A5059106943- Thyroid Cancer Diagnosis and Treatment
- Vitamin D Research Studies
- Thyroid Disorders and Treatments
- Retinal and Macular Surgery
- Thyroid and Parathyroid Surgery
- Global Cancer Incidence and Screening
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Healthcare cost, quality, practices
- Intraocular Surgery and Lenses
- Prostate Cancer Treatment and Research
- Meta-analysis and systematic reviews
- Growth Hormone and Insulin-like Growth Factors
- Gestational Diabetes Research and Management
- Bone health and osteoporosis research
- Vascular Malformations Diagnosis and Treatment
- Diabetes and associated disorders
- Neuroendocrine Tumor Research Advances
- Vitamin C and Antioxidants Research
- Climate Change and Health Impacts
- Pituitary Gland Disorders and Treatments
- Nutrition, Genetics, and Disease
- Health Systems, Economic Evaluations, Quality of Life
- Biomarkers in Disease Mechanisms
- Radiopharmaceutical Chemistry and Applications
Royal Brisbane and Women's Hospital
2016-2025
The University of Queensland
2015-2025
QIMR Berghofer Medical Research Institute
2015-2024
Indiana University School of Medicine
2023
Johns Hopkins Medicine
2011-2012
Johns Hopkins University
2011-2012
Mater Health Services
2010
Arrien Pharmaceuticals (United States)
2010
Cairns Hospital
2010
Brisbane School of Theology
2010
Abstract Objective To investigate whether supplementing older adults with monthly doses of vitamin D alters the incidence major cardiovascular events. Design Randomised, double blind, placebo controlled trial (the D-Health Trial). Computer generated permuted block randomisation was used to allocate treatments. Setting Australia from 2014 2020. Participants 21 315 participants aged 60-84 years at enrolment. Exclusion criteria were self-reported hypercalcaemia, hyperparathyroidism, kidney...
Quantitative, autoradiographic, or immunohistochemical light microscopy was conducted on 85 surgically excised epiretinal membranes to investigate the activities of component cells and natural history extraretinal scars. Membranes less than four months9 clinical duration (9early9 membranes) contained significantly more 9late9 membranes, while collagen abundant in older specimens. No correlation established between membrane opacification either cellularity content membranes. Epiretinal had...
Serum thyrotropin (TSH) concentration and thyroid autoimmunity may be of prognostic importance in differentiated cancer (DTC). Preoperative serum TSH level has been associated with higher DTC stage cross-sectional studies; data are contradictory on the significance at time diagnosis.We sought to assess whether preoperative perioperative antithyroglobulin antibodies (TgAb) were outcome patients followed by National Thyroid Cancer Treatment Cooperative Study, a large multicenter...
Concerns around possible overdiagnosis and overtreatment of differentiated thyroid cancer (DTC) have been raised. Issues concerning health-related quality life (HRQOL) after diagnosis treatment DTC are understudied in this patient group.To better understand the range HRQOL outcomes, including adverse effects treatment, associated with whether these outcomes vary by type surgery received.This content analysis assessed responses to an open-ended question about concerns among patients...
The relationship between Graves disease and race/ethnicity is undefined. Based on thyroid antibody prevalence, the rates of Hashimoto thyroiditis may be highest in whites lowest blacks.1,2 Using a large comprehensive data set medical diagnoses for all US active duty service personnel, we calculated age-standardized incidence by race/ethnicity.
Hypercalcemia is a common complication of cancer with PTHrP an important mediator. Literature on the underlying causes PTHrP-mediated hypercalcemia, in both malignant and benign conditions, limited to small case series reports.The purpose this study was systematically identify large cases hypercalcemia document differences demographics clinical course between etiologies.This hospital-based, retrospective that identified subjects from 1999 2010 public hospital system Queensland, Australia....
Summary Background Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others there a true increase. Increases in A ustralia appear to have among largest world, so we investigated trends ustralian state Q ueensland help understand reasons for rise. Methods cancers diagnoses 1982–2008 were ascertained from C ancer R egistry. We calculated age‐standardized rates ( ASR ) and used P oisson regression estimate...
Abstract Background Falls cause considerable morbidity and mortality in older people. It is unclear how vitamin D supplementation affects falls risk, particularly when taken at high doses. We sought to determine whether monthly high‐dose reduces risk incidence of falls. Methods used data from the randomized, double‐blind, placebo‐controlled D‐Health Trial conducted Australia. Between February 2014 May 2015, 21 315 participants aged 60–84 years were randomized (1:1) doses either 60 000 IU...
Hypercalcemia mediated by 1,25-dihydroxy vitamin D (calcitriol) is uncommon, with evidence on etiology limited to small case series or reports.The objective of the study was systematically identify a large cases calcitriol-mediated hypercalcemia and document presentation, demographics, clinical course across etiologies.The hospital-based, retrospective series, identifying subjects from 1999 through 2009 public hospital system in Queensland, Australia. All patients aged over 18 years were...
Race/ethnicity may be a newly recognized risk factor for Graves' disease.The aim of this study was to examine the prevalence thyrotoxicosis by race/ethnicity in Americans aged 12-49 years using three National Health and Nutritional Examination Surveys (NHANES).Data were analyzed from 17,939 participants NHANES III (1988-1994), 1999-2002, 2007-2010 with available thyroid function test results. Thyrotoxicosis defined as serum thyrotropin (TSH) ≤0.1 mIU/L or subjects taking methimazole...
Background: Thyroid cancer incidence has increased in many parts of the world since 1980s, as prevalence obesity. Evidence suggests that people with greater body size have higher thyroid risk. However, it is unclear whether this association causal or driven by over-diagnosis indolent cancers, because overweight/obese use health services more frequently than those normal weight, thus conferring opportunity for incidental diagnosis. Assessing obesity associated higher-risk cancers might help...
Thyroid autoimmunity has been associated with differentiated thyroid cancer although multiple potential biases might have influenced the results of previous studies.We conducted a case-control study nested within cohort US active-duty personnel 1996-2014 to assess association between autoimmunity, defined by serology, and diagnosis. The primary exposure was peroxidase (TPO) antibody status 7-10 years before index date. We also assessed whether diagnosis mediated any associations identified...
Sun exposure carries both harms and benefits. Exposing the skin to sun is main modifiable cause of cancers, which exert a considerable health economic burden in Australia. The most well-established benefit ultraviolet (UV) radiation vitamin D production. Australia has highest incidence cancer world but, despite high ambient UV radiation, approximately one quarter population estimated be deficient. Balancing risks benefits challenging requires effective communication. We sought provide...
Observational studies suggest a link between vitamin D and the composition of gut microbiome, but there is little evidence from randomized controlled trials supplementation. We analyzed data D-Health Trial, randomized, double-blind, placebo-controlled trial. recruited 21,315 Australians aged 60–84 y them to 60,000 IU D3 or placebo monthly for 5 y. Stool samples were collected sample 835 participants (417 in 418 group) approximately after randomization. characterized microbiome using 16S rRNA...