A5021494317- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Regulation of Appetite and Obesity
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Circadian rhythm and melatonin
- Biochemical Analysis and Sensing Techniques
- Esophageal and GI Pathology
- Neuroscience and Neural Engineering
- Neuropeptides and Animal Physiology
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
Chiba University
2017-2025
Hokkaido University Hospital
2025
Tokyo Medical University
2019-2021
Weatherford College
2020
Odawara Municipal Hospital
2015
Soka Municipal Hospital
2013
Matsushiro Seismological Observatory
2013
The Jikei University Hospital
2012
Nagoya City University
1995-2006
Mizuho (Japan)
2004
Inflammation-based prognostic scores including the Glasgow Prognostic Score (GPS), neutrophil to lymphocyte ratio (NLR), and Nutritional Index (PNI) are associated with survival in patients hepatocellular carcinoma (HCC). The aim of this study was investigate value these inflammation-based HCC. In total, 150 newly diagnosed HCC were prospectively evaluated. Patients divided according GPS, modified NLR, platelet (PLR), (PI), PNI. area under receiver operating characteristics curve (AUC)...
The Brisbane 2000 Terminology for Liver Anatomy and Resections, based on Couinaud's segments, did not address how to identify segmental borders anatomic territories of less than one segment. Smaller resections including segmentectomies subsegmentectomies, have been well defined. advent minimally invasive liver resection has enhanced the possibilities more precise due a magnified view reduced bleeding, (MIALR) is becoming popular gradually. Therefore, there need updating system, segmentectomy...
Among other deficits, amygdalectomy impairs the ability of animal to recognize affective significance a stimulus. In present study, neuronal activity in amygdala (AM) was recorded from alert monkeys while they performed tasks leading presentation rewarding or aversive stimuli. Of 585 AM neurons tested, 312 (53.3%) responded at least one stimulus more 5 major groups: 40 vision related, 26 audition 41 ingestion 117 multimodal, and 14 selective. Ingestion-related were subdivided according their...
A novel murine cDNA which encodes a protein designated neuropsin was cloned. Northern and in situ hybridization analyses demonstrated that mRNA is expressed specifically the limbic system of mouse brain localized at highest concentration pyramidal neurons hippocampal CA1-3 subfields. Direct stimulation kindling induced by amygdaloid caused significant bilateral change level neurons. The activity-dependent changes specific localization indicate involved plasticity.
The concept of minimally invasive anatomic liver resection (MIALR) is gaining popularity. However, specific technical skills need to be acquired safely perform MIALR. "Expert Consensus Meeting: Precision Anatomy for Minimally Invasive HBP Surgery (PAM-HBP Consensus)" was developed as a special program during the 32nd meeting Japanese Society Hepato-Biliary-Pancreatic (JSHBPS).Thirty-four international experts gathered online consensus. A Research Committee performed comprehensive literature...
Neuronal activity in the amygdala (AM) was recorded from alert monkeys during performance of tasks that led to presentation rewarding or aversive stimuli. The had 3 phases: (1) discrimination (visual, auditory), (2) operant response (bar pressing), and (3) ingestion (reward) avoidance (aversion). analyzed compared each these phases. Of 585 AM neurons tested, 312 (53.3%) responded at least one stimulus more 5 major groups: vision related, audition multimodal, selective. Forty (6.8%) anterior...
Background Mesalazine suppositories are recommended and widely used as the standard therapy in induction maintenance of remission for proctitis. Aim To evaluate efficacy mesalazine patients with ulcerative colitis (UC) rectal inflammation; patient groups categorised by extent lesions. Methods This study was a phase III multicentre, randomised, double-blind, placebo-controlled, parallel-group study. Mild-to-moderate UC inflammation were randomly assigned either 1 g or placebo suppository. The...
1. Neurons in the amygdala are implicated mediating hedonic appreciation, emotional expression, and conditioning, particularly as these relate to feeding. The receives projections from primary taste cortex monkeys, offering a route by which it could gain access gustatory information required guide feeding behavior. We recorded activity of 35 neurons alert rhesus macaques response range intensities qualities characterize taste-evoked this area. 2. stimulus array comprised 26 chemicals,...
Abstract The epithelial‐mesenchymal transition ( EMT ) and mesenchymal‐epithelial MET contribute to cancer metastasis of pancreatic ductal adenocarcinoma PDAC ). We explored the role grainyhead‐like 2 GRHL 2), a suppressor , in progression . Expressions were assessed using surgically resected tissues by immunohistochemistry analysis, vitro human mouse cells. Effects on epithelial plasticity stemness examined liver metastatic cells CFPAC ‐1) with knockdown specific si RNA s. has significantly...
1. Extracellular single neuron activity was recorded in the lateral hypothalamic area (LHA) of awake, behaving monkeys, with particular regard to feeding-related functional characteristics glucose-sensitive (GS) versus glucose-insensitive (GIS) neurons. Firing rate changes were by means carbon fiber, multibarreled glass microelectrodes during 1) microelectrophoretic application various chemicals, 2) gustatory and olfactory stimulation, 3) a high fixed-ratio schedule (FR) bar press feeding...
1. The frequency of firing was simultaneously recorded from single neurones the ventromedial nuclei (VMN) and lateral hypothalamic area (LHA) in urethane anaesthetized rats for many hours. 2. There were circadian changes VMN LHA neurone activity. pattern this rhythm is as follows: throughout day show higher activity than that VMN, indicated by more fluctuations their rates firing. In late afternoon discharge rate increases further, showing oscillations short duration. early evening hours...
Although the number of minimally invasive liver resections (MILRs) has been steadily increasing in many institutions, anatomic resection (MIALR) remains a complicated procedure that not standardized. We present results survey among expert surgeons as benchmark for standardizing MIALR.We administered this to 34 who routinely perform MIALR. The contained questions on personal experience with resection, inflow/outflow control methods, and identification techniques intersegmental/sectional...
Abstract Introduction Assessment of right ventricular systolic function plays an important role in management cardiovascular disease. Tricuspid annular plane excursion (TAPSE) is the most widely used quantitative parameter; however, there a lack evidence regarding appropriate cut for its measurement. Purpose This study aimed to elucidate optimal TAPSE measurement, focusing on incidence angle M-mode cursor and relationship angle-independent parameter. Methods retrospective included 113 adult...
Percutaneous endoscopic gastrostomy (PEG) is commonly performed for enteral nutrition in patients with various diseases. However, there are few reports on abdominal surgeries after PEG, and the tips these procedures have not been established. Specifically, laparoscopic of upper abdomen, a can interfere surgical field. In addition, perioperative management concomitant diseases that require PEG placement, including neuromuscular disorders, required. A 64-year-old man due to malnutrition from...