A5053156849- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Tuberculosis Research and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Amino Acid Enzymes and Metabolism
- Psychiatric care and mental health services
- CAR-T cell therapy research
- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Synthesis and Catalytic Reactions
- Antibiotic Resistance in Bacteria
- Probiotics and Fermented Foods
- Catalytic C–H Functionalization Methods
- Cancer Research and Treatments
- Treatment of Major Depression
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Transgenic Plants and Applications
- Biopolymer Synthesis and Applications
- Signaling Pathways in Disease
- Alkaloids: synthesis and pharmacology
- Synthesis of heterocyclic compounds
Megmilk Snow Brand (Japan)
2024
Tohoku University
1994-2023
Futaba (Japan)
2020-2022
Shionogi (Japan)
1993-2022
Saitama Children's Medical Center
2017-2021
Hospital Sarikei
2009-2013
Nihon University
2012
Shibuya (Japan)
2008
Japan Pediatric Society
2008
Kyowa Kirin (Japan)
1992-2007
Abstract The objective of the present study was to evaluate association between suicidal ideation and potentially related factors in an elderly urban Japanese population. This a community‐based, cross‐sectional study. Urban community residents aged 70 years or more were interviewed regarding sociodemographic health‐related variables. Subjects with depressive symptoms underwent further evaluation by psychiatrists using criteria Diagnostic Statistical Manual Mental Disorders, 4th edition....
Visceral fat accumulation is considered to be associated with a higher risk of chronic diseases. We investigated the effects Bifidobacterium longum subsp. (B. longum) BB536 and breve breve) MCC1274 on body composition, including visceral fat, in randomized, parallel-group, placebo-controlled study. Participants were between 29 64 years age had mass index (BMI) greater than 23 less 30. One hundred participants randomly assigned probiotics group or placebo group. administered probiotic...
The present study examines the role of Pyk2 in acid regulation sodium/hydrogen exchanger 3 (NHE3) activity OKP cells, a kidney proximal tubule epithelial cell line. Incubation cells media caused transient increase phosphorylation that peaked at 30 seconds and increased Pyk2/c-Src binding 90 seconds. isolated by immunoprecipitation studied cell-free system was activated phosphorylated acidic pH. Acid activation (a) specific for did not activate focal adhesion kinase, (b) required calcium, (c)...
The present study examines the role of Pyk2 in acid regulation sodium/hydrogen exchanger 3 (NHE3) activity OKP cells, a kidney proximal tubule epithelial cell line. Incubation cells media caused transient increase phosphorylation that peaked at 30 seconds and increased Pyk2/c-Src binding 90 seconds. isolated by immunoprecipitation studied cell-free system was activated phosphorylated acidic pH. Acid activation (a) specific for did not activate focal adhesion kinase, (b) required calcium, (c)...
Biomimetic oxidative dimerization of tryptophan derivatives in aqueous media with oxygen as a bulk oxidant catalyzed by an iron octacarboxy phthalocyanine complex was established. The discovery the extremely active catalyst enables aerobic enzyme-mimetic oxidation to be performed flask. This method applicable wide range derivatives, including various dipeptides and oligopeptides, remarkable functional-group tolerance without protection amino acid residues. Furthermore, bearing...
C57BL/6 (B6) mice were i.v. presensitized with class I H-2-disparate B6-C-H-2bm1 (bm1) spleen cells. Such presensitization resulted in almost complete abrogation of bm1-specific Lyt-2+ T cell-mediated proliferative and IL-2-producing capacities as measured by MLC lymphoid cells from B6 stimulating bm1 In contrast, comparable magnitude CTL responses was generated bulk cultures to that obtained unpresensitized responding cultures. These differential influences cell functions also demonstrated...
Previous clinical studies have shown that heat-killed Lacticaseibacillus paracasei MCC1849 suppresses subjective symptoms among healthy adults. However, the mechanism underlying this beneficial effect remains unclear. This study aimed to investigate effects of on immune functions in humans. In randomized, double-blind, placebo-controlled, parallel-group study, 100 adults were randomly divided into or placebo groups. Participants ingested test powder with 5 × 1010 cells for 4 weeks. Immune...
This study examines pathways to psychiatric care in Japan using the same method as collaborative carried out 1991 under auspices of World Health Organization.Thirteen facilities were involved. Of 228 patients who contacted with any illness, eighty four visiting for first time enrolled. Pathways care, delays from onset illness treatment prior reaching psychiatrists surveyed.Thirty three (39.4%) directly accessed mental health professionals, 32 (38.1%) reached them via general hospital, and 13...
Human immunodeficiency virus type-1 (HIV-1) protease is essential for viral propagation, and its inhibitors are key anti-HIV-1 drug candidates. In this study, we discovered a novel HIV-1 inhibitor (compound 16) with potent antiviral activity oral bioavailability using structure-based design approach via X-ray crystal structure analysis improved metabolic stability, starting from hit macrocyclic peptides identified by mRNA display against protease. We found that the improvement of proteolytic...
Abstract The function of the Fc receptors γ chain (FcR ) for expression T cell receptor (TCR) complex and development, especially cells localized in epithelia, was investigated by analyzing FcR ‐deficient mice. In wildtype mice, CD8αα + β − TCRαβ intestinal intraepithelial lymphocytes (i‐IEL) utilized CD3ζ homodimers ζ‐FcR heterodimers, whereas CD8α α TCR δ i‐IEL used complex. On other hand, these mice contained only ζ homodimers. surface reduced dendritic epidermal (DETC) development...
We previously described new antiinflammatory agents, 4-hydroxy-2-oxo-1-phenyl-1H-1,8-naphthyridine-3-carboxamides 1. Further modification of the compounds bearing 1-phenyl-1,8-naphthyridin-2-one as a mother skeleton led to 5-phenylimidazo[4,5-c][1,8]naphthyridin-4(5H)-one derivatives 2 and 3. Regioselective synthesis these substituent at 1- or 3-position was conducted according method shown in Schemes I II. In this series compounds, activities were greatly influenced by position nature...
We previously reported that the intake of heat-killed Lacticaseibacillus paracasei MCC1849 suppressed onset cold-like symptoms in healthy young women who were susceptible to colds. This study aimed investigate effects on subjective physical condition adults a wide age range. In this randomized, double-blind, placebo-controlled, parallel-group study, 200 randomly divided into group or placebo group. The participants received test powder with 50 billion cells without for 24 weeks. Subjective...
A protocol for the allylation at C3a-position of hexahydropyrroloindole using allylsilanes is developed. AgNTf2 proved to be an efficient activator halopyrroloindoline substrates. This method applicable introduction various allyl groups including reverse prenyl group. The utility this reaction demonstrated by total synthesis amauromine alkaloids. Stepwise bromocyclizations bis-indolylmethyl diketopiperazine derivative and subsequent double prenylation furnished (+)-novoamauromine (-)-epiamauromine.
The effects of (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz [b.e.]oxepin-2-acetic acid monohydrochloride (KW-4679), an orally active antiallergic drug, on the production platelet-activating factor (PAF), leukotriene (LT) and thromboxane (TX) induced by Ca2+ ionophore A23187 were examined. KW-4679 at 10 microM reduced amount cell-associated PAF 52.8% in human polymorphonuclear leukocytes (PMNs). (1-100 microM) also inhibited release both LTB4 TXB2, a stable metabolite TXA2, PMNs...
Abstract The present study investigates the effects of i.v. presensitization with class II H-2-disparate allogeneic cells on various L3T4+ T cell functions including capability rejecting corresponding skin graft. C57BL/6 (B6) mice were presensitized H-2 disparate B6-C-H-2bm12 (bm12) spleen cells. Such did not affect bm12-specific cell-mediated proliferative and interleukin 2 (IL-2)-producing capacities. A single suspension (B6 x bm12)F1 was depleted APC by two round-passages over Sephadex...