A5083319440- Ophthalmology and Eye Disorders
- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Advanced Differential Geometry Research
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Growth Hormone and Insulin-like Growth Factors
- Erythropoietin and Anemia Treatment
- interferon and immune responses
- Cancer-related Molecular Pathways
- Bone health and treatments
- Erythrocyte Function and Pathophysiology
- Glaucoma and retinal disorders
- BRCA gene mutations in cancer
- Mesenchymal stem cell research
- Nutrition and Health in Aging
- Vitamin D Research Studies
- ATP Synthase and ATPases Research
- Blood transfusion and management
- Genetics, Aging, and Longevity in Model Organisms
- Myofascial pain diagnosis and treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Drug-Induced Ocular Toxicity
Azienda Ospedaliera Universitaria Pisana
2016-2025
University of Pisa
2016-2025
University of Pennsylvania
2023-2024
Johns Hopkins University
2019-2023
Johns Hopkins Hospital
2022-2023
Johns Hopkins Medicine
2019-2022
Limited data suggest that treatment with statins is associated a reduced risk of Graves' orbitopathy (GO) in patients disease (GD), attributed to the anti-inflammatory rather than hypolipemic effects these medications. The aim present study was investigate whether there an association between high cholesterol and GO. primary outcome relation GO low-density lipoprotein (LDL)-cholesterol. secondary outcomes were severity or activity (the clinical score [CAS]) LDL-cholesterol.A cross-sectional...
<h3>Importance</h3> Graves orbitopathy (GO) responds to immunosuppressive treatments when clinically active but poorly inactive. In other autoimmune diseases, response has been ascribed a reduction in lymphocytes infiltrating the target organ. It is not known whether vs inactive GO differs this regard, which would help understanding link between immunologic features and clinical behavior. <h3>Objective</h3> To investigate association orbital lymphocytic infiltrate features. <h3>Design,...
The role of energy metabolism in bone cells is an active field investigation. Bone are metabolically very and require high levels the form adenosine triphosphate (ATP) to support their function. ATP generated cytosol via glycolysis coupled with lactic acid fermentation mitochondria oxidative phosphorylation (OXPHOS). OXPHOS final convergent metabolic pathway for all steps dietary nutrients catabolism. formation driven by electrochemical gradient that forms across mitochondrial inner membrane...
Thyroid autoimmunity has been associated with differentiated thyroid cancer although multiple potential biases might have influenced the results of previous studies.We conducted a case-control study nested within cohort US active-duty personnel 1996-2014 to assess association between autoimmunity, defined by serology, and diagnosis. The primary exposure was peroxidase (TPO) antibody status 7-10 years before index date. We also assessed whether diagnosis mediated any associations identified...
Objectives: There is a general belief that Graves' orbitopathy (GO) "chronic" disease, namely patients' eyes do not return to how they were before GO appeared. Here, we investigate this issue from both the patient's and physician's point of view. Study Design: We studied disappearance GO, regardless treatment, in all consecutive patients with history at least 10 years who came for follow-up visit over period 5 years. Patients underwent an ophthalmological examination asked answer...
The pathogenesis of thyroiditis caused by immune-checkpoint inhibitors (ICIs) such as antiprogrammed death receptor-1 (PD-1) and anticytotoxic T lymphocyte antigen-4 (CTLA-4) is incompletely understood. To gain mechanistic insights, we developed a mouse model ICI-related assessed the clinical, hormonal, cytokine profiles.
Papillary thyroid cancer (PTC) often co-occurs with Hashimoto's thyroiditis, an association that has long been reported in clinical studies yet remains controversial. Some studies, fact, have suggested a protective effect of thyroiditis while others not. We generated mouse model where PTC and develop predictable manner, combining the oncogenic drive BRAFv600E mutation (inducible by tamoxifen) to susceptibility NOD.H2h4 strain iodine). A total 113 NOD.H2h4_TPO-CRE-ER_BRAFV600E mice (50...
Aging and age-related diseases represent a compelling therapeutic goal for senolytics drugs targeting inflammatory or metabolic pathways. We compared MyMD-1, synthetic derivative of the alkaloid myosmine capable suppressing TNF-α production, to rapamycin, best characterized drug endowed with antiaging properties. In vivo, longitudinal cohort 54 C57BL/6 mice, 19-month-old at start, was randomized receive high-dose (126 ppm) low-dose (14 rapamycin plus metformin. Each treatment arm included 18...
Abstract Erythropoietin (EPO), primarily produced by interstitial fibroblasts in the kidney during adulthood, and its receptor are well-known for their crucial role regulating erythropoiesis. Recent research has unveiled an additional function of circulating EPO control bone mass accrual homeostasis through receptor, which is expressed both osteoblasts osteoclasts. Notably, cells osteoblast lineage can produce secrete functional upon activation hypoxia signaling pathway. However,...
Cytotoxic T lymphocyte-associated protein 4 (CTLA4), a negative regulator typically expressed on the surface of lymphocytes, is targeted by immunotherapy in patients with an ever-expanding spectrum cancers. Characterizing expression CTLA4 pituitary gland could provide additional rationale for using immune checkpoint inhibitors adenoma who do not respond to conventional treatments. We assessed mRNA and panel 157 human glands, 45 collected at autopsy 112 surgery. These specimens included 50...