, based on the use L-glycerol-3-phosphate oxidase (EC 1.1.3.21) and a modified Trinder's chromogen involving 4-chlorophenol, is subject to strong negative interference at concentrations triglyceride greater than 20 mmol/L, such as occur in grossly lipemic plasma. This caused by rapid utilization oxygen, resulting reaction becoming transiently anaerobic. dye product already formed may then be reduced ("bleached") acting an alternative electron...
The gallstones of 14 patients, who had been treated unsuccessfully with chenodeoxycholic acid (15 mg/kg/day) for at lest six months, were obtained cholecystectomy. stones then analysed their cholesterol and calcium content. Two patients' black in colour low content, classified as pigment stones. Of the remaining 12 stones, which all contained more than 70% cholesterol, 10 1% on stone surface. In two surface sufficient to form a radio-opaque layer, although radiolucent start dissolution...
Liver cells isolated from normal and cholestyramine-treated rats were incubated as cell suspensions for up to 4 h r in a simple, defined medium.T e bile acid concentration plus medium was determined by gas-liquid chromatography.Normal hepatocytes synthesized cholic at an Abbreviations: LHSA medium, modified L-15 with livers cannulated via the portal vein perfused added butter, albumin amino acids (7).(30 ml/min) situ Swim's S77 con-914
The prevalence of cholesterol gall stones in young women has increased since the introduction oral contraceptives. synthetic female sex hormones used these preparations, increase degree saturation bile. To determine whether oestrogens, progestagens, or both, are responsible for change biliary index, a prospective randomised, controlled study was performed. A significant index bile observed when either 30 micrograms ethinyloestradiol plus 150 norgestrel (p = 0.01) 50 250 less than were...
1. Cholesterol monohydrate crystal formation was measured quantitatively in model bile solutions, which were supersaturated with cholesterol, by a radiochemical method and qualitatively human gallbladder polarizing microscopy. 2. Various agents, have been postulated to act as nucleating factors for cholesterol gallstone formation, added their effect on the appearance of crystals determined. These agents included calcium salts found gallstones (calcite, aragonite, apatite, bilirubinate),...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuccinic Acid Crystal Growth Rates in Aqueous SolutionJ. W. Mullin and M. J. L. WhitingCite this: Ind. Eng. Chem. Fundamen. 1980, 19, 1, 117–121Publication Date (Print):February 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/i160073a020https://doi.org/10.1021/i160073a020research-articleACS PublicationsRequest reuse permissionsArticle Views542Altmetric-Citations26LEARN ABOUT THESE...
Abstract The common bile duct stones obtained from 148 patients were analysed chemically for cholesterol, calcium and bilirubin. When present in both the gallbladder at time of surgery, similar chemical composition to majority cases predominantly cholesterol-type stones. However, whose gallbladders had been removed least one year before detection contained less cholesterol more bilirubin than which associated with Thirty per cent these suture material centre stone. Overall, results indicate...
Cholesterol monohydrate crystal formation was studied in supersaturated model bile solutions, containing unlabeled cholesterol, sodium cholate and soybean phosphatidylcholine, tracer amounts of [SH]cholesterol.Solutions were either seeded with cholesterol crystals to initiate growth, or not allow self-nucleation subsequent growth occur.Crystal at 37°C measured by two methods.First, radioactive isolated filtration, the mass that had precipitated calculated.In unseeded there a long lag period...
Of 406 consecutive patients with gall-bladder stones, 387 were treated by cholecystectomy and 19 chenodeoxycholic acid.The gall stones found in 356 of the at operation analysed chemically for cholesterol calcium, physically number, size, mass, radiologically before stone lucency.Gall rich (>80% weight) present 75% patients, while pigment (<25% cholesterol) 12% patients.Out gall-stone 77 (19%) had functioning bladders which contained radiolucent 1.5 cm or less diameter, thereby fulfilling...