A5001026176- Lipoproteins and Cardiovascular Health
- Vitamin D Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acute Myocardial Infarction Research
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Retinal Diseases and Treatments
- Healthcare cost, quality, practices
- Cardiac Imaging and Diagnostics
- Breast Implant and Reconstruction
- Diabetes Management and Research
- Kruppel-like factors research
- Vitamin C and Antioxidants Research
- Coronary Interventions and Diagnostics
- Fibroblast Growth Factor Research
- Reconstructive Surgery and Microvascular Techniques
- Bone health and osteoporosis research
- Nutritional Studies and Diet
- Retinal Imaging and Analysis
- Contact Dermatitis and Allergies
- Liver Disease Diagnosis and Treatment
- Hemoglobin structure and function
- Chronic Kidney Disease and Diabetes
- Cardiac Health and Mental Health
- Hip disorders and treatments
The University of Sydney
2015-2024
National Health and Medical Research Council
2015-2024
Cooperative Trials Group for Neuro-Oncology
2014-2024
Nuffield Health
2024
University Hospitals Coventry and Warwickshire NHS Trust
2023
University of Bristol
2023
Wolverhampton Hospital
2023
The Royal Wolverhampton NHS Trust
2023
The Patients Association
2023
Manchester University NHS Foundation Trust
2023
Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk diabetes, but less is known about size or timing this effect, who at greatest risk. We aimed to address these gaps in knowledge through analysis individual participant large, long-term, randomised, double-blind therapy.
<h3>Importance</h3> The clinical phenotype and certain predisposing genetic mutations that confer increased melanoma risk are established; however, no consensus exists regarding optimal screening for such individuals. Early identification remains the most important intervention in reducing mortality. <h3>Objective</h3> To evaluate impact of full-body examinations every 6 months supported by dermoscopy total-body photography (TBP) on all patients sequential digital imaging (SDDI), when...
Fenofibrate is a peroxisome proliferator-activated receptor (PPAR)-α agonist that showed beneficial effects on total cardiovascular risk in patients with type 2 diabetes the Intervention and Event Lowering Diabetes (FIELD) study.This study aimed to investigate long-term effect of fenofibrate therapy three novel biomarkers risk, namely adipocyte-fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF21), retinol-binding 4 (RBP4), which are all downstream targets PPAR-α or...
Although the prognosis of most patients presenting with malignant pleural mesothelioma (MPM) is poor, a small proportion survives long term. We investigated factors associated survival in large patient series. All registered NSW Dust Diseases Board (2002–2009) were included an analysis prognostic using Kaplan–Meier and Cox regression analysis. On basis these analyses, we developed risk score (Prognostic Index (PI)). identified 910 patients: 90% male; histology (epithelioid 60%; biphasic 13%;...
Abstract Aims To investigate whether long-term glycemic variability (GV) is associated with vascular complication development in type 2 diabetes. Methods In a post hoc FIELD trial analysis, GV was calculated as the standard deviation and coefficient of variation (CV) glycated hemoglobin A1c (HbA1c) fasting plasma glucose. Baseline variables were compared across quartiles on-study by chi square ANOVA. Prospective associations between baseline to 2-year subsequent mortality outcomes analyzed...
Abstract Background Arthroscopic surgery for femoroacetabular impingement syndrome (FAI) is known to lead self-reported symptom improvement. In the context of surgical interventions with contextual effects and no true sham comparator trials, it important ascertain outcomes that are less susceptible placebo effects. The primary aim this trial was determine if study participants FAI who have hip arthroscopy demonstrate greater improvements in delayed gadolinium-enhanced magnetic resonance...
Abstract Background Falls cause considerable morbidity and mortality in older people. It is unclear how vitamin D supplementation affects falls risk, particularly when taken at high doses. We sought to determine whether monthly high‐dose reduces risk incidence of falls. Methods used data from the randomized, double‐blind, placebo‐controlled D‐Health Trial conducted Australia. Between February 2014 May 2015, 21 315 participants aged 60–84 years were randomized (1:1) doses either 60 000 IU...
Periprocedural myocardial infarction (MI) occurs in a significant proportion of patients undergoing percutaneous coronary intervention (PCI) and portends poor outcomes. Currently, no clinically applicable method predicts periprocedural MI the cardiac catheterization laboratory before it occurs. We hypothesized that impaired baseline microcirculatory reserve, which reduces ability to tolerate ischemic insults, is risk for index resistance (IMR) measured during PCI can predict occurrence...
Low HDL cholesterol (HDL-C) and small particle size may directly promote hyperglycemia. We evaluated associations of HDL-C, apolipoprotein A-I (apoA-I), HDL-C/apoA-I with insulin secretion, resistance, HbA1c, long-term glycemic deterioration, reflected by initiation pharmacologic glucose control.The 5-year Fenofibrate Intervention Event Lowering in Diabetes (FIELD) study followed 9,795 type 2 diabetic subjects. calculated baseline fasting apoA-I, HbA1c and, those not taking exogenous (n =...
<h3>Background</h3> Small vessel disease is reported to be a more common cause of ischaemic stroke in people with diabetes than others. However, population based studies have shown no difference between those and without the subtypes stroke. We determined rates predictors risk its Fenofibrate Intervention Event Lowering Diabetes (FIELD) trial. <h3>Methods</h3> 9795 patients aged 50–75 years type 2 were followed up for median 5 years. Annual derived by Kaplan–Meier method independent Cox...
A combination of conservative treatments is commonly used in clinical practice for thumb base osteoarthritis despite limited evidence this approach.To determine the efficacy a 6-week compared with an education comparator.Randomized, parallel trial 1:1 allocation ratio among people aged 40 years and older symptomatic radiographic community setting Australia.The intervention group (n = 102) received on self-management ergonomic principles, base-of-thumb splint, hand exercises, diclofenac...
Observational studies suggest a link between vitamin D and the composition of gut microbiome, but there is little evidence from randomized controlled trials supplementation. We analyzed data D-Health Trial, randomized, double-blind, placebo-controlled trial. recruited 21,315 Australians aged 60–84 y them to 60,000 IU D3 or placebo monthly for 5 y. Stool samples were collected sample 835 participants (417 in 418 group) approximately after randomization. characterized microbiome using 16S rRNA...
This study aims to determine whether the Charlson comorbidity index computed from ICD-9-CM discharge diagnosis codes adds additional information a model containing adjustment for more informed patient details (e.g., disease severity and history), besides solely age sex, when predicting long-term survival. We conducted retrospective cohort of patients admitted hospital suspected acute myocardial infarction. Index scores were calculated by applying D'Hoore et al. algorithm (1993). The...
Objective: To assess the effect of home-based health assessments for older Australians on health-related quality life, hospital and nursing home admissions, death. Design: Randomised controlled trial over 3 years. Participants setting: 1569 community-living veterans war widows receiving full benefits from Department Veterans' Affairs aged 70 years or were randomly selected in 1997 10 regions New South Wales Queensland allocated to receive either usual care (n = 627) 942). Intervention:...